Assessment of Structural Intolerance and Durability
General Structure Information 2crw ARFGAP3 solution structure of the arfgap domain of adp-ribosylation factor gtpaseactivating protein 3 (arfgap 3) -1.0Å AUTH H.P.ZHANG,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ARFGAP DOMAIN OFTITL 2 ADP-RIBOSYLATION FACTOR GTPASEACTIVATING PROTEIN 3TITL 3 (ARFGAP 3)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2iwz OXSM human mitochondrial beta-ketoacyl acp synthase complexed with hexanoic acid 1.65Å AUTH C.E.CHRISTENSEN,B.B.KRAGELUND,P.VON WETTSTEIN-KNOWLES,AUTH 2 A.HENRIKSENTITL STRUCTURE OF THE HUMAN BETA-KETOACYL [ACP] SYNTHASE FROMTITL 2 THE MITOCHONDRIAL TYPE II FATTY ACID SYNTHASE.REF PROTEIN SCI. V. 16 261 2007REFN ISSN 0961-8368PMID 17242430DOI 10.1110/PS.062473707 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4mpm NGB wild-type human neuroglobin 1.74Å AUTH B.G.GUIMARAES,D.HAMDANE,C.LECHAUVE,M.C.MARDEN,AUTH 2 B.GOLINELLI-PIMPANEAUTITL THE CRYSTAL STRUCTURE OF WILD-TYPE HUMAN BRAIN NEUROGLOBINTITL 2 REVEALS FLEXIBILITY OF THE DISULFIDE BOND THAT REGULATESTITL 3 OXYGEN AFFINITY.REF ACTA CRYSTALLOGR.,SECT.D V. 70 1005 2014REFN ISSN 0907-4449PMID 24699645DOI 10.1107/S1399004714000078 Variant Set Distributions Mapped Variants
General Structure Information 4ks7 PAK6 pak6 kinase domain in complex with pf-3758309 1.4Å AUTH J.GAO,B.H.HA,H.J.LOU,E.M.MORSE,R.ZHANG,D.A.CALDERWOOD,AUTH 2 B.E.TURK,T.J.BOGGONTITL SUBSTRATE AND INHIBITOR SPECIFICITY OF THE TYPE IITITL 2 P21-ACTIVATED KINASE, PAK6.REF PLOS ONE V. 8 77818 2013REFN ESSN 1932-6203PMID 24204982DOI 10.1371/JOURNAL.PONE.0077818 Variant Set Distributions Mapped Variants
General Structure Information 3pb9 QPCTL crystal structure of the catalytic domain of human golgi-resident glutaminyl cyclase in complex with 1-benzylimidazole 1.12Å AUTH K.F.HUANG,S.S.LIAW,W.L.HUANG,C.Y.CHIA,Y.C.LO,Y.L.CHEN,AUTH 2 A.H.J.WANGTITL STRUCTURES OF HUMAN GOLGI-RESIDENT GLUTAMINYL CYCLASE ANDTITL 2 ITS COMPLEXES WITH INHIBITORS REVEAL A LARGE LOOP MOVEMENTTITL 3 UPON INHIBITOR BINDINGREF J.BIOL.CHEM. V. 286 12439 2011REFN ISSN 0021-9258PMID 21288892DOI 10.1074/JBC.M110.208595 […]
General Structure Information 2jfl SLK crystal structure of human ste20-like kinase ( diphosphorylated form) bound to 5- amino-3-((4-( aminosulfonyl)phenyl)amino)-n-(2,6- difluorophenyl)-1h-1,2, 4-triazole-1-carbothioamide 2.2Å AUTH A.C.W.PIKE,P.RELLOS,F.H.NIESEN,A.TURNBULL,A.W.OLIVER,AUTH 2 S.A.PARKER,B.E.TURK,L.H.PEARL,S.KNAPPTITL ACTIVATION SEGMENT DIMERIZATION: A MECHANISM FOR KINASETITL 2 AUTOPHOSPHORYLATION OF NON-CONSENSUS SITES.REF EMBO J. V. 27 704 2008REFN ISSN 0261-4189PMID 18239682DOI 10.1038/EMBOJ.2008.8 Variant Set Distributions Mapped Variants
General Structure Information 3dzx TBC1D22B crystal structure of the rabgap domain of human tbc1d22b 2.3Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,Y.SHEN,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF HUMAN TBC1D22BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ilr FANCE crystal structure of human fanconi anemia protein e c- terminal domain 2.0Å AUTH R.K.NOOKALA,S.HUSSAIN,L.PELLEGRINITITL INSIGHTS INTO FANCONI ANAEMIA FROM THE STRUCTURETITL 2 OF HUMAN FANCEREF NUCLEIC ACIDS RES. V. 35 1638 2007REFN ISSN 0305-1048PMID 17308347DOI 10.1093/NAR/GKM033 Variant Set Distributions Mapped Variants
General Structure Information 4jqf OBFC1 structure of the c-terminal domain of human telomeric stn1 1.6Å AUTH C.BRYAN,C.RICE,M.HARKISHEIMER,D.C.SCHULTZ,E.SKORDALAKESTITL STRUCTURE OF THE HUMAN TELOMERIC STN1-TEN1 CAPPING COMPLEX.REF PLOS ONE V. 8 66756 2013REFN ESSN 1932-6203PMID 23826127DOI 10.1371/JOURNAL.PONE.0066756 Variant Set Distributions Mapped Variants
General Structure Information 2dlv RGS18 solution structure of the rgs domain of human regulator of g-protein signaling 18 -1.0Å AUTH H.P.ZHANG,T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RGS DOMAIN OF HUMANTITL 2 REGULATOR OF G-PROTEIN SIGNALING 18REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants