Assessment of Structural Intolerance and Durability
General Structure Information 2lmi GRSF1 nmr structure of the protein bc040485 from homo sapiens -1.0Å AUTH S.K.DUTTA,P.SERRANO,M.GERALT,K.WUTHRICH,AUTH 2 JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 3 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL NMR STRUCTURE OF THE HUMAN RNA BINDING PROTEIN BC040485REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3rcq ASPH crystal structure of human aspartate beta-hydroxylase isoform a 2.05Å AUTH T.KROJER,G.KOCHAN,E.PILKA,V.HOZJAN,C.K.ALLERSTON,J.BRAY,AUTH 2 J.R.MUNIZ,A.CHAIKUAD,O.GILEADI,K.KAVANAGH,F.VON DELFT,AUTH 3 C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN ASPARTATE BETA-HYDROXYLASETITL 2 ISOFORM AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lg1 AKAP13 solution structure of the human akap13 ph domain and stabilizing dh helix -1.0Å AUTH M.LENOIR,M.SUGAWARA,J.KAUR,L.J.BALL,M.OVERDUINTITL STRUCTURAL INSIGHTS INTO THE ACTIVATION OF THE RHOA GTPASETITL 2 BY THE LBC ONCOPROTEIN.REF J.BIOL.CHEM. V. 3 215 2014REFN ISSN 0021-9258PMID 24993829DOI 10.1074/JBC.M114.561787 Variant Set Distributions Mapped Variants
General Structure Information 1nrv GRB10 crystal structure of the sh2 domain of grb10 1.65Å AUTH E.G.STEIN,R.GHIRLANDO,S.R.HUBBARDTITL STRUCTURAL BASIS FOR DIMERIZATION OF THE GRB10 SRCTITL 2 HOMOLOGY 2 DOMAIN. IMPLICATIONS FOR LIGANDTITL 3 SPECIFICITY.REF J.BIOL.CHEM. V. 278 13257 2003REFN ISSN 0021-9258PMID 12551896DOI 10.1074/JBC.M212026200 Variant Set Distributions Mapped Variants
General Structure Information 1fli FLI1 dna-binding domain of fli-1 -1.0Å AUTH H.LIANG,X.MAO,E.T.OLEJNICZAK,D.G.NETTESHEIM,L.YU,AUTH 2 R.P.MEADOWS,C.B.THOMPSON,S.W.FESIKTITL SOLUTION STRUCTURE OF THE ETS DOMAIN OF FLI-1 WHENTITL 2 BOUND TO DNA.REF NAT.STRUCT.BIOL. V. 1 871 1994REFN ISSN 1072-8368PMID 7773776DOI 10.1038/NSB1294-871 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1grn ARHGAP1 crystal structure of the cdc42/cdc42gap/alf3 complex. 2.1Å AUTH N.NASSAR,G.R.HOFFMAN,D.MANOR,J.C.CLARDY,R.A.CERIONETITL STRUCTURES OF CDC42 BOUND TO THE ACTIVE ANDTITL 2 CATALYTICALLY COMPROMISED FORMS OF CDC42GAP.REF NAT.STRUCT.BIOL. V. 5 1047 1998REFN ISSN 1072-8368PMID 9846874DOI 10.1038/4156 Variant Set Distributions Mapped Variants
General Structure Information 1grn ARHGAP1 crystal structure of the cdc42/cdc42gap/alf3 complex. 2.1Å AUTH N.NASSAR,G.R.HOFFMAN,D.MANOR,J.C.CLARDY,R.A.CERIONETITL STRUCTURES OF CDC42 BOUND TO THE ACTIVE ANDTITL 2 CATALYTICALLY COMPROMISED FORMS OF CDC42GAP.REF NAT.STRUCT.BIOL. V. 5 1047 1998REFN ISSN 1072-8368PMID 9846874DOI 10.1038/4156 Variant Set Distributions Mapped Variants