Assessment of Structural Intolerance and Durability
General Structure Information 4h3b MAPK10 crystal structure of jnk3 in complex with sab peptide 2.08Å AUTH J.D.LAUGHLIN,J.C.NWACHUKWU,M.FIGUERA-LOSADA,L.CHERRY,AUTH 2 K.W.NETTLES,P.V.LOGRASSOTITL STRUCTURAL MECHANISMS OF ALLOSTERY AND AUTOINHIBITION IN JNKTITL 2 FAMILY KINASES.REF STRUCTURE V. 20 2174 2012REFN ISSN 0969-2126PMID 23142346DOI 10.1016/J.STR.2012.09.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hab PLK1 crystal structure of plk1 polo-box domain in complex with pl-49 2.65Å AUTH R.N.MURUGAN,J.E.PARK,D.LIM,M.AHN,C.CHEONG,T.KWON,K.Y.NAM,AUTH 2 S.H.CHOI,B.Y.KIM,D.Y.YOON,M.B.YAFFE,D.Y.YU,K.S.LEE,J.K.BANGTITL DEVELOPMENT OF CYCLIC PEPTOMER INHIBITORS TARGETING THETITL 2 POLO-BOX DOMAIN OF POLO-LIKE KINASE 1.REF BIOORG.MED.CHEM. V. 21 2623 2013REFN ISSN 0968-0896PMID 23498919DOI 10.1016/J.BMC.2013.02.020 Variant Set Distributions Mapped Variants
General Structure Information 3raw CLK3 crystal structure of human cdc-like kinase 3 isoform in complex with leucettine l41 2.09Å AUTH P.FILIPPAKOPOULOS,O.FEDOROV,O.KING,A.BULLOCK,J.R.C.MUNIZ,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 3 S.KNAPP,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN CDC-LIKE KINASE 3 ISOFORM WITH ATITL 2 BENZO-DIOXOL LIGANDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3p1i EPHB3 ligand binding domain of human ephrin type-b receptor 3 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,A.SEITOVA,J.KANIA,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL LIGAND BINDING DOMAIN OF HUMAN EPHB3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4eyc CAMP crystal structure of the cathelin-like domain of human cathelicidin ll-37 (hcld) 1.9Å AUTH M.PAZGIER,B.ERICKSEN,M.LING,E.TOTH,J.SHI,X.LI,AUTH 2 A.GALLIHER-BECKLEY,L.LAN,G.ZOU,C.ZHAN,W.YUAN,E.POZHARSKI,AUTH 3 W.LUTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE PRO-DOMAIN OFTITL 2 HUMAN CATHELICIDIN, LL-37.REF BIOCHEMISTRY V. 52 1547 2013REFN ISSN 0006-2960PMID 23406372DOI 10.1021/BI301008R Variant Set Distributions Mapped Variants
General Structure Information 2ayn USP14 structure of usp14, a proteasome-associated deubiquitinating enzyme 3.2Å AUTH M.HU,P.LI,L.SONG,P.D.JEFFREY,T.A.CHENOVA,AUTH 2 K.D.WILKINSON,R.E.COHEN,Y.SHITITL STRUCTURE AND MECHANISMS OF THETITL 2 PROTEASOME-ASSOCIATED DEUBIQUITINATING ENZYMETITL 3 USP14.REF EMBO J. V. 24 3747 2005REFN ISSN 0261-4189PMID 16211010DOI 10.1038/SJ.EMBOJ.7600832 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2olm AGFG1 arfgap domain of hiv-1 rev binding protein 1.48Å AUTH Y.TONG,W.TEMPEL,L.SHEN,S.DIMOV,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARK,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL ARFGAP DOMAIN OF HIV-1 REV BINDING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1pve RAD23B solution structure of xpc binding domain of hhr23b -1.0Å AUTH B.KIM,K.S.RYU,H.J.KIM,S.J.CHO,B.S.CHOITITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THETITL 2 XPC-BINDING DOMAIN OF THE HUMAN DNA REPAIR PROTEINTITL 3 HHR23B.REF FEBS J. V. 272 2467 2005REFN ISSN 1742-464XPMID 15885096DOI 10.1111/J.1742-4658.2005.04667.X Variant Set Distributions Mapped Variants
General Structure Information 1rm8 MMP16 crystal structure of the catalytic domain of mmp-16/mt3- mmp: characterization of mt-mmp specific features 1.8Å AUTH R.LANG,M.BRAUN,N.E.SOUNNI,A.NOEL,F.FRANKENNE,AUTH 2 J.M.FOIDART,W.BODE,K.MASKOSTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OFTITL 2 MMP-16/MT3-MMP: CHARACTERIZATION OF MT-MMPTITL 3 SPECIFIC FEATURES.REF J.MOL.BIOL. V. 336 213 2004REFN ISSN 0022-2836PMID 14741217DOI 10.1016/J.JMB.2003.12.022 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3qln ATRX crystal structure of atrx add domain in free state 1.9Å AUTH S.IWASE,B.XIANG,S.GHOSH,T.REN,P.W.LEWIS,J.C.COCHRANE,AUTH 2 C.D.ALLIS,D.J.PICKETTS,D.J.PATEL,H.LI,Y.SHITITL ATRX ADD DOMAIN LINKS AN ATYPICAL HISTONE METHYLATIONTITL 2 RECOGNITION MECHANISM TO HUMAN MENTAL-RETARDATION SYNDROMEREF NAT.STRUCT.MOL.BIOL. V. 18 769 2011REFN ISSN 1545-9993PMID 21666679DOI 10.1038/NSMB.2062 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]