Assessment of Structural Intolerance and Durability
General Structure Information 3h11 CFLAR zymogen caspase-8:c-flipl protease domain complex 1.9Å AUTH J.W.YU,P.D.JEFFREY,Y.SHITITL MECHANISM OF PROCASPASE-8 ACTIVATION BY C-FLIPL.REF PROC.NATL.ACAD.SCI.USA V. 106 8169 2009REFN ISSN 0027-8424PMID 19416807DOI 10.1073/PNAS.0812453106 Variant Set Distributions Mapped Variants
General Structure Information 4a9c INPPL1 crystal structure of human ship2 in complex with biphenyl 2,3,4,5,6-pentakisphosphate 2.1Å AUTH S.J.MILLS,C.PERSSON,G.COZIER,M.P.THOMAS,L.TRESAUGUES,AUTH 2 C.ERNEUX,A.M.RILEY,P.NORDLUND,B.V.L.POTTERTITL A SYNTHETIC POLYPHOSPHOINOSITIDE HEADGROUP SURROGATE INTITL 2 COMPLEX WITH SHIP2 PROVIDES A RATIONALE FOR DRUG DISCOVERY.REF ACS CHEM.BIOL. V. 7 822 2012REFN ISSN 1554-8929PMID 22330088DOI 10.1021/CB200494D Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2dis RBM47 solution structure of the rrm domain of unnamed protein product -1.0Å AUTH W.DANG,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RRM DOMAIN OF UNNAMEDTITL 2 PROTEIN PRODUCTREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2amy PMM2 x-ray structure of human phosphomannomutase 2 (pmm2) 2.09Å AUTH CENTER FOR EUKARYOTIC STRUCTURAL GENOMICS (CESG)TITL X-RAY STRUCTURE OF HUMAN PHOSPHOMANNOMUTASE 2 (PMM2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2zg2 SIGLEC5 crystal structure of two n-terminal domains of native siglec-5 2.85Å AUTH M.A.ZHURAVLEVA,K.TRANDEM,P.D.SUNTITL STRUCTURAL IMPLICATIONS OF SIGLEC-5-MEDIATEDTITL 2 SIALOGLYCAN RECOGNITIONREF J.MOL.BIOL. V. 375 437 2008REFN ISSN 0022-2836PMID 18022638DOI 10.1016/J.JMB.2007.10.009 Variant Set Distributions Mapped Variants
General Structure Information 3gkh NPC1 npc1(ntd) 1.81Å AUTH H.J.KWON,L.ABI-MOSLEH,M.L.WANG,J.DEISENHOFER,J.L.GOLDSTEIN,AUTH 2 M.S.BROWN,R.E.INFANTETITL STRUCTURE OF N-TERMINAL DOMAIN OF NPC1 REVEALS DISTINCTTITL 2 SUBDOMAINS FOR BINDING AND TRANSFER OF CHOLESTEROL.REF CELL(CAMBRIDGE,MASS.) V. 137 1213 2009REFN ISSN 0092-8674PMID 19563754DOI 10.1016/J.CELL.2009.03.049 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b6v KIF3C crystal structure of the motor domain of human kinesin family member 3c in complex with adp 2.7Å AUTH H.ZHU,W.TEMPEL,Y.SHEN,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER 3C IN COMPLEXTITL 2 WITH ADP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2wfq DHH crystal structure of the n-terminal signalling domain of human dhh without calcium 1.85Å AUTH B.BISHOP,A.R.ARICESCU,K.HARLOS,C.A.OCALLAGHAN,E.Y.JONES,AUTH 2 C.SIEBOLDTITL STRUCTURAL INSIGHTS INTO HEDGEHOG LIGAND SEQUESTRATION BYTITL 2 THE HUMAN HEDGEHOG-INTERACTING PROTEIN HIPREF NAT.STRUCT.MOL.BIOL. V. 16 698 2009REFN ISSN 1545-9993PMID 19561611DOI 10.1038/NSMB.1607 Variant Set Distributions Mapped Variants
General Structure Information 2ep8 PES1 solution structure of the brct domain from human pescadillo homolog 1 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BRCT DOMAIN FROM HUMANTITL 2 PESCADILLO HOMOLOG 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1gh2 TXNL1 crystal structure of the catalytic domain of a new human thioredoxin-like protein 2.22Å AUTH J.JIN,X.CHEN,Y.ZHOU,M.BARTLAM,Q.GUO,Y.LIU,Y.SUN,AUTH 2 Y.GAO,S.YE,G.LI,Z.RAO,B.QIANG,J.YUANTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF ATITL 2 HUMAN THIOREDOXIN-LIKE PROTEIN.REF EUR.J.BIOCHEM. V. 269 2060 2002REFN ISSN 0014-2956PMID 11985582DOI 10.1046/J.1432-1033.2002.02844.X Variant Set Distributions Mapped Variants