Assessment of Structural Intolerance and Durability
General Structure Information 2csv TRIM29 solution structure of the zf-b_box type2 domain of human tripartite motif protein trim29 isoform alpha -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-B_BOX TYPE2 DOMAIN OFTITL 2 HUMAN TRIPARTITE MOTIF PROTEIN TRIM29 ISOFORM ALPHAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3u7u ERBB4 crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta 3.03Å AUTH P.LIU,T.E.CLEVELAND,S.BOUYAIN,P.O.BYRNE,P.A.LONGO,D.J.LEAHYTITL A SINGLE LIGAND IS SUFFICIENT TO ACTIVATE EGFR DIMERS.REF PROC.NATL.ACAD.SCI.USA V. 109 10861 2012REFN ISSN 0027-8424PMID 22699492DOI 10.1073/PNAS.1201114109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3u3f PTK2B structural basis for the interaction of pyk2 pat domain with paxillin ld motifs 3.1Å AUTH M.S.VANAROTTI,D.J.MILLER,C.D.GUIBAO,A.NOURSE,J.J.ZHENGTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO THE INTERACTIONTITL 2 BETWEEN PYK2 AND PAXILLIN LD MOTIFS.REF J.MOL.BIOL. V. 426 3985 2014REFN ISSN 0022-2836PMID 25174335DOI 10.1016/J.JMB.2014.08.014 Variant Set Distributions Mapped Variants
General Structure Information 3bbt ERBB4 crystal structure of the erbb4 kinase in complex with lapatinib 2.8Å AUTH C.QIU,M.K.TARRANT,S.H.CHOI,A.SATHYAMURTHY,R.BOSE,S.BANJADE,AUTH 2 A.PAL,W.G.BORNMANN,M.A.LEMMON,P.A.COLE,D.J.LEAHYTITL MECHANISM OF ACTIVATION AND INHIBITION OF THE HER4/ERBB4TITL 2 KINASE.REF STRUCTURE V. 16 460 2008REFN ISSN 0969-2126PMID 18334220DOI 10.1016/J.STR.2007.12.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4awl NFYC the nf-y transcription factor is structurally and functionally a sequence specific histone 3.08Å AUTH M.NARDINI,N.GNESUTTA,G.DONATI,R.GATTA,C.FORNI,A.FOSSATI,AUTH 2 C.VONRHEIN,D.MORAS,C.ROMIER,M.BOLOGNESI,R.MANTOVANITITL SEQUENCE-SPECIFIC TRANSCRIPTION FACTOR NF-Y DISPLAYSTITL 2 HISTONE-LIKE DNA BINDING AND H2B-LIKE UBIQUITINATION.REF CELL(CAMBRIDGE,MASS.) V. 152 132 2013REFN ISSN 0092-8674PMID 23332751DOI 10.1016/J.CELL.2012.11.047 Variant Set Distributions Mapped Variants
General Structure Information 1xm9 PKP1 structure of the armadillo repeat domain of plakophilin 1 2.8Å AUTH H.J.CHOI,W.I.WEISTITL STRUCTURE OF THE ARMADILLO REPEAT DOMAIN OFTITL 2 PLAKOPHILIN 1.REF J.MOL.BIOL. V. 346 367 2005REFN ISSN 0022-2836PMID 15663951DOI 10.1016/J.JMB.2004.11.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ct4 TRIP10 solution strutcure of the sh3 domain of the cdc42- interacting protein 4 -1.0Å AUTH K.MIYAMOTO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUTCURE OF THE SH3 DOMAIN OF THETITL 2 CDC42-INTERACTING PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3q0n PUM1 crystal structure of the pumilio-homology domain from human pumilio1 in complex with erk2 nre 2.4Å AUTH G.LU,T.M.HALLTITL ALTERNATE MODES OF COGNATE RNA RECOGNITION BY HUMAN PUMILIOTITL 2 PROTEINS.REF STRUCTURE V. 19 361 2011REFN ISSN 0969-2126PMID 21397187DOI 10.1016/J.STR.2010.12.019 Variant Set Distributions Mapped Variants
General Structure Information 3q0n PUM1 crystal structure of the pumilio-homology domain from human pumilio1 in complex with erk2 nre 2.4Å AUTH G.LU,T.M.HALLTITL ALTERNATE MODES OF COGNATE RNA RECOGNITION BY HUMAN PUMILIOTITL 2 PROTEINS.REF STRUCTURE V. 19 361 2011REFN ISSN 0969-2126PMID 21397187DOI 10.1016/J.STR.2010.12.019 Variant Set Distributions Mapped Variants
General Structure Information 3q0n PUM1 crystal structure of the pumilio-homology domain from human pumilio1 in complex with erk2 nre 2.4Å AUTH G.LU,T.M.HALLTITL ALTERNATE MODES OF COGNATE RNA RECOGNITION BY HUMAN PUMILIOTITL 2 PROTEINS.REF STRUCTURE V. 19 361 2011REFN ISSN 0969-2126PMID 21397187DOI 10.1016/J.STR.2010.12.019 Variant Set Distributions Mapped Variants