4KRS.A | TNKS

General Structure Information

PDB ID 4krs
HGNC Gene Label(s) TNKS
Structure Name tankyrase-1 complexed with small molecule inhibitor
Resolution 2.29Å
Reference AUTH M.D.SHULTZ,D.MAJUMDAR,D.N.CHIN,P.D.FORTIN,Y.FENG,T.GOULD,AUTH 2 C.A.KIRBY,T.STAMS,N.J.WATERS,W.SHAOTITL STRUCTURE-EFFICIENCY RELATIONSHIP OFTITL 2 [1,2,4]TRIAZOL-3-YLAMINES AS NOVEL NICOTINAMIDE ISOSTERESTITL 3 THAT INHIBIT TANKYRASES.REF J.MED.CHEM. V. 56 7049 2013REFN ISSN 0022-2623PMID 23879431DOI 10.1021/JM400826J

Variant Set Distributions

ExAC Variants

Number Of Residues 204
Number Of SNVs 41
Number Of Permutations 15253
Optimal Distance Threshold 13.0
K Statistic 0.129
p-value 0.143

Mapped Variants

[+] ExAC Missense Variants