Assessment of Structural Intolerance and Durability
General Structure Information 1zkc PPIL2 crystal structure of the cyclophiln_ring domain of human peptidylprolyl isomerase (cyclophilin)-like 2 isoform b 1.65Å AUTH J.R.WALKER,T.DAVIS,E.M.NEWMAN,F.MACKENZIE,AUTH 2 J.WEIGELT,M.SUNDSTROM,C.ARROWSMITH,A.EDWARDS,AUTH 3 A.BOCHKAREV,S.DHE-PAGANON,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE HUMAN PEPTIDYLPROLYLTITL 2 ISOMERASE-LIKE 2 ISOFORM BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2kxs TJP1 zo1 zu5 domain in complex with grinl1a peptide -1.0Å AUTH L.HUO,W.WEN,R.WANG,C.KAM,J.XIA,W.FENG,M.ZHANGTITL CDC42-DEPENDENT FORMATION OF THE ZO-1/MRCKB COMPLEX AT THETITL 2 LEADING EDGE CONTROLS CELL MIGRATIONREF EMBO J. V. 30 665 2011REFN ISSN 0261-4189PMID 21240187DOI 10.1038/EMBOJ.2010.353 Variant Set Distributions Mapped Variants
General Structure Information 2pe4 HYAL1 structure of human hyaluronidase 1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis 2.0Å AUTH K.L.CHAO,L.MUTHUKUMAR,O.HERZBERGTITL STRUCTURE OF HUMAN HYALURONIDASE-1, A HYALURONAN HYDROLYZINGTITL 2 ENZYME INVOLVED IN TUMOR GROWTH AND ANGIOGENESISREF BIOCHEMISTRY V. 46 6911 2007REFN ISSN 0006-2960PMID 17503783DOI 10.1021/BI700382G Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2r3v MVK the biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism 2.5Å AUTH Z.FU,N.E.VOYNOVA,T.J.HERDENDORF,H.M.MIZIORKO,AUTH 2 J.J.KIMTITL BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACKTITL 2 INHIBITION OF MEVALONATE KINASE AND ISOPRENOIDTITL 3 METABOLISM.REF BIOCHEMISTRY V. 47 3715 2008REFN ISSN 0006-2960PMID 18302342DOI 10.1021/BI7024386 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2r3v MVK the biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism 2.5Å AUTH Z.FU,N.E.VOYNOVA,T.J.HERDENDORF,H.M.MIZIORKO,AUTH 2 J.J.KIMTITL BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACKTITL 2 INHIBITION OF MEVALONATE KINASE AND ISOPRENOIDTITL 3 METABOLISM.REF BIOCHEMISTRY V. 47 3715 2008REFN ISSN 0006-2960PMID 18302342DOI 10.1021/BI7024386 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2r3v MVK the biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism 2.5Å AUTH Z.FU,N.E.VOYNOVA,T.J.HERDENDORF,H.M.MIZIORKO,AUTH 2 J.J.KIMTITL BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACKTITL 2 INHIBITION OF MEVALONATE KINASE AND ISOPRENOIDTITL 3 METABOLISM.REF BIOCHEMISTRY V. 47 3715 2008REFN ISSN 0006-2960PMID 18302342DOI 10.1021/BI7024386 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1y3j ATP7A solution structure of the copper(i) form of the fifth domain of menkes protein -1.0Å AUTH L.BANCI,I.BERTINI,S.CIOFI-BAFFONI,C.T.CHASAPIS,AUTH 2 N.HADJILIADIS,A.ROSATOTITL AN NMR STUDY OF THE INTERACTION BETWEEN THE HUMANTITL 2 COPPER(I) CHAPERONE AND THE SECOND AND FIFTHTITL 3 METAL-BINDING DOMAINS OF THE MENKES PROTEINREF FEBS J. V. 272 865 2005REFN ISSN 1742-464XPMID […]
General Structure Information 1m3g DUSP2 solution structure of the catalytic domain of mapk phosphatase pac-1: insights into substrate-induced enzymatic activation -1.0Å AUTH A.FAROOQ,O.PLOTNIKOVA,G.CHATURVEDI,S.YAN,L.ZENG,AUTH 2 Q.ZHANG,M.-M.ZHOUTITL SOLUTION STRUCTURE OF THE MAPK PHOSPHATASE PAC-1TITL 2 CATALYTIC DOMAIN INSIGHTS INTO SUBSTRATE-INDUCEDTITL 3 ENZYMATIC ACTIVATION OF MKPREF STRUCTURE V. 11 155 2003REFN ISSN 0969-2126PMID 12575935DOI 10.1016/S0969-2126(02)00943-7 Variant Set Distributions […]
General Structure Information 3v5l ITK crystal structure of interleukin-2 inducible t-cell kinase itk catalytic domain with thienopyrazolylindole inhibitor 542 1.86Å AUTH L.R.MCLEAN,Y.ZHANG,N.ZAIDI,X.BI,R.WANG,R.DHARANIPRAGADA,AUTH 2 J.G.JURCAK,T.A.GILLESPY,Z.ZHAO,K.Y.MUSICK,Y.M.CHOI,AUTH 3 M.BARRAGUE,J.PEPPARD,M.SMICKER,M.DUGUID,A.PARKAR,J.FORDHAM,AUTH 4 D.KOMINOSTITL X-RAY CRYSTALLOGRAPHIC STRUCTURE-BASED DESIGN OF SELECTIVETITL 2 THIENOPYRAZOLE INHIBITORS FOR INTERLEUKIN-2-INDUCIBLETITL 3 TYROSINE KINASE.REF BIOORG.MED.CHEM.LETT. V. 22 3296 2012REFN ISSN 0960-894XPMID 22464456DOI 10.1016/J.BMCL.2012.03.016 Variant Set Distributions Ripley’s […]
General Structure Information 3w7r DHODH structure of human dihydroorotate dehydrogenase in complex with mii-4- 097 1.68Å AUTH D.K.INAOKA,M.IIDA,T.TABUCHI,N.LEE,S.HASHIMOTO,S.MATSUOKA,AUTH 2 T.KURANAGA,T.SHIBA,K.SAKAMOTO,S.SUZUKI,E.O.BALOGUN,T.NARA,AUTH 3 T.AOKI,M.INOUE,T.HONMA,A.TANAKA,S.HARADA,K.KITATITL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEXTITL 2 WITH MII-4-097REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants