Assessment of Structural Intolerance and Durability
General Structure Information 2yvq CPS1 crystal structure of mgs domain of carbamoyl-phosphate synthetase from homo sapiens 1.98Å AUTH Y.XIE,IHSANAWATI,S.KISHISHITA,K.MURAYAMA,AUTH 2 C.TAKEMOTO,M.SHIROZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF MGS DOMAIN OFTITL 2 CARBAMOYL-PHOSPHATE SYNTHETASE FROM HOMO SAPIENSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3fxm PPM1A crystal structure of human protein phosphatase 1a (ppm1a) bound with citrate at 10 mm of mn2+ 2.5Å AUTH T.HU,L.WANG,K.WANG,J.CHEN,H.JIANG,X.SHENTITL STRUCTURAL BASIS FOR THE MN2+-DEPENDENT ACTIVATIONTITL 2 OF HUMAN PPM1AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2dks CEACAM8 solution structure of the first ig-like domain of human carcinoembryonic antigen related cell adhesion molecule 8 -1.0Å AUTH K.NAGASHIMA,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST IG-LIKE DOMAIN OFTITL 2 HUMAN CARCINOEMBRYONIC ANTIGEN RELATED CELLTITL 3 ADHESION MOLECULE 8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1s9i MAP2K2 x-ray structure of the human mitogen-activated protein kinase kinase 2 (mek2)in a complex with ligand and mgatp 3.2Å AUTH J.F.OHREN,H.CHEN,A.PAVLOVSKY,C.WHITEHEAD,E.ZHANG,AUTH 2 P.KUFFA,C.YAN,P.MCCONNELL,C.SPESSARD,C.BANOTAI,AUTH 3 W.T.MUELLER,A.DELANEY,C.OMER,J.SEBOLT-LEOPOLD,AUTH 4 D.T.DUDLEY,I.K.LEUNG,C.FLAMME,J.WARMUS,M.KAUFMAN,AUTH 5 S.BARRETT,H.TECLE,C.A.HASEMANNTITL STRUCTURES OF HUMAN MAP KINASE KINASE 1 (MEK1) ANDTITL 2 MEK2 DESCRIBE NOVEL NONCOMPETITIVE KINASETITL 3 INHIBITION.REF NAT.STRUCT.MOL.BIOL. V. 11 1192 2004REFN […]
General Structure Information 1ncn CD86 the receptor-binding domain of human b7-2 2.7Å AUTH X.ZHANG,J.D.SCHWARTZ,S.C.ALMO,S.G.NATHENSONTITL CRYSTAL STRUCTURE OF THE RECEPTOR-BINDING DOMAINTITL 2 OF HUMAN B7-2: INSIGHTS INTO ORGANIZATION ANDTITL 3 SIGNALINGREF PROC.NATL.ACAD.SCI.USA V. 100 2586 2003REFN ISSN 0027-8424PMID 12606712DOI 10.1073/PNAS.252771499 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4imn PTGDS crystal structure of wild type human lipocalin pgds bound with peg mme 2000 2.09Å AUTH S.M.LIM,D.CHEN,H.TEO,A.ROOS,A.E.JANSSON,T.NYMAN,AUTH 2 L.TRESAUGUES,K.PERVUSHIN,P.NORDLUNDTITL STRUCTURAL AND DYNAMIC INSIGHTS INTO SUBSTRATE BINDING ANDTITL 2 CATALYSIS OF HUMAN LIPOCALIN PROSTAGLANDIN D SYNTHASE.REF J.LIPID RES. V. 54 1630 2013REFN ISSN 0022-2275PMID 23526831DOI 10.1194/JLR.M035410 Variant Set Distributions Mapped Variants
General Structure Information 1plo TGFBR2 transforming growth factor-beta type ii receptor extracellular domain -1.0Å AUTH S.DEEP,K.P.WALKER III,Z.SHU,A.P.HINCKTITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THETITL 2 TGF-BETA TYPE II RECEPTOR EXTRACELLULAR DOMAINREF BIOCHEMISTRY V. 42 10126 2003REFN ISSN 0006-2960PMID 12939140DOI 10.1021/BI034366A Variant Set Distributions Mapped Variants
General Structure Information 3ihp USP5 covalent ubiquitin-usp5 complex 2.8Å AUTH J.R.WALKER,G.V.AVVAKUMOV,S.XUE,C.BUTLER-COLE,AUTH 2 J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANONTITL COVALENT UBIQUITIN-USP5 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1emo FBN1 nmr study of a pair of fibrillin ca2+ binding epidermal growth factor-like domains, 22 structures -1.0Å AUTH A.K.DOWNING,V.KNOTT,J.M.WERNER,C.M.CARDY,AUTH 2 I.D.CAMPBELL,P.A.HANDFORDTITL SOLUTION STRUCTURE OF A PAIR OF CALCIUM-BINDINGTITL 2 EPIDERMAL GROWTH FACTOR-LIKE DOMAINS: IMPLICATIONSTITL 3 FOR THE MARFAN SYNDROME AND OTHER GENETICTITL 4 DISORDERS.REF CELL(CAMBRIDGE,MASS.) V. 85 597 1996REFN ISSN 0092-8674PMID […]
General Structure Information 3n2z PRCP the structure of human prolylcarboxypeptidase at 2.80 angstroms resolution 2.79Å AUTH S.M.SOISSON,S.B.PATEL,P.D.ABEYWICKREMA,N.J.BRYNE,R.E.DIEHL,AUTH 2 D.L.HALL,R.E.FORD,J.C.REID,K.W.RICKERT,J.M.SHIPMAN,S.SHARMA,AUTH 3 K.J.LUMBTITL STRUCTURAL DEFINITION AND SUBSTRATE SPECIFICITY OF THE S28TITL 2 PROTEASE FAMILY: THE CRYSTAL STRUCTURE OF HUMANTITL 3 PROLYLCARBOXYPEPTIDASE.REF BMC STRUCT.BIOL. V. 10 16 2010REFN ESSN 1472-6807PMID 20540760DOI 10.1186/1472-6807-10-16 Variant Set Distributions Ripley’s K Analysis […]