Assessment of Structural Intolerance and Durability
General Structure Information 1qh5 HAGH human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione 1.45Å AUTH A.D.CAMERON,M.RIDDERSTROM,B.OLIN,B.MANNERVIKTITL CRYSTAL STRUCTURE OF HUMAN GLYOXALASE II AND ITS COMPLEXTITL 2 WITH A GLUTATHIONE THIOLESTER SUBSTRATE ANALOGUE.REF STRUCTURE FOLD.DES. V. 7 1067 1999REFN ISSN 0969-2126PMID 10508780DOI 10.1016/S0969-2126(99)80174-9 Variant Set Distributions Mapped Variants
General Structure Information 3vfq PARP14 human parp14 (artd8, bal2) – macro domains 1 and 2 in complex with adenosine-5-diphosphoribose 2.8Å AUTH A.H.FORST,T.KARLBERG,N.HERZOG,A.G.THORSELL,A.GROSS,AUTH 2 K.L.FEIJS,P.VERHEUGD,P.KURSULA,B.NIJMEIJER,E.KREMMER,AUTH 3 H.KLEINE,A.G.LADURNER,H.SCHULER,B.LUSCHERTITL RECOGNITION OF MONO-ADP-RIBOSYLATED ARTD10 SUBSTRATES BYTITL 2 ARTD8 MACRODOMAINS.REF STRUCTURE V. 21 462 2013REFN ISSN 0969-2126PMID 23473667DOI 10.1016/J.STR.2012.12.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3kvo HSDL2 crystal structure of the catalytic domain of human hydroxysteroid dehydrogenase like 2 (hsdl2) 2.25Å AUTH E.UGOCHUKWU,C.BHATIA,J.HUANG,E.PILKA,J.R.C.MUNIZ,A.C.W.PIKE,AUTH 2 T.KROJER,F.VON DELFT,E.M.VERDIN,U.OPPERMANN,K.L.KAVANAGHTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 HYDROXYSTEROID DEHYDROGENASE LIKE 2 (HSDL2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1jvg UAP1 crystal structure of human agx2 complexed with udpgalnac 2.3Å AUTH C.PENEFF,P.FERRARI,V.CHARRIER,Y.TABURET,C.MONNIER,AUTH 2 V.ZAMBONI,J.WINTER,M.HARNOIS,F.FASSY,Y.BOURNETITL CRYSTAL STRUCTURES OF TWO HUMAN PYROPHOSPHORYLASETITL 2 ISOFORMS IN COMPLEXES WITH UDPGLC(GAL)NAC: ROLE OFTITL 3 THE ALTERNATIVELY SPLICED INSERT IN THE ENZYMETITL 4 OLIGOMERIC ASSEMBLY AND ACTIVE SITE ARCHITECTURE.REF EMBO J. V. 20 6191 2001REFN ISSN 0261-4189PMID […]
General Structure Information 3u0v LYPLAL1 crystal structure analysis of human lyplal1 1.72Å AUTH M.BURGER,T.J.ZIMMERMANN,Y.KONDOH,P.STEGE,N.WATANABE,H.OSADA,AUTH 2 H.WALDMANN,I.R.VETTERTITL CRYSTAL STRUCTURE OF THE PREDICTED PHOSPHOLIPASE LYPLAL1TITL 2 REVEALS UNEXPECTED FUNCTIONAL PLASTICITY DESPITE CLOSETITL 3 RELATIONSHIP TO ACYL PROTEIN THIOESTERASESREF J.LIPID RES. V. 53 43 2012REFN ISSN 0022-2275PMID 22052940DOI 10.1194/JLR.M019851 Variant Set Distributions Mapped Variants
General Structure Information 2ic1 CDO1 crystal structure of human cysteine dioxygenase in complex with substrate cysteine 2.7Å AUTH S.YE,X.WU,L.WEI,D.TANG,P.SUN,M.BARTLAM,Z.RAOTITL AN INSIGHT INTO THE MECHANISM OF HUMAN CYSTEINETITL 2 DIOXYGENASE: KEY ROLES OF THE THIOETHER-BONDEDTITL 3 TYROSINE-CYSTEINE COFACTOR.REF J.BIOL.CHEM. V. 282 3391 2007REFN ISSN 0021-9258PMID 17135237DOI 10.1074/JBC.M609337200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2d8s MARCH8 solution structure of the ring domain of the human cellular modulator of immune recognition protein -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,T.TOMIZAWA,S.KOSHIBA,M.INOUE,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THE HUMANTITL 2 CELLULAR MODULATOR OF IMMUNE RECOGNITION PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2vcv GSTA3 glutathione transferase a3-3 in complex with glutathione and delta-4-androstene-3-17-dione 1.8Å AUTH K.TARS,B.OLIN,B.MANNERVIKTITL STRUCTURAL BASIS FOR FEATURING OF STEROID ISOMERASETITL 2 ACTIVITY IN ALPHA CLASS GLUTATHIONE TRANSFERASES.REF J.MOL.BIOL. V. 397 332 2010REFN ISSN 0022-2836PMID 20083122DOI 10.1016/J.JMB.2010.01.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3i7p DCAF12 crystal structure of ddb1 in complex with the h-box motif of wdr40a 3.0Å AUTH T.LI,E.I.ROBERT,P.C.VAN BREUGEL,M.STRUBIN,N.ZHENGTITL A PROMISCUOUS ALPHA-HELICAL MOTIF ANCHORS VIRALTITL 2 HIJACKERS AND SUBSTRATE RECEPTORS TO THE CUL4-DDB1TITL 3 UBIQUITIN LIGASE MACHINERY.REF NAT.STRUCT.MOL.BIOL. V. 17 105 2010REFN ISSN 1545-9993PMID 19966799DOI 10.1038/NSMB.1719 Variant Set Distributions Mapped Variants
General Structure Information 2vns STEAP3 crystal structure of the membrane proximal oxidoreductase domain of human steap3, the dominant ferric reductase of the erythroid transferrin cycle 2.0Å AUTH A.K.SENDAMARAI,R.S.OHGAMI,M.D.FLEMING,C.M.LAWRENCETITL STRUCTURE OF THE MEMBRANE PROXIMAL OXIDOREDUCTASETITL 2 DOMAIN OF HUMAN STEAP3, THE DOMINANTTITL 3 FERRIREDUCTASE OF THE ERYTHROID TRANSFERRIN CYCLEREF PROC.NATL.ACAD.SCI.USA V. 105 7410 2008REFN ISSN 0027-8424PMID […]