Assessment of Structural Intolerance and Durability
General Structure Information 2q87 CD300A the crystal structure of the human irp60 ectodomain 1.7Å AUTH N.DIMASI,J.A.MARQUEZTITL THE CRYSTAL STRUCTURE OF IRP60 ECTODOMAINREF TO BE PUBLISHED 2007REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qwe GMIP crystal structure of the n-terminal domain of the gem interacting protein 2.4Å AUTH X.GUAN,W.TEMPEL,Y.TONG,L.SHEN,H.WANG,A.K.WERNIMONT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE GEMTITL 2 INTERACTING PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1d9n MBD1 solution structure of the methyl-cpg-binding domain of the methylation-dependent transcriptional repressor mbd1/pcm1 -1.0Å AUTH I.OHKI,N.SHIMOTAKE,N.FUJITA,M.NAKAO,M.SHIRAKAWATITL SOLUTION STRUCTURE OF THE METHYL-CPG-BINDINGTITL 2 DOMAIN OF THE METHYLATION-DEPENDENTTITL 3 TRANSCRIPTIONAL REPRESSOR MBD1.REF EMBO J. V. 18 6653 1999REFN ISSN 0261-4189PMID 10581239DOI 10.1093/EMBOJ/18.23.6653 Variant Set Distributions Mapped Variants
General Structure Information 1fb8 DAPP1 structure of the pleckstrin homology domain from dapp1/phish 2.4Å AUTH K.M.FERGUSON,J.M.KAVRAN,V.G.SANKARAN,E.FOURNIER,S.J.ISAKOFF,AUTH 2 E.Y.SKOLNIK,M.A.LEMMONTITL STRUCTURAL BASIS FOR DISCRIMINATION OF 3-PHOSPHOINOSITIDESTITL 2 BY PLECKSTRIN HOMOLOGY DOMAINS.REF MOL.CELL V. 6 373 2000REFN ISSN 1097-2765PMID 10983984DOI 10.1016/S1097-2765(00)00037-X Variant Set Distributions Mapped Variants
General Structure Information 3l82 FBXO4 x-ray crystal structure of trf1 and fbx4 complex 2.4Å AUTH Z.ZENG,W.WANG,Y.YANG,Y.CHEN,X.YANG,J.A.DIEHL,X.LIU,M.LEITITL STRUCTURAL BASIS OF SELECTIVE UBIQUITINATION OF TRF1 BYTITL 2 SCF(FBX4)REF DEV.CELL V. 18 214 2010REFN ISSN 1534-5807PMID 20159592DOI 10.1016/J.DEVCEL.2010.01.007 Variant Set Distributions Mapped Variants
General Structure Information 2ebw REV1 solution structure of the brct domain from human dna repair protein rev1 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BRCT DOMAIN FROM HUMANTITL 2 DNA REPAIR PROTEIN REV1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4lnz MYO5B crystal structure of human myosin 5b globular domain 3.11Å AUTH H.VELVARSKA,D.NIESSINGTITL STRUCTURAL INSIGHTS INTO THE GLOBULAR TAILS OF THE HUMANTITL 2 TYPE V MYOSINS MYO5A, MYO5B, AND MYO5C.REF PLOS ONE V. 8 82065 2013REFN ESSN 1932-6203PMID 24339992DOI 10.1371/JOURNAL.PONE.0082065 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3kjd PARP2 human poly(adp-ribose) polymerase 2, catalytic fragment in complex with an inhibitor abt-888 1.95Å AUTH T.KARLBERG,M.HAMMARSTROM,P.SCHUTZ,L.SVENSSON,H.SCHULERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PARP2 INTITL 2 COMPLEX WITH PARP INHIBITOR ABT-888.REF BIOCHEMISTRY V. 49 1056 2010REFN ISSN 0006-2960PMID 20092359DOI 10.1021/BI902079Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1m6d CTSF crystal structure of human cathepsin f 1.7Å AUTH J.R.SOMOZA,J.T.PALMER,J.D.HOTITL THE CRYSTAL STRUCTURE OF HUMAN CATHEPSIN F AND ITSTITL 2 IMPLICATIONS FOR THE DEVELOPMENT OF NOVEL IMMUNOMODULATORSREF J.MOL.BIOL. V. 322 559 2002REFN ISSN 0022-2836PMID 12225749DOI 10.1016/S0022-2836(02)00780-5 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lyr EBF1 human early b-cell factor 1 (ebf1) dna-binding domain 2.51Å AUTH M.I.SIPONEN,M.WISNIEWSKA,L.LEHTIO,I.JOHANSSON,L.SVENSSON,AUTH 2 G.RASZEWSKI,L.NILSSON,M.SIGVARDSSON,H.BERGLUNDTITL STRUCTURAL DETERMINATION OF FUNCTIONAL DOMAINS IN EARLYTITL 2 B-CELL FACTOR (EBF) FAMILY OF TRANSCRIPTION FACTORS REVEALSTITL 3 SIMILARITIES TO REL DNA-BINDING PROTEINS AND A NOVELTITL 4 DIMERIZATION MOTIF.REF J.BIOL.CHEM. V. 285 25875 2010REFN ISSN 0021-9258PMID 20592035DOI 10.1074/JBC.C110.150482 […]