Assessment of Structural Intolerance and Durability
General Structure Information 2f15 PRKAB2 glycogen-binding domain of the amp-activated protein kinase beta2 subunit 2.0Å AUTH J.R.WALKER,L.WYBENGA-GROOT,P.J.FINERTY JR.,AUTH 2 E.NEWMAN,F.M.MACKENZIE,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.ARROWSMITH,A.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE GLYCOGEN-BINDING DOMAIN OF THETITL 2 AMP-ACTIVATED PROTEIN KINASE BETA2 SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3nby SNUPN crystal structure of the pki nes-crm1-rangtp nuclear export complex 3.42Å AUTH T.GUTTLER,T.MADL,P.NEUMANN,D.DEICHSEL,L.CORSINI,T.MONECKE,AUTH 2 R.FICNER,M.SATTLER,D.GORLICHTITL NES CONSENSUS REDEFINED BY STRUCTURES OF PKI-TYPE ANDTITL 2 REV-TYPE NUCLEAR EXPORT SIGNALS BOUND TO CRM1.REF NAT.STRUCT.MOL.BIOL. V. 17 1367 2010REFN ISSN 1545-9993PMID 20972448DOI 10.1038/NSMB.1931 Variant Set Distributions Mapped Variants
General Structure Information 4d90 EDIL3 crystal structure of del-1 egf domains 2.6Å AUTH T.SCHURPF,Q.CHEN,J.H.LIU,R.WANG,T.A.SPRINGER,J.H.WANGTITL THE RGD FINGER OF DEL-1 IS A UNIQUE STRUCTURAL FEATURETITL 2 CRITICAL FOR INTEGRIN BINDING.REF FASEB J. V. 26 3412 2012REFN ISSN 0892-6638PMID 22601780DOI 10.1096/FJ.11-202036 Variant Set Distributions Mapped Variants
General Structure Information 2wal GADD45G crystal structure of human gadd45gamma 2.4Å AUTH S.BHATTACHARYA,J.J.MUELLER,Y.ROSKE,A.P.TURNBULL,C.QUEDENAU,AUTH 2 F.GOTZ,K.BUSSOW,U.HEINEMANNTITL THE CRYSTAL STRUCTURE OF HUMAN GADD45GAMMAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dj7 ABLIM3 solution structure of 3rd lim domain of actin-binding lim protein 3 -1.0Å AUTH T.N.NIRAULA,A.SASAGAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF 3RD LIM DOMAIN OFTITL 2 ACTIN-BINDING LIM PROTEIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3s24 RNGTT crystal structure of human mrna guanylyltransferase 3.01Å AUTH C.CHU,K.DAS,J.R.TYMINSKI,J.D.BAUMAN,R.GUAN,W.QIU,AUTH 2 G.T.MONTELIONE,E.ARNOLD,A.J.SHATKINTITL STRUCTURE OF THE GUANYLYLTRANSFERASE DOMAIN OF HUMAN MRNATITL 2 CAPPING ENZYME.REF PROC.NATL.ACAD.SCI.USA V. 108 10104 2011REFN ISSN 0027-8424PMID 21636784DOI 10.1073/PNAS.1106610108 Variant Set Distributions Mapped Variants
General Structure Information 3b7x FKBP6 crystal structure of human fk506-binding protein 6 2.1Å AUTH J.R.WALKER,T.DAVIS,C.BUTLER-COLE,R.PARAMANATHAN,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL HUMAN FK506-BINDING PROTEIN 6.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4krs TNKS tankyrase-1 complexed with small molecule inhibitor 2.29Å AUTH M.D.SHULTZ,D.MAJUMDAR,D.N.CHIN,P.D.FORTIN,Y.FENG,T.GOULD,AUTH 2 C.A.KIRBY,T.STAMS,N.J.WATERS,W.SHAOTITL STRUCTURE-EFFICIENCY RELATIONSHIP OFTITL 2 [1,2,4]TRIAZOL-3-YLAMINES AS NOVEL NICOTINAMIDE ISOSTERESTITL 3 THAT INHIBIT TANKYRASES.REF J.MED.CHEM. V. 56 7049 2013REFN ISSN 0022-2623PMID 23879431DOI 10.1021/JM400826J Variant Set Distributions Mapped Variants
General Structure Information 4n68 CNTN5 crystal structure of an internal fn3 domain from human contactin-5 [psi-nysgrc-005804] 1.8Å AUTH P.R.KUMAR,A.CASADEVALL,S.C.ALMOTITL CRYSTAL STRUCTURE OF AN INTERNAL FN3 DOMAIN FROM HUMANTITL 2 CONTACTIN-5 [PSI-NYSGRC-005804]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4cai DYSF structure of inner dysf domain of human dysferlin 2.2Å AUTH A.SULA,A.R.COLE,C.YEATS,C.ORENGO,N.H.KEEPTITL CRYSTAL STRUCTURES OF THE HUMAN DYSFERLIN INNER DYSF DOMAINREF BMC STRUCT.BIOL. V. 14 3 2014REFN ISSN 1472-6807PMID 24438169DOI 10.1186/1472-6807-14-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants