Assessment of Structural Intolerance and Durability
General Structure Information 2uzc PDLIM5 structure of human pdlim5 in complex with the c-terminal peptide of human alpha-actinin-1 1.5Å AUTH J.M.ELKINS,C.GILEADI,L.SHRESTHA,C.PHILLIPS,J.WANG,AUTH 2 J.R.C.MUNIZ,D.A.DOYLETITL UNUSUAL BINDING INTERACTIONS IN PDZ DOMAIN CRYSTALTITL 2 STRUCTURES HELP EXPLAIN BINDING MECHANISMS.REF PROTEIN SCI. V. 19 731 2010REFN ISSN 0961-8368PMID 20120020DOI 10.1002/PRO.349 Variant Set Distributions Mapped Variants
General Structure Information 3aj4 PLEKHB2 crystal structure of the ph domain of evectin-2 from human complexed with o-phospho-l-serine 1.0Å AUTH Y.UCHIDA,J.HASEGAWA,D.CHINNAPEN,T.INOUE,S.OKAZAKI,R.KATO,AUTH 2 S.WAKATSUKI,R.MISAKI,M.KOIKE,Y.UCHIYAMA,S.IEMURA,T.NATSUME,AUTH 3 R.KUWAHARA,T.NAKAGAWA,K.NISHIKAWA,K.MUKAI,E.MIYOSHI,AUTH 4 N.TANIGUCHI,D.SHEFF,W.I.LENCER,T.TAGUCHI,H.ARAITITL INTRACELLULAR PHOSPHATIDYLSERINE IS ESSENTIAL FOR RETROGRADETITL 2 MEMBRANE TRAFFIC THROUGH ENDOSOMESREF PROC.NATL.ACAD.SCI.USA V. 108 15846 2011REFN ISSN 0027-8424PMID 21911378DOI 10.1073/PNAS.1109101108 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1bpv TTN titin module a71 from human cardiac muscle, nmr, 50 structures -1.0Å AUTH C.M.GOLL,A.PASTORE,M.NILGESTITL THE THREE-DIMENSIONAL STRUCTURE OF A TYPE I MODULETITL 2 FROM TITIN: A PROTOTYPE OF INTRACELLULARTITL 3 FIBRONECTIN TYPE III DOMAINS.REF STRUCTURE V. 6 1291 1998REFN ISSN 0969-2126PMID 9782056DOI 10.1016/S0969-2126(98)00129-4 Variant Set Distributions Mapped Variants
General Structure Information 2zme SNF8 integrated structural and functional model of the human escrt-ii complex 2.9Å AUTH Y.J.IM,J.H.HURLEYTITL INTEGRATED STRUCTURAL MODEL AND MEMBRANE TARGETING MECHANISMTITL 2 OF THE HUMAN ESCRT-II COMPLEXREF DEV.CELL V. 14 902 2008REFN ISSN 1534-5807PMID 18539118DOI 10.1016/J.DEVCEL.2008.04.004 Variant Set Distributions Mapped Variants
General Structure Information 2pd6 HSD17B8 structure of human hydroxysteroid dehydrogenase type 8, hsd17b8 2.0Å AUTH A.P.TURNBULL,E.SALAH,O.GILEADI,P.SAVITSKY,K.GUO,G.BUNKOCZI,AUTH 2 A.C.W.PIKE,E.UGOCHUKWU,C.UMEANO,F.VON DELFT,J.WEIGELT,AUTH 3 C.H.ARROWSMITH,M.SUNDSTROM,A.EDWARDS,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL STRUCTURE OF HUMAN HYDROXYSTEROID DEHYDROGENASE TYPE 8,TITL 2 HSD17B8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3siu PRPF31 structure of a hprp31-15.5k-u4atac 5 stem loop complex, monomeric form 2.63Å AUTH S.LIU,H.GHALEI,R.LUHRMANN,M.C.WAHLTITL STRUCTURAL BASIS FOR THE DUAL U4 AND U4ATAC SNRNA-BINDINGTITL 2 SPECIFICITY OF SPLICEOSOMAL PROTEIN HPRP31.REF RNA V. 17 1655 2011REFN ISSN 1355-8382PMID 21784869DOI 10.1261/RNA.2690611 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f8v TTN structure of full length telethonin in complex with the n-terminus of titin 2.75Å AUTH N.PINOTSIS,M.PETOUKHOV,S.LANGE,D.SVERGUN,P.ZOU,M.GAUTEL,AUTH 2 M.WILMANNSTITL EVIDENCE FOR A DIMERIC ASSEMBLY OF TWO TITIN/TELETHONINTITL 2 COMPLEXES INDUCED BY THE TELETHONIN C-TERMINUS.REF J.STRUCT.BIOL. V. 155 239 2006REFN ISSN 1047-8477PMID 16713295DOI 10.1016/J.JSB.2006.03.028 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3zkj ASB9 crystal structure of ankyrin repeat and socs box-containing protein 9 (asb9) in complex with elonginb and elonginc 2.58Å AUTH J.R.C.MUNIZ,K.GUO,N.J.KERSHAW,V.AYINAMPUDI,F.VON DELFT,AUTH 2 J.J.BABON,A.N.BULLOCKTITL MOLECULAR ARCHITECTURE OF THE ANKYRIN SOCS BOX FAMILY OFTITL 2 CUL5-DEPENDENT E3 UBIQUITIN LIGASESREF J.MOL.BIOL. V. 425 3166 2013REFN ISSN 0022-2836PMID 23806657DOI 10.1016/J.JMB.2013.06.015 Variant Set Distributions Ripley’s […]
General Structure Information 4jgh CUL5 structure of the socs2-elongin bc complex bound to an n-terminal fragment of cullin5 3.0Å AUTH Y.K.KIM,M.J.KWAK,B.KU,H.Y.SUH,K.JOO,J.LEE,J.U.JUNG,B.H.OHTITL STRUCTURAL BASIS OF INTERSUBUNIT RECOGNITION IN ELONGINTITL 2 BC-CULLIN 5-SOCS BOX UBIQUITIN-PROTEIN LIGASE COMPLEXES.REF ACTA CRYSTALLOGR.,SECT.D V. 69 1587 2013REFN ISSN 0907-4449PMID 23897481DOI 10.1107/S0907444913011220 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4fp9 NSUN4 human mterf4-nsun4 protein complex 2.9Å AUTH H.SPAHR,B.HABERMANN,C.M.GUSTAFSSON,N.G.LARSSON,B.M.HALLBERGTITL STRUCTURE OF THE HUMAN MTERF4-NSUN4 PROTEIN COMPLEX THATTITL 2 REGULATES MITOCHONDRIAL RIBOSOME BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 109 15253 2012REFN ISSN 0027-8424PMID 22949673DOI 10.1073/PNAS.1210688109 Variant Set Distributions Mapped Variants