Assessment of Structural Intolerance and Durability
General Structure Information 3ber DDX47 human dead-box rna-helicase ddx47, conserved domain i in complex with amp 1.4Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Mapped Variants
General Structure Information 3f6k SORT1 crystal structure of the vps10p domain of human sortilin/nts3 in complex with neurotensin 2.0Å AUTH E.M.QUISTGAARD,P.MADSEN,M.K.GROFTEHAUGE,P.NISSEN,AUTH 2 C.M.PETERSEN,S.S.THIRUPTITL LIGANDS BIND TO SORTILIN IN THE TUNNEL OF A TEN-BLADEDTITL 2 BETA-PROPELLER DOMAIN.REF NAT.STRUCT.MOL.BIOL. V. 16 96 2009REFN ISSN 1545-9993PMID 19122660DOI 10.1038/NSMB.1543 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2kv3 REG4 human regenerating gene type iv (reg iv) protein, p91s mutant -1.0Å AUTH M.HO,Y.LOU,S.WEI,S.LUO,W.LIN,P.LYU,C.CHENTITL HUMAN REGIV PROTEIN ADOPTS A TYPICAL C-TYPE LECTIN FOLD BUTTITL 2 BINDS MANNAN WITH TWO CALCIUM-INDEPENDENT SITESREF J.MOL.BIOL. 2010REFN ESSN 1089-8638DOI 10.1016/J.JMB.2010.07.061 Variant Set Distributions Mapped Variants
General Structure Information 1nd7 WWP1 conformational flexibility underlies ubiquitin ligation mediated by the wwp1 hect domain e3 ligase 2.1Å AUTH M.A.VERDECIA,C.A.P.JOAZIERO,N.J.WELLS,J.-L.FERRER,AUTH 2 M.E.BOWMAN,T.HUNTER,J.P.NOELTITL CONFORMATIONAL FLEXIBILITY UNDERLIES UBIQUITINTITL 2 LIGATION MEDIATED BY THE WWP1 HECT DOMAIN E3 LIGASEREF MOL.CELL V. 11 249 2003REFN ISSN 1097-2765PMID 12535537DOI 10.1016/S1097-2765(02)00774-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2bka HTATIP2 cc3(tip30)crystal strucure 1.7Å AUTH K.EL OMARI,L.E.BIRD,C.E.NICHOLS,J.REN,D.K.STAMMERSTITL CRYSTAL STRUCTURE OF CC3 (TIP30): IMPLICATIONS FORTITL 2 ITS ROLE AS A TUMOR SUPPRESSORREF J.BIOL.CHEM. V. 280 18229 2005REFN ISSN 0021-9258PMID 15728189DOI 10.1074/JBC.M501113200 Variant Set Distributions Mapped Variants
General Structure Information 3n1g BOC crystal structure of dhhn bound to bocfn3 1.9Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Mapped Variants
General Structure Information 2jrf TPPP3 solution nmr structure of tubulin polymerization-promoting protein family member 3 from homo sapiens. northeast structural genomics target hr387. -1.0Å AUTH J.M.ARAMINI,P.ROSSI,R.SHASTRY,C.NWOSU,K.CUNNINGHAM,AUTH 2 R.XIAO,J.LIU,M.C.BARAN,P.K.RAJAN,T.B.ACTON,B.ROST,AUTH 3 G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF TUBULINTITL 2 POLYMERIZATION-PROMOTING PROTEIN FAMILY MEMBER 3TITL 3 FROM HOMO SAPIENS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4nsc MICU1 crystal structure of cbara1 in the apo-form 3.2Å AUTH L.WANG,X.YANG,S.LI,Z.WANG,Y.LIU,J.FENG,Y.ZHU,Y.SHENTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO MICU1 REGULATION OFTITL 2 MITOCHONDRIAL CALCIUM UPTAKE.REF EMBO J. V. 33 594 2014REFN ISSN 0261-4189PMID 24514027DOI 10.1002/EMBJ.201386523 Variant Set Distributions Mapped Variants
General Structure Information 1r8u CITED2 nmr structure of cbp taz1/cited2 complex -1.0Å AUTH R.N.DE GUZMAN,M.A.MARTINEZ-YAMOUT,H.J.DYSON,AUTH 2 P.E.WRIGHTTITL INTERACTION OF THE TAZ1 DOMAIN OF THE CREB-BINDINGTITL 2 PROTEIN WITH THE ACTIVATION DOMAIN OF CITED2:TITL 3 REGULATION BY COMPETITION BETWEEN INTRINSICALLYTITL 4 UNSTRUCTURED LIGANDS FOR NON-IDENTICAL BINDINGTITL 5 SITES.REF J.BIOL.CHEM. V. 279 3042 2004REFN ISSN 0021-9258PMID 14594809DOI […]
General Structure Information 3nw0 NDNL2 crystal structure of mageg1 and nse1 complex 2.92Å AUTH J.M.DOYLE,J.GAO,J.WANG,M.YANG,P.R.POTTSTITL MAGE-RING PROTEIN COMPLEXES COMPRISE A FAMILY OF E3TITL 2 UBIQUITIN LIGASES.REF MOL.CELL V. 39 963 2010REFN ISSN 1097-2765PMID 20864041DOI 10.1016/J.MOLCEL.2010.08.029 Variant Set Distributions Mapped Variants