Assessment of Structural Intolerance and Durability
General Structure Information 2mkf UIMC1 solution structure of the e81 deletion mutant of the tandem uims of rap80 -1.0Å AUTH ANAMIKA,C.J.MARKIN,M.K.ROUT,L.SPYRACOPOULOSTITL MOLECULAR BASIS FOR IMPAIRED DNA DAMAGE RESPONSE FUNCTIONTITL 2 ASSOCIATED WITH THE RAP80 DELTA E81 DEFECT.REF J.BIOL.CHEM. V. 289 12852 2014REFN ISSN 0021-9258PMID 24627472DOI 10.1074/JBC.M113.538280 Variant Set Distributions Mapped Variants
General Structure Information 2z0v SH3GL3 crystal structure of bar domain of endophilin-iii 2.49Å AUTH K.MURAYAMA,M.KATO-MURAYAMA,T.TERADA,M.SHIROUZU,AUTH 2 S.YOKOYAMATITL CRYSTAL STRUCTURE OF BAR DOMAIN OF ENDOPHILIN-IIIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ewf HDAC8 crystal structure analysis of human hdac8 h143a variant complexed with substrate. 2.5Å AUTH D.P.DOWLING,S.L.GANTT,S.G.GATTIS,C.A.FIERKE,AUTH 2 D.W.CHRISTIANSONTITL STRUCTURAL STUDIES OF HUMAN HISTONE DEACETYLASE 8TITL 2 AND ITS SITE-SPECIFIC VARIANTS COMPLEXED WITHTITL 3 SUBSTRATE AND INHIBITORS.REF BIOCHEMISTRY V. 47 13554 2008REFN ISSN 0006-2960PMID 19053282DOI 10.1021/BI801610C Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 3tvl THTPA complex between the human thiamine triphosphatase and triphosphate 2.3Å AUTH D.DELVAUX,F.KERFF,M.R.MURTY,B.LAKAYE,J.CZERNIECKI,G.KOHN,AUTH 2 P.WINS,R.HERMAN,V.GABELICA,F.HEUZE,X.TORDOIR,R.MAREE,AUTH 3 A.MATAGNE,P.CHARLIER,E.DE PAUW,L.BETTENDORFFTITL STRUCTURAL DETERMINANTS OF SPECIFICITY AND CATALYTICTITL 2 MECHANISM IN MAMMALIAN 25-KDA THIAMINE TRIPHOSPHATASE.REF BIOCHIM.BIOPHYS.ACTA V.1830 4513 2013REFN ISSN 0006-3002PMID 23707715DOI 10.1016/J.BBAGEN.2013.05.014 Variant Set Distributions Mapped Variants
General Structure Information 2o2k MTR crystal structure of the activation domain of human methionine synthase isoform/mutant d963e/k1071n 1.6Å AUTH K.R.WOLTHERS,H.S.TOOGOOD,T.A.JOWITT,K.R.MARSHALL,AUTH 2 D.LEYS,N.S.SCRUTTONTITL CRYSTAL STRUCTURE AND SOLUTION CHARACTERIZATION OFTITL 2 THE ACTIVATION DOMAIN OF HUMAN METHIONINE SYNTHASEREF FEBS J. V. 274 738 2007REFN ISSN 1742-464XPMID 17288554DOI 10.1111/J.1742-4658.2006.05618.X Variant Set Distributions Mapped Variants
General Structure Information 2kpk MAGI1 magi-1 pdz1 -1.0Å AUTH S.CHARBONNIER,Y.NOMINE,J.RAMIREZ,K.LUCK,A.CHAPELLE,AUTH 2 R.H.STOTE,G.TRAVE,B.KIEFFER,R.A.ATKINSONTITL THE STRUCTURAL AND DYNAMIC RESPONSE OF MAGI-1 PDZ1 WITHTITL 2 NON-CANONICAL DOMAIN BOUNDARIES TO BINDING OF HUMANTITL 3 PAPILLOMAVIRUS (HPV) E6REF J.MOL.BIOL. 2011REFN ESSN 1089-8638PMID 21238461DOI 10.1016/J.JMB.2011.01.015 Variant Set Distributions Mapped Variants
General Structure Information 1d5v FOXC2 solution structure of the forkhead domain of the adipocyte- transcription factor freac-11 (s12) -1.0Å AUTH M.J.VAN DONGEN,A.CEDERBERG,P.CARLSSON,S.ENERBACK,AUTH 2 M.WIKSTROMTITL SOLUTION STRUCTURE AND DYNAMICS OF THE DNA-BINDINGTITL 2 DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTORTITL 3 FREAC-11.REF J.MOL.BIOL. V. 296 351 2000REFN ISSN 0022-2836PMID 10669593DOI 10.1006/JMBI.1999.3476 Variant Set Distributions Mapped Variants
General Structure Information 1nut NMNAT3 crystal structure of human cytosolic nmn/namn adenylyltransferase complexed with atp analog 1.9Å AUTH X.ZHANG,O.V.KURNASOV,S.KARTHIKEYAN,N.V.GRISHIN,A.L.OSTERMAN,AUTH 2 H.ZHANGTITL STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NAMNTITL 2 ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NADTITL 3 BIOSYNTHESISREF J.BIOL.CHEM. V. 278 13503 2003REFN ISSN 0021-9258PMID 12574164DOI 10.1074/JBC.M300073200 Variant Set Distributions Mapped Variants
General Structure Information 4lhy RAB3IP crystal structure of gdp-bound rab8:rabin8 3.1Å AUTH Z.GUO,X.HOU,R.S.GOODY,A.ITZENTITL INTERMEDIATES IN THE GUANINE NUCLEOTIDE EXCHANGE REACTION OFTITL 2 RAB8 PROTEIN CATALYZED BY GUANINE NUCLEOTIDE EXCHANGETITL 3 FACTORS RABIN8 AND GRAB.REF J.BIOL.CHEM. V. 288 32466 2013REFN ISSN 0021-9258PMID 24072714DOI 10.1074/JBC.M113.498329 Variant Set Distributions Mapped Variants
General Structure Information 2×47 MACROD1 crystal structure of human macrod1 1.7Å AUTH D.CHEN,M.VOLLMAR,M.N.ROSSI,C.PHILLIPS,R.KRAEHENBUEHL,AUTH 2 D.SLADE,P.V.MEHROTRA,F.VON DELFT,S.K.CROSTHWAITE,O.GILEADI,AUTH 3 J.M.DENU,I.AHELTITL IDENTIFICATION OF MACRO DOMAIN PROTEINS AS NOVEL O-TITL 2 ACETYL-ADP-RIBOSE DEACETYLASES.REF J.BIOL.CHEM. V. 286 13261 2011REFN ISSN 0021-9258PMID 21257746DOI 10.1074/JBC.M110.206771 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants