Assessment of Structural Intolerance and Durability
General Structure Information 2a9j BPGM human bisphosphoglycerate mutase complexed with 3- phosphoglycerate (17 days) 2.0Å AUTH Y.WANG,L.LIU,Z.WEI,Z.CHENG,Y.LIN,W.GONGTITL SEEING THE PROCESS OF HISTIDINE PHOSPHORYLATION INTITL 2 HUMAN BISPHOSPHOGLYCERATE MUTASEREF J.BIOL.CHEM. V. 281 39642 2006REFN ISSN 0021-9258PMID 17052986DOI 10.1074/JBC.M606421200 Variant Set Distributions Mapped Variants
General Structure Information 3ewu UMPS d312n mutant of human orotidyl-5-monophosphate decarboxylase in complex with 6-acetyl-ump, covalent adduct 1.6Å AUTH D.HEINRICH,U.DIEDERICHSEN,M.G.RUDOLPHTITL LYS314 IS A NUCLEOPHILE IN NON-CLASSICAL REACTIONS OFTITL 2 OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASEREF CHEMISTRY V. 15 6619 2009REFN ISSN 0947-6539PMID 19472232DOI 10.1002/CHEM.200900397 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fht SNRPA rna-binding domain of the u1a spliceosomal protein u1a117, nmr, 43 structures -1.0Å AUTH J.M.AVIS,F.H.ALLAIN,P.W.HOWE,G.VARANI,K.NAGAI,AUTH 2 D.NEUHAUSTITL SOLUTION STRUCTURE OF THE N-TERMINAL RNP DOMAIN OFTITL 2 U1A PROTEIN: THE ROLE OF C-TERMINAL RESIDUES INTITL 3 STRUCTURE STABILITY AND RNA BINDING.REF J.MOL.BIOL. V. 257 398 1996REFN ISSN 0022-2836PMID 8609632DOI 10.1006/JMBI.1996.0171 Variant Set […]
General Structure Information 2ebl NR2F1 solution structure of the zinc finger, c4-type domain of human coup transcription factor 1 -1.0Å AUTH M.YONEYAMA,S.KOSHIBA,S.WATABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZINC FINGER, C4-TYPETITL 2 DOMAIN OF HUMAN COUP TRANSCRIPTION FACTOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bqq PSAP crystal structure of human saposin d (triclinic) 2.0Å AUTH K.POPOVIC,G.G.PRIVETITL STRUCTURES OF THE HUMAN CERAMIDE ACTIVATOR PROTEINTITL 2 SAPOSIN D.REF ACTA CRYSTALLOGR.,SECT.D V. 64 589 2008REFN ISSN 0907-4449PMID 18453694DOI 10.1107/S0907444908003120 Variant Set Distributions Mapped Variants
General Structure Information 3ktv SRP19 crystal structure of the human srp19/s-domain srp rna complex 3.8Å AUTH K.WILD,G.BANGE,G.BOZKURT,B.SEGNITZ,A.HENDRICKS,I.SINNINGTITL STRUCTURAL INSIGHTS INTO THE ASSEMBLY OF THE HUMAN ANDTITL 2 ARCHAEAL SIGNAL RECOGNITION PARTICLES.REF ACTA CRYSTALLOGR.,SECT.D V. 66 295 2010REFN ISSN 0907-4449PMID 20179341DOI 10.1107/S0907444910000879 Variant Set Distributions Mapped Variants
General Structure Information 4elj RB1 crystal structure of the inactive retinoblastoma protein phosphorylated at t373 2.7Å AUTH J.R.BURKE,G.L.HURA,S.M.RUBINTITL STRUCTURES OF INACTIVE RETINOBLASTOMA PROTEIN REVEALTITL 2 MULTIPLE MECHANISMS FOR CELL CYCLE CONTROL.REF GENES DEV. V. 26 1156 2012REFN ISSN 0890-9369PMID 22569856DOI 10.1101/GAD.189837.112 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1rrj TOP1 structural mechanisms of camptothecin resistance by mutations in human topoisomerase i 2.3Å AUTH J.E.CHRENCIK,B.L.STAKER,A.B.BURGIN,P.POURQUIER,AUTH 2 Y.POMMIER,L.STEWART,M.R.REDINBOTITL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY HUMANTITL 2 TOPOISOMERASE I MUTATIONSREF J.MOL.BIOL. V. 339 773 2004REFN ISSN 0022-2836PMID 15165849DOI 10.1016/J.JMB.2004.03.077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4k87 EPRS crystal structure of human prolyl-trna synthetase (substrate bound form) 2.3Å AUTH J.SON,E.H.LEE,M.PARK,J.H.KIM,J.KIM,S.KIM,Y.H.JEON,K.Y.HWANGTITL CONFORMATIONAL CHANGES IN HUMAN PROLYL-TRNA SYNTHETASE UPONTITL 2 BINDING OF THE SUBSTRATES PROLINE AND ATP AND THE INHIBITORTITL 3 HALOFUGINONEREF ACTA CRYSTALLOGR.,SECT.D V. 69 2136 2013REFN ISSN 0907-4449DOI 10.1107/S0907444913020556 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3r01 PIM1 the discovery of novel benzofuran-2-carboxylic acids as potent pim-1 inhibitors 2.6Å AUTH Y.XIANG,B.HIRTH,G.ASMUSSEN,H.P.BIEMANN,K.A.BISHOP,A.GOOD,AUTH 2 M.FITZGERALD,T.GLADYSHEVA,A.JAIN,K.JANCSICS,J.LIU,M.METZ,AUTH 3 A.PAPOULIS,R.SKERLJ,J.D.STEPP,R.R.WEITITL THE DISCOVERY OF NOVEL BENZOFURAN-2-CARBOXYLIC ACIDS ASTITL 2 POTENT PIM-1 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 21 3050 2011REFN ISSN 0960-894XPMID 21507633DOI 10.1016/J.BMCL.2011.03.030 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants