General Structure Information 4fu4 MMP13 human collagenase 3 (mmp-13) with peptide from pro-domain 2.85Å AUTH E.A.STURA,R.VISSE,P.CUNIASSE,V.DIVE,H.NAGASETITL CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN COLLAGENASE 3TITL 2 (MMP-13) WITH PEPTIDES IN THE ACTIVE SITE DEFINES EXOSITESTITL 3 IN THE CATALYTIC DOMAIN.REF FASEB J. V. 27 4395 2013REFN ISSN 0892-6638PMID 23913860DOI 10.1096/FJ.13-233601 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3uom CASQ1 ca2+ complex of human skeletal calsequestrin 2.02Å AUTH E.J.SANCHEZ,K.M.LEWIS,B.R.DANNA,C.KANGTITL HIGH-CAPACITY CA2+ BINDING OF HUMAN SKELETAL CALSEQUESTRIN.REF J.BIOL.CHEM. V. 287 11592 2012REFN ISSN 0021-9258PMID 22337878DOI 10.1074/JBC.M111.335075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3evs GDF5 crystal structure of the gdf-5:bmp receptor ib complex. 2.1Å AUTH A.KOTZSCH,J.NICKEL,A.SEHER,W.SEBALD,T.D.MULLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS A SPRING-LOADED LATCH ASTITL 2 MOLECULAR MECHANISM FOR GDF-5-TYPE I RECEPTOR SPECIFICITY.REF EMBO J. V. 28 937 2009REFN ISSN 0261-4189PMID 19229295DOI 10.1038/EMBOJ.2009.37 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3alo MAP2K4 crystal structure of human non-phosphorylated mkk4 kinase domain ternary complex with amp-pnp and p38 peptide 2.6Å AUTH T.MATSUMOTO,T.KINOSHITA,Y.KIRII,K.YOKOTA,K.HAMADA,T.TADATITL CRYSTAL STRUCTURES OF MKK4 KINASE DOMAIN REVEAL THATTITL 2 SUBSTRATE PEPTIDE BINDS TO AN ALLOSTERIC SITE AND INDUCES ANTITL 3 AUTO-INHIBITION STATEREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 400 369 2010REFN ISSN 0006-291XPMID 20732303DOI 10.1016/J.BBRC.2010.08.071 Variant […]
General Structure Information 2pqa RPA3 crystal structure of full-length human rpa 14/32 heterodimer 2.5Å AUTH X.DENG,J.E.HABEL,V.KABALEESWARAN,E.H.SNELL,M.S.WOLD,AUTH 2 G.E.BORGSTAHLTITL STRUCTURE OF THE FULL-LENGTH HUMAN RPA14/32 COMPLEX GIVESTITL 2 INSIGHTS INTO THE MECHANISM OF DNA BINDING AND COMPLEXTITL 3 FORMATION.REF J.MOL.BIOL. V. 374 865 2007REFN ISSN 0022-2836PMID 17976647DOI 10.1016/J.JMB.2007.09.074 Variant Set Distributions Mapped Variants
General Structure Information 3rpg BMI1 bmi1/ring1b-ubch5c complex structure 2.65Å AUTH M.L.BENTLEY,J.E.CORN,K.C.DONG,Q.PHUNG,T.K.CHEUNG,A.G.COCHRANTITL RECOGNITION OF UBCH5C AND THE NUCLEOSOME BY THE BMI1/RING1BTITL 2 UBIQUITIN LIGASE COMPLEX.REF EMBO J. V. 30 3285 2011REFN ISSN 0261-4189PMID 21772249DOI 10.1038/EMBOJ.2011.243 Variant Set Distributions Mapped Variants
General Structure Information 4cga CHKA human choline kinase a1 in complex with compound 5 1.74Å AUTH B.RUBIO-RUIZ,A.FIGUEROLA-CONCHAS,J.RAMOS-TORRECILLAS,AUTH 2 F.CAPITAN-CANADAS,P.RIOS-MARCO,M.P.CARRASCO,M.A.GALLO,AUTH 3 A.ESPINOSA,C.MARCO,C.CONCEPCION,A.ENTRENA-GUADIX,AUTH 4 R.HURTADO-GUERRERO,A.CONEJO-GARCIATITL DISCOVERY OF A NEW BINDING SITE ON HUMAN CHOLINE KINASE A1:TITL 2 DESIGN, SYNTHESIS, CRYSTALLOGRAPHIC STUDIES AND BIOLOGICALTITL 3 EVALUATION OF ASYMMETRICAL BISPYRIDINIUM DERIVATIVESREF J.MED.CHEM. V. 57 507 2014REFN ISSN 0022-2623PMID 24387243DOI […]
General Structure Information 1i27 GTF2F1 crystal structure of the c-terminal domain of the rap74 subunit of human transcription factor iif (tfiif) 1.02Å AUTH K.KAMADA,J.DE ANGELIS,R.G.ROEDER,S.K.BURLEYTITL CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THETITL 2 RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF.REF PROC.NATL.ACAD.SCI.USA V. 98 3115 2001REFN ISSN 0027-8424PMID 11248041DOI 10.1073/PNAS.051631098 Variant Set Distributions Mapped Variants
General Structure Information 1j1d TNNT2 crystal structure of the 46kda domain of human cardiac troponin in the ca2+ saturated form 2.61Å AUTH S.TAKEDA,A.YAMASHITA,K.MAEDA,Y.MAEDATITL STRUCTURE OF THE CORE DOMAIN OF HUMAN CARDIACTITL 2 TROPONIN IN THE CA2+-SATURATED FORMREF NATURE V. 424 35 2003REFN ISSN 0028-0836PMID 12840750DOI 10.1038/NATURE01780 Variant Set Distributions Mapped Variants
General Structure Information 2m74 FBN1 1h, 13c and 15n assignments of the four n-terminal domains of human fibrillin-1 -1.0Å AUTH D.A.YADIN,I.B.ROBERTSON,J.MCNAUGHT-DAVIS,P.EVANS,D.STODDART,AUTH 2 P.A.HANDFORD,S.A.JENSEN,C.REDFIELDTITL STRUCTURE OF THE FIBRILLIN-1 N-TERMINAL DOMAINS SUGGESTSTITL 2 THAT HEPARAN SULFATE REGULATES THE EARLY STAGES OFTITL 3 MICROFIBRIL ASSEMBLY.REF STRUCTURE V. 21 1743 2013REFN ISSN 0969-2126PMID 24035709DOI 10.1016/J.STR.2013.08.004 Variant Set Distributions Ripley’s […]