Assessment of Structural Intolerance and Durability
General Structure Information 2xv7 FIGF crystal structure of vascular endothelial growth factor d 2.9Å AUTH V.M.LEPPANEN,M.JELTSCH,A.ANISIMOV,D.TVOROGOV,K.AHO,AUTH 2 N.KALKKINEN,P.TOIVANEN,S.YLA-HERTTUALA,K.BALLMER-HOFER,AUTH 3 K.ALITALOTITL STRUCTURAL DETERMINANTS OF VASCULAR ENDOTHELIAL GROWTHTITL 2 FACTOR-D – RECEPTOR BINDING AND SPECIFICITY.REF BLOOD V. 117 1507 2011REFN ISSN 0006-4971PMID 21148085DOI 10.1182/BLOOD-2010-08-301549 Variant Set Distributions Mapped Variants
General Structure Information 3kfv TJP3 crystal structure of the sh3-kinase fragment of tight junction protein 3 (tjp3) in apo-form 2.8Å AUTH Y.TONG,L.NEDYALKOVA,W.TEMPEL,N.ZHONG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE SH3-KINASE FRAGMENT OFTITL 2 TIGHT JUNCTION PROTEIN 3 (TJP3) IN APO-FORMREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dal PRDM1 methyltransferase domain of human pr domain-containing protein 1 1.65Å AUTH H.ZENG,M.F.AMAYA,T.ANTOSHENKO,A.DONG,P.LOPPNAU,AUTH 2 A.BOCHKAREV,J.MIN,A.N.PLOTNIKOV,H.WUTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAINTITL 2 OF HUMAN PR DOMAIN-CONTAINING PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lx7 GAS7 solution nmr structure of sh3 domain of growth arrest-specific protein 7 (gas7) (fragment 1-60) from homo sapiens, northeast structural genomics consortium (nesg) target hr8574a -1.0Å AUTH Y.YANG,T.A.RAMELOT,L.DAN,E.KOHAN,H.JANJUA,R.XIAO,T.ACTON,AUTH 2 J.K.EVERETT,G.T.MONTELIONE,M.A.KENNEDYTITL SOLUTION NMR STRUCTURE OF SH3 DOMAIN OF GROWTHTITL 2 ARREST-SPECIFIC PROTEIN 7 (GAS7) (FRAGMENT 1-60) FROM HOMOTITL 3 SAPIENS, NORTHEAST STRUCTURAL […]
General Structure Information 2l0t STAM2 solution structure of the complex of ubiquitin and the vhs domain of stam2 -1.0Å AUTH A.LANGE,D.HOELLER,H.WIENK,O.MARCILLAT,J.M.LANCELIN,O.WALKERTITL NMR REVEALS A DIFFERENT MODE OF BINDING OF THE STAM2 VHSTITL 2 DOMAIN TO UBIQUITIN AND DIUBIQUITIN.REF BIOCHEMISTRY V. 50 48 2011REFN ISSN 0006-2960PMID 21121635DOI 10.1021/BI101594A Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3zhf AP1G2 gamma 2 adaptin ear domain crystal structure with pres1 site1 peptide npdwdfn 1.7Å AUTH M.C.JURGENS,J.VOROS,G.J.P.RAUTUREAU,D.A.SHEPHERD,V.E.PYE,AUTH 2 J.MULDOON,C.M.JOHNSON,A.E.ASHCROFT,S.M.V.FREUND,N.FERGUSONTITL THE HEPATITIS B VIRUS PRES1 DOMAIN HIJACKS HOST TRAFFICKINGTITL 2 PROTEINS BY MOTIF MIMICRY.REF NAT.CHEM.BIOL. V. 9 540 2013REFN ISSN 1552-4450PMID 23851574DOI 10.1038/NCHEMBIO.1294 Variant Set Distributions Mapped Variants
General Structure Information 1vzo RPS6KA5 the structure of the n-terminal kinase domain of msk1 reveals a novel autoinhibitory conformation for a dual kinase protein 1.8Å AUTH K.J.SMITH,P.S.CARTER,A.BRIDGES,P.HORROCKS,C.LEWIS,AUTH 2 G.PETTMAN,A.CLARKE,M.BROWN,J.HUGHES,M.WILKINSON,AUTH 3 B.BAX,A.REITHTITL THE STRUCTURE OF MSK1 REVEALS A NOVELTITL 2 AUTOINHIBITORY CONFORMATION FOR A DUAL KINASETITL 3 PROTEINREF STRUCTURE V. 12 1066 2004REFN ISSN 0969-2126PMID 15274926DOI […]
General Structure Information 3lju ADAP1 crystal structure of full length centaurin alpha-1 bound with the head group of pip3 1.7Å AUTH Y.TONG,W.TEMPEL,H.WANG,K.YAMADA,L.SHEN,G.A.SENISTERRA,AUTH 2 F.MACKENZIE,A.H.CHISHTI,H.W.PARKTITL PHOSPHORYLATION-INDEPENDENT DUAL-SITE BINDING OF THE FHATITL 2 DOMAIN OF KIF13 MEDIATES PHOSPHOINOSITIDE TRANSPORT VIATITL 3 CENTAURIN ALPHA1.REF PROC.NATL.ACAD.SCI.USA V. 107 20346 2010REFN ISSN 0027-8424PMID 21057110DOI 10.1073/PNAS.1009008107 Variant Set Distributions Ripley’s K […]
General Structure Information 2ytx CSDE1 solution structure of the second cold-shock domain of the human kiaa0885 protein (unr protein) -1.0Å AUTH A.K.GORONCY,S.KOSHIBA,N.TOCHIO,T.TOMIZAWA,M.INOUE,AUTH 2 S.WATANABE,T.HARADA,A.TANAKA,O.OHARA,T.KIGAWA,S.YOKOYAMATITL THE NMR SOLUTION STRUCTURES OF THE FIVE CONSTITUENTTITL 2 COLD-SHOCK DOMAINS (CSD) OF THE HUMAN UNR (UPSTREAM OFTITL 3 N-RAS) PROTEIN.REF J.STRUCT.FUNCT.GENOM. V. 11 181 2010REFN ISSN 1345-711XPMID 20213426DOI 10.1007/S10969-010-9081-Z Variant […]
General Structure Information 1rgw LDB3 solution structure of zasps pdz domain -1.0Å AUTH Y.AU,R.A.ATKINSON,R.GUERRINI,G.KELLY,C.JOSEPH,AUTH 2 S.R.MARTIN,F.W.MUSKETT,A.PALLAVICINI,G.FAULKNER,AUTH 3 A.PASTORETITL SOLUTION STRUCTURE OF ZASP PDZ DOMAIN;TITL 2 IMPLICATIONS FOR SARCOMERE ULTRASTRUCTURE ANDTITL 3 ENIGMA FAMILY REDUNDANCY.REF STRUCTURE V. 12 611 2004REFN ISSN 0969-2126PMID 15062084DOI 10.1016/J.STR.2004.02.019 Variant Set Distributions Mapped Variants