Assessment of Structural Intolerance and Durability
General Structure Information 3qu6 IRF3 crystal structure of irf-3 dbd free form 2.3Å AUTH P.DE IOANNES,C.R.ESCALANTE,A.K.AGGARWALTITL STRUCTURES OF APO IRF-3 AND IRF-7 DNA BINDING DOMAINS:TITL 2 EFFECT OF LOOP L1 ON DNA BINDING.REF NUCLEIC ACIDS RES. V. 39 7300 2011REFN ISSN 0305-1048PMID 21596780DOI 10.1093/NAR/GKR325 Variant Set Distributions Mapped Variants
General Structure Information 1×69 CTTN solution structures of the sh3 domain of human src substrate cortactin -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SH3 DOMAIN OF HUMAN SRCTITL 2 SUBSTRATE CORTACTINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2p8q KPNB1 crystal structure of human importin beta bound to the snurportin1 ibb- domain 2.35Å AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2p8q KPNB1 crystal structure of human importin beta bound to the snurportin1 ibb- domain 2.35Å AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2p8q KPNB1 crystal structure of human importin beta bound to the snurportin1 ibb- domain 2.35Å AUTH G.MITROUSIS,A.S.OLIA,N.WALKER-KOPP,G.CINGOLANITITL MOLECULAR BASIS FOR THE RECOGNITION OF SNURPORTIN 1 BYTITL 2 IMPORTIN {BETA}.REF J.BIOL.CHEM. V. 283 7877 2008REFN ISSN 0021-9258PMID 18187419DOI 10.1074/JBC.M709093200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2efk TRIP10 crystal structure of the efc domain of cdc42-interacting protein 4 2.3Å AUTH A.SHIMADA,H.NIWA,K.TSUJITA,S.SUETSUGU,K.NITTA,AUTH 2 K.HANAWA-SUETSUGU,R.AKASAKA,Y.NISHINO,M.TOYAMA,L.CHEN,AUTH 3 Z.-J.LIU,B.-C.WANG,M.YAMAMOTO,T.TERADA,A.MIYAZAWA,A.TANAKA,AUTH 4 S.SUGANO,M.SHIROUZU,K.NAGAYAMA,T.TAKENAWA,S.YOKOYAMATITL CURVED EFC/F-BAR-DOMAIN DIMERS ARE JOINED END TO END INTO ATITL 2 FILAMENT FOR MEMBRANE INVAGINATION IN ENDOCYTOSISREF CELL(CAMBRIDGE,MASS.) V. 129 761 2007REFN ISSN 0092-8674PMID 17512409DOI 10.1016/J.CELL.2007.03.040 Variant Set Distributions Ripley’s K […]
General Structure Information 1g88 SMAD4 s4afl3arg515 mutant 3.0Å AUTH B.M.CHACKO,B.QIN,J.J.CORREIA,S.S.LAM,AUTH 2 M.P.DE CAESTECKER,K.LINTITL THE L3 LOOP AND C-TERMINAL PHOSPHORYLATION JOINTLYTITL 2 DEFINE SMAD PROTEIN TRIMERIZATION.REF NAT.STRUCT.BIOL. V. 8 248 2001REFN ISSN 1072-8368PMID 11224571DOI 10.1038/84995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2axl WRN solution structure of a multifunctional dna- and protein- binding domain of human werner syndrome protein -1.0Å AUTH J.-S.HU,H.FENG,W.ZENG,G.-X.LIN,X.G.XITITL SOLUTION STRUCTURE OF A MULTIFUNCTIONAL DNA- ANDTITL 2 PROTEIN-BINDING MOTIF OF HUMAN WERNER SYNDROMETITL 3 PROTEIN.REF PROC.NATL.ACAD.SCI.USA V. 102 18379 2005REFN ISSN 0027-8424PMID 16339893DOI 10.1073/PNAS.0509380102 Variant Set Distributions Mapped Variants
General Structure Information 2m0g SF1 structure, phosphorylation and u2af65 binding of the nterminal domain of splicing factor 1 during 3 splice site recognition -1.0Å AUTH Y.ZHANG,T.MADL,I.BAGDIUL,T.KERN,H.S.KANG,P.ZOU,N.MAUSBACHER,AUTH 2 S.A.SIEBER,A.KRAMER,M.SATTLERTITL STRUCTURE, PHOSPHORYLATION AND U2AF65 BINDING OF THETITL 2 N-TERMINAL DOMAIN OF SPLICING FACTOR 1 DURING 3-SPLICE SITETITL 3 RECOGNITION.REF NUCLEIC ACIDS RES. V. 41 1343 2013REFN ISSN […]
General Structure Information 4o9b STIM1 the structure of cc1-ih in human stim1. 2.6Å AUTH B.CUI,X.YANG,S.LI,Z.LIN,Z.WANG,C.DONG,Y.SHENTITL THE INHIBITORY HELIX CONTROLS THE INTRAMOLECULARTITL 2 CONFORMATIONAL SWITCHING OF THE C-TERMINUS OF STIM1.REF PLOS ONE V. 8 74735 2013REFN ESSN 1932-6203PMID 24069340DOI 10.1371/JOURNAL.PONE.0074735 Variant Set Distributions Mapped Variants