Assessment of Structural Intolerance and Durability
General Structure Information 2dk3 HECTD1 solution structure of mib-herc2 domain in hect domain containing protein 1 -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF MIB-HERC2 DOMAIN IN HECTTITL 2 DOMAIN CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3kqg CD207 trimeric structure of langerin 2.3Å AUTH H.FEINBERG,A.S.POWLESLAND,M.E.TAYLOR,W.I.WEISTITL TRIMERIC STRUCTURE OF LANGERIN.REF J.BIOL.CHEM. V. 285 13285 2010REFN ISSN 0021-9258PMID 20181944DOI 10.1074/JBC.M109.086058 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i2r KCNIP1 crystal structure of the kchip1/kv4.3 t1 complex 3.35Å AUTH M.PIOLETTI,F.FINDEISEN,G.L.HURA,D.L.MINOR JR.TITL THREE-DIMENSIONAL STRUCTURE OF THE KCHIP1-KV4.3 T1 COMPLEXTITL 2 REVEALS A CROSS-SHAPED OCTAMERREF NAT.STRUCT.MOL.BIOL. V. 13 987 2006REFN ISSN 1545-9993PMID 17057713DOI 10.1038/NSMB1164 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kn6 PYCARD structure of full-length human asc (apoptosis-associated speck-like protein containing a card) -1.0Å AUTH E.DE ALBATITL STRUCTURE AND INTERDOMAIN DYNAMICS OF APOPTOSIS-ASSOCIATEDTITL 2 SPECK-LIKE PROTEIN CONTAINING A CARD (ASC)REF J.BIOL.CHEM. V. 284 32932 2009REFN ISSN 0021-9258PMID 19759015DOI 10.1074/JBC.M109.024273 Variant Set Distributions Mapped Variants
General Structure Information 3c5c RASL12 crystal structure of human ras-like, family 12 protein in complex with gdp 1.85Å AUTH L.SHEN,Y.TONG,W.TEMPEL,P.LOPPNAU,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAS-LIKE, FAMILY 12TITL 2 PROTEIN IN COMPLEX WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2c6u CLEC1B crystal structure of human clec-2 (clec1b) 1.6Å AUTH A.A.WATSON,J.BROWN,K.HARLOS,J.A.EBLE,T.S.WALTER,AUTH 2 C.A.OCALLAGHANTITL THE CRYSTAL STRUCTURE AND MUTATIONAL BINDINGTITL 2 ANALYSIS OF THE EXTRACELLULAR DOMAIN OF THETITL 3 PLATELET-ACTIVATING RECEPTOR CLEC-2.REF J.BIOL.CHEM. V. 282 3165 2007REFN ISSN 0021-9258PMID 17132623DOI 10.1074/JBC.M610383200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ydx MAT2B crystal structure of human s-adenosylmethionine synthetase 2, beta subunit 2.8Å AUTH N.SHAFQAT,J.R.C.MUNIZ,E.S.PILKA,E.PAPAGRIGORIOU,F.VON DELFT,AUTH 2 U.OPPERMANN,W.W.YUETITL INSIGHT INTO S-ADENOSYLMETHIONINE BIOSYNTHESIS FROM THETITL 2 CRYSTAL STRUCTURES OF THE HUMAN METHIONINETITL 3 ADENOSYLTRANSFERASE CATALYTIC AND REGULATORY SUBUNITS.REF BIOCHEM.J. V. 452 27 2013REFN ISSN 0264-6021PMID 23425511DOI 10.1042/BJ20121580 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4irq B4GALT7 crystal structure of catalytic domain of human beta1, 4galactosyltransferase 7 in closed conformation in complex with manganese and udp 2.3Å AUTH Y.TSUTSUI,B.RAMAKRISHNAN,P.K.QASBATITL CRYSTAL STRUCTURES OF BETA-1,4-GALACTOSYLTRANSFERASE 7TITL 2 ENZYME REVEAL CONFORMATIONAL CHANGES AND SUBSTRATE BINDING.REF J.BIOL.CHEM. V. 288 31963 2013REFN ISSN 0021-9258PMID 24052259DOI 10.1074/JBC.M113.509984 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2cq1 PTBP2 solution structure of rna binding domain in ptb-like protein l -1.0Å AUTH K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN INTITL 2 PTB-LIKE PROTEIN LREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3b94 TNFSF18 crystal structure of human gitrl 2.5Å AUTH X.M.SONG,Z.C.ZHOU,M.I.GREENETITL CRYSTAL STRUCTURE OF HUMAN GITRLREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants