Assessment of Structural Intolerance and Durability
General Structure Information 2ew3 SH3GL3 solution structure of the sh3 domain of human sh3gl3 -1.0Å AUTH Y.G.GAO,X.Z.YAN,H.Y.HUTITL STRUCTURAL BASIS FOR THE BINDING SPECIFICITIES OFTITL 2 HUNTINGTIN PROLINE-RICH REGION WITH SH3 AND WWTITL 3 DOMAINSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4apc NEK1 crystal structure of human nima-related kinase 1 (nek1) 2.1Å AUTH J.M.ELKINS,T.D.M.HANCHUK,D.V.LOVATO,F.L.BASEI,G.V.MEIRELLES,AUTH 2 J.KOBARG,M.SZKLARZ,M.VOLLMAR,P.MAHAJAN,P.RELLOS,Y.ZHANG,AUTH 3 T.KROJER,A.C.W.PIKE,C.BOUNTRA,C.ARROWSMITH,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN NIMA-RELATED KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2b6f SRXN1 solution structure of human sulfiredoxin (srx) -1.0Å AUTH D.-Y.LEE,S.J.PARK,W.JEONG,H.J.SUNG,T.OHO,X.WU,AUTH 2 S.G.RHEE,J.M.GRUSCHUSTITL MUTAGENESIS AND MODELING OF THE PEROXIREDOXINTITL 2 (PRX) COMPLEX WITH THE NMR STRUCTURE OF ATP-BOUNDTITL 3 HUMAN SULFIREDOXIN IMPLICATE ASPARTATE 187 OF PRXTITL 4 I AS THE CATALYTIC RESIDUE IN ATP HYDROLYSISREF BIOCHEMISTRY V. 45 15301 2006REFN ISSN 0006-2960PMID […]
General Structure Information 1uw4 UPF3B the structural basis of the interaction between nonsense mediated decay factors upf2 and upf3 1.95Å AUTH J.KADLEC,E.IZAURRALDE,S.CUSACKTITL THE STRUCTURAL BASIS FOR THE INTERACTION BETWEENTITL 2 NONSENSE-MEDIATED MRNA DECAY FACTORS UPF2 AND UPF3REF NAT.STRUCT.MOL.BIOL. V. 11 330 2004REFN ISSN 1545-9993PMID 15004547DOI 10.1038/NSMB741 Variant Set Distributions Mapped Variants
General Structure Information 4gl2 IFIH1 structural basis for dsrna duplex backbone recognition by mda5 3.56Å AUTH B.WU,A.PEISLEY,C.RICHARDS,H.YAO,X.ZENG,C.LIN,F.CHU,T.WALZ,AUTH 2 S.HURTITL STRUCTURAL BASIS FOR DSRNA RECOGNITION, FILAMENT FORMATION,TITL 2 AND ANTIVIRAL SIGNAL ACTIVATION BY MDA5.REF CELL(CAMBRIDGE,MASS.) V. 152 276 2013REFN ISSN 0092-8674PMID 23273991DOI 10.1016/J.CELL.2012.11.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3rqf PDCD10 cerebral cavernous malformation 3 (ccm3) in complex with paxillin ld2 2.7Å AUTH X.LI,W.JI,R.ZHANG,E.FOLTA-STOGNIEW,W.MIN,T.J.BOGGONTITL MOLECULAR RECOGNITION OF LEUCINE-ASPARTATE REPEAT (LD)TITL 2 MOTIFS BY THE FOCAL ADHESION TARGETING HOMOLOGY DOMAIN OFTITL 3 CEREBRAL CAVERNOUS MALFORMATION 3 (CCM3).REF J.BIOL.CHEM. V. 286 26138 2011REFN ISSN 0021-9258PMID 21632544DOI 10.1074/JBC.M110.211250 Variant Set Distributions Mapped Variants
General Structure Information 4h4f CTRC crystal structure of human chymotrypsin c (ctrc) bound to inhibitor eglin c from hirudo medicinalis 1.9Å AUTH J.BATRA,A.SZABO,T.R.CAULFIELD,A.S.SOARES,M.SAHIN-TOTH,AUTH 2 E.S.RADISKYTITL LONG-RANGE ELECTROSTATIC COMPLEMENTARITY GOVERNS SUBSTRATETITL 2 RECOGNITION BY HUMAN CHYMOTRYPSIN C, A KEY REGULATOR OFTITL 3 DIGESTIVE ENZYME ACTIVATION.REF J.BIOL.CHEM. V. 288 9848 2013REFN ISSN 0021-9258PMID 23430245DOI 10.1074/JBC.M113.457382 Variant Set […]
General Structure Information 2lnb ZBP1 solution nmr structure of n-terminal domain (6-74) of human zbp1 protein, northeast structural genomics consortium target hr8174a. -1.0Å AUTH Y.YANG,T.A.RAMELOT,K.HAMILTON,E.KOHAN,D.WANG,T.B.ACTON,AUTH 2 R.XIAO,J.K.EVERETT,G.T.MONTELIONE,M.A.KENNEDYTITL SOLUTION NMR STRUCTURE OF N-TERMINAL DOMAIN (6-74) OF HUMANTITL 2 ZBP1 PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUMTITL 3 TARGET HR8174AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fqn CCM2 crystal structure of the ccm2 c-terminal harmonin homology domain (hhd) 1.9Å AUTH O.S.FISHER,R.ZHANG,X.LI,J.W.MURPHY,B.DEMELER,T.J.BOGGONTITL STRUCTURAL STUDIES OF CEREBRAL CAVERNOUS MALFORMATIONS 2TITL 2 (CCM2) REVEAL A FOLDED HELICAL DOMAIN AT ITS C-TERMINUS.REF FEBS LETT. V. 587 272 2013REFN ISSN 0014-5793PMID 23266514DOI 10.1016/J.FEBSLET.2012.12.011 Variant Set Distributions Mapped Variants
General Structure Information 2ra4 CCL13 crystal structure of human monocyte chemoattractant protein 4 (mcp- 4/ccl13) 1.7Å AUTH C.BARINKA,A.PRAHL,J.LUBKOWSKITITL STRUCTURE OF HUMAN MONOCYTE CHEMOATTRACTANT PROTEIN 4TITL 2 (MCP-4/CCL13).REF ACTA CRYSTALLOGR.,SECT.D V. 64 273 2008REFN ISSN 0907-4449PMID 18323622DOI 10.1107/S0907444907066164 Variant Set Distributions Mapped Variants