Assessment of Structural Intolerance and Durability
General Structure Information 1l2z CD2 cd2bp2-gyf domain in complex with proline-rich cd2 tail segment peptide -1.0Å AUTH C.FREUND,R.KUHNE,H.YANG,S.PARK,E.L.REINHERZ,AUTH 2 G.WAGNERTITL DYNAMIC INTERACTION OF CD2 WITH THE GYF AND THETITL 2 SH3 DOMAIN OF COMPARTMENTALIZED EFFECTOR MOLECULESREF EMBO J. V. 21 5985 2002REFN ISSN 0261-4189PMID 12426371DOI 10.1093/EMBOJ/CDF602 Variant Set Distributions Mapped Variants
General Structure Information 2gco RHOC crystal structure of the human rhoc-gppnhp complex 1.4Å AUTH S.M.G.DIAS,R.A.CERIONETITL X-RAY CRYSTAL STRUCTURES REVEAL TWO ACTIVATED STATES FORTITL 2 RHOC.REF BIOCHEMISTRY V. 46 6547 2007REFN ISSN 0006-2960PMID 17497936DOI 10.1021/BI700035P Variant Set Distributions Mapped Variants
General Structure Information 3gw3 UROD human urod mutant k297n 1.7Å AUTH C.A.WARBY,J.D.PHILLIPS,H.A.BERGONIA,F.G.WHITBY,C.P.HILL,AUTH 2 J.P.KUSHNERTITL STRUCTURAL AND KINETIC CHARACTERIZATION OF MUTANT HUMANTITL 2 UROPORPHYRINOGEN DECARBOXYLASES.REF CELL MOL BIOL V. 55 40 2009REF 2 (NOISY-LE-GRAND)REFNPMID 19656450 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fze ADH5 crystal structure of the binary complex of human glutathione-dependent formaldehyde dehydrogenase with adp- ribose 1.9Å AUTH P.C.SANGHANI,W.I.DAVIS,L.ZHAI,H.ROBINSONTITL STRUCTURE-FUNCTION RELATIONSHIPS IN HUMANTITL 2 GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROGENASE.TITL 3 ROLE OF GLU-67 AND ARG-368 IN THE CATALYTICTITL 4 MECHANISM.REF BIOCHEMISTRY V. 45 4819 2006REFN ISSN 0006-2960PMID 16605250DOI 10.1021/BI052554Q Variant Set Distributions Ripley’s K […]
General Structure Information 3cw1 SNRNP70 crystal structure of human spliceosomal u1 snrnp 5.49Å AUTH D.A.POMERANZ KRUMMEL,C.OUBRIDGE,A.K.LEUNG,J.LI,K.NAGAITITL CRYSTAL STRUCTURE OF HUMAN SPLICEOSOMAL U1 SNRNP AT 5.5 ATITL 2 RESOLUTION.REF NATURE V. 458 475 2009REFN ISSN 0028-0836PMID 19325628DOI 10.1038/NATURE07851 Variant Set Distributions Mapped Variants
General Structure Information 2yrq HMGB1 solution structure of the tandem hmg box domain from human high mobility group protein b1 -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE TANDEM HMG BOX DOMAINTITL 2 FROM HUMAN HIGH MOBILITY GROUP PROTEIN B1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ojy C8B crystal structure of human complement component c8 2.51Å AUTH L.L.LOVELACE,C.L.COOPER,J.M.SODETZ,L.LEBIODATITL STRUCTURE OF HUMAN C8 PROTEIN PROVIDES MECHANISTIC INSIGHTTITL 2 INTO MEMBRANE PORE FORMATION BY COMPLEMENT.REF J.BIOL.CHEM. V. 286 17585 2011REFN ISSN 0021-9258PMID 21454577DOI 10.1074/JBC.M111.219766 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ojy C8A crystal structure of human complement component c8 2.51Å AUTH L.L.LOVELACE,C.L.COOPER,J.M.SODETZ,L.LEBIODATITL STRUCTURE OF HUMAN C8 PROTEIN PROVIDES MECHANISTIC INSIGHTTITL 2 INTO MEMBRANE PORE FORMATION BY COMPLEMENT.REF J.BIOL.CHEM. V. 286 17585 2011REFN ISSN 0021-9258PMID 21454577DOI 10.1074/JBC.M111.219766 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zcm CAPN1 human calpain protease core inhibited by zllych2f 2.0Å AUTH Q.LI,R.P.HANZLIK,R.F.WEAVER,E.SCHONBRUNNTITL MOLECULAR MODE OF ACTION OF A COVALENTLYTITL 2 INHIBITING PEPTIDOMIMETIC ON THE HUMAN CALPAINTITL 3 PROTEASE COREREF BIOCHEMISTRY V. 45 701 2006REFN ISSN 0006-2960PMID 16411745DOI 10.1021/BI052077B Variant Set Distributions Mapped Variants
General Structure Information 1ijt FGF4 crystal structure of fibroblast growth factor 4 (fgf4) 1.8Å AUTH P.BELLOSTA,A.IWAHORI,A.N.PLOTNIKOV,A.V.ELISEENKOVA,AUTH 2 C.BASILICO,M.MOHAMMADITITL IDENTIFICATION OF RECEPTOR AND HEPARIN BINDINGTITL 2 SITES IN FIBROBLAST GROWTH FACTOR 4 BYTITL 3 STRUCTURE-BASED MUTAGENESIS.REF MOL.CELL.BIOL. V. 21 5946 2001REFN ISSN 0270-7306PMID 11486033DOI 10.1128/MCB.21.17.5946-5957.2001 Variant Set Distributions Mapped Variants