Assessment of Structural Intolerance and Durability
General Structure Information 1yck PGLYRP1 crystal structure of human peptidoglycan recognition protein (pgrp-s) 1.7Å AUTH R.GUAN,Q.WANG,E.J.SUNDBERG,R.A.MARIUZZATITL CRYSTAL STRUCTURE OF HUMAN PEPTIDOGLYCANTITL 2 RECOGNITION PROTEIN S (PGRP-S) AT 1.70 ATITL 3 RESOLUTION.REF J.MOL.BIOL. V. 347 683 2005REFN ISSN 0022-2836PMID 15769462DOI 10.1016/J.JMB.2005.01.070 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t5i PDE6D structure of fully modified farnesylated rheb peptide in complex with pde6d 2.1Å AUTH S.A.ISMAIL,Y.X.CHEN,A.RUSINOVA,A.CHANDRA,M.BIERBAUM,AUTH 2 L.GREMER,G.TRIOLA,H.WALDMANN,P.I.BASTIAENS,A.WITTINGHOFERTITL ARL2-GTP AND ARL3-GTP REGULATE A GDI-LIKE TRANSPORT SYSTEMTITL 2 FOR FARNESYLATED CARGO.REF NAT.CHEM.BIOL. V. 7 942 2011REFN ISSN 1552-4450PMID 22002721DOI 10.1038/NCHEMBIO.686 Variant Set Distributions Mapped Variants
General Structure Information 4dlo BAI3 crystal structure of the gain and hormr domains of brain angiogenesis inhibitor 3 (bai3) 2.3Å AUTH D.ARAC,A.A.BOUCARD,M.F.BOLLIGER,J.NGUYEN,S.M.SOLTIS,AUTH 2 T.C.SUDHOF,A.T.BRUNGERTITL A NOVEL EVOLUTIONARILY CONSERVED DOMAIN OF CELL-ADHESIONTITL 2 GPCRS MEDIATES AUTOPROTEOLYSIS.REF EMBO J. V. 31 1364 2012REFN ISSN 0261-4189PMID 22333914DOI 10.1038/EMBOJ.2012.26 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2lsp BRD4 solution structures of brd4 second bromodomain with nf-kb-k310ac peptide -1.0Å AUTH G.ZHANG,R.LIU,Y.ZHONG,A.N.PLOTNIKOV,W.ZHANG,L.ZENG,AUTH 2 E.RUSINOVA,G.GERONA-NEVARRO,N.MOSHKINA,J.JOSHUA,P.Y.CHUANG,AUTH 3 M.OHLMEYER,J.C.HE,M.M.ZHOUTITL DOWN-REGULATION OF NF-KAPPA B TRANSCRIPTIONAL ACTIVITY INTITL 2 HIV-ASSOCIATED KIDNEY DISEASE BY BRD4 INHIBITION.REF J.BIOL.CHEM. V. 287 28840 2012REFN ISSN 0021-9258PMID 22645123DOI 10.1074/JBC.M112.359505 Variant Set Distributions Mapped Variants
General Structure Information 4mbb DUSP11 cubic crystal form of pir1 dual specificity phosphatase core 1.85Å AUTH R.S.SANKHALA,R.K.LOKAREDDY,G.CINGOLANITITL STRUCTURE OF HUMAN PIR1, AN ATYPICAL DUAL-SPECIFICITYTITL 2 PHOSPHATASE.REF BIOCHEMISTRY V. 53 862 2014REFN ISSN 0006-2960PMID 24447265DOI 10.1021/BI401240X Variant Set Distributions Mapped Variants
General Structure Information 3l50 GMFG the crystal structure of human glia maturation factor, gamma (gmfg) 1.9Å AUTH E.UGOCHUKWU,E.PILKA,E.KRYSZTOFINSKA,E.HAPKA,T.KROJER,AUTH 2 J.MUNIZ,M.VOLLMAR,A.C.W.PIKE,F.VON DELFT,K.L.KAVANAGH,AUTH 3 U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN GLIA MATURATION FACTOR, GAMMATITL 2 (GMFG)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ihb DYSF x-ray structure of the canonical c2a domain from human dysferlin 2.04Å AUTH K.FUSON,A.RICE,R.MAHLING,A.SNOW,K.NAYAK,P.SHANBHOGUE,AUTH 2 A.G.MEYER,G.M.REDPATH,A.HINDERLITER,S.T.COOPER,R.B.SUTTONTITL ALTERNATE SPLICING OF DYSFERLIN C2A CONFERS CA(2+)-DEPENDENTTITL 2 AND CA(2+)-INDEPENDENT BINDING FOR MEMBRANE REPAIR.REF STRUCTURE V. 22 104 2014REFN ISSN 0969-2126PMID 24239457DOI 10.1016/J.STR.2013.10.001 Variant Set Distributions Mapped Variants
General Structure Information 2e9j FLNB solution structure of the 14th filamin domain from human filamin-b -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 14TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN-BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2fyt PRMT3 human hmt1 hnrnp methyltransferase-like 3 (s. cerevisiae) protein 2.0Å AUTH H.WU,J.R.MIN,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNPTITL 2 METHYLTRANSFERASE-LIKE 3 IN COMPLEX WITH SAH.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1t0l IDH1 crystal structure of human cytosolic nadp(+)-dependent isocitrate dehydrogenase in complex with nadp, isocitrate, and calcium(2+) 2.41Å AUTH X.XU,J.ZHAO,Z.XU,B.PENG,Q.HUANG,E.ARNOLD,J.DINGTITL STRUCTURES OF HUMAN CYTOSOLIC NADP-DEPENDENTTITL 2 ISOCITRATE DEHYDROGENASE REVEAL A NOVELTITL 3 SELF-REGULATORY MECHANISM OF ACTIVITYREF J.BIOL.CHEM. V. 279 33946 2004REFN ISSN 0021-9258PMID 15173171DOI 10.1074/JBC.M404298200 Variant Set Distributions Ripley’s K Analysis Plots […]