Assessment of Structural Intolerance and Durability
General Structure Information 3i2b PTS the crystal structure of human 6 pyruvoyl tetrahydrobiopterin synthase 2.3Å AUTH E.UGOCHUKWU,R.COCKING,E.PILKA,W.W.YUE,J.E.BRAY,A.CHAIKUAD,AUTH 2 T.KROJER,J.MUNIZ,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN 6 PYRUVOYLTITL 2 TETRAHYDROBIOPTERIN SYNTHASEREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qsc TRAF2 crystal structure of the traf domain of traf2 in a complex with a peptide from the cd40 receptor 2.4Å AUTH S.M.MCWHIRTER,S.S.PULLEN,J.M.HOLTON,J.J.CRUTE,AUTH 2 M.R.KEHRY,T.ALBERTITL CRYSTALLOGRAPHIC ANALYSIS OF CD40 RECOGNITION ANDTITL 2 SIGNALING BY HUMAN TRAF2.REF PROC.NATL.ACAD.SCI.USA V. 96 8408 1999REFN ISSN 0027-8424PMID 10411888DOI 10.1073/PNAS.96.15.8408 Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2j5d BNIP3 nmr structure of bnip3 transmembrane domain in lipid bicelles -1.0Å AUTH E.V.BOCHAROV,Y.E.PUSTOVALOVA,K.V.PAVLOV,AUTH 2 P.E.VOLYNSKY,M.V.GONCHARUK,Y.S.ERMOLYUK,AUTH 3 D.V.KARPUNIN,A.A.SCHULGA,M.P.KIRPICHNIKOV,AUTH 4 R.G.EFREMOV,I.V.MASLENNIKOV,A.S.ARSENIEVTITL UNIQUE DIMERIC STRUCTURE OF BNIP3 TRANSMEMBRANETITL 2 DOMAIN SUGGESTS MEMBRANE PERMEABILIZATION AS ATITL 3 CELL DEATH TRIGGER.REF J.BIOL.CHEM. V. 282 16256 2007REFN ISSN 0021-9258PMID 17412696DOI 10.1074/JBC.M701745200 Variant Set Distributions Mapped Variants
General Structure Information 2j2s KMT2A solution structure of the nonmethyl-cpg-binding cxxc domain of the leukaemia-associated mll histone methyltransferase -1.0Å AUTH M.D.ALLEN,C.G.GRUMMITT,C.HILCENKO,S.Y.MIN,AUTH 2 L.M.TONKIN,C.M.JOHNSON,S.M.FREUND,M.BYCROFT,AUTH 3 A.J.WARRENTITL SOLUTION STRUCTURE OF THE NONMETHYL-CPG-BINDINGTITL 2 CXXC DOMAIN OF THE LEUKAEMIA-ASSOCIATED MLLTITL 3 HISTONE METHYLTRANSFERASEREF EMBO J. V. 25 4503 2006REFN ISSN 0261-4189PMID 16990798DOI 10.1038/SJ.EMBOJ.7601340 Variant Set Distributions Mapped Variants
General Structure Information 1ljm RUNX1 dna recognition is mediated by conformational transition and by dna bending 2.5Å AUTH D.BARTFELD,L.SHIMON,G.COUTURE,D.RABINOVICH,AUTH 2 F.FROLOW,D.LEVANON,Y.GRONER,Z.SHAKKEDTITL DNA RECOGNITION BY THE RUNX1 TRANSCRIPTION FACTORTITL 2 IS MEDIATED BY AN ALLOSTERIC TRANSITION IN THETITL 3 RUNT DOMAIN AND BY DNA BENDING.REF STRUCTURE V. 10 1395REFN ISSN 0969-2126PMID 12377125DOI 10.1016/S0969-2126(02)00853-5 Variant Set Distributions […]
General Structure Information 3wiy MCL1 crystal structure of mcl-1 in complex with compound 10 2.15Å AUTH Y.TANAKA,K.AIKAWA,G.NISHIDA,M.HOMMA,S.SOGABE,S.IGAKI,AUTH 2 Y.HAYANO,T.SAMESHIMA,I.MIYAHISA,T.KAWAMOTO,M.TAWADA,Y.IMAI,AUTH 3 M.INAZUKA,N.CHO,Y.IMAEDA,T.ISHIKAWATITL DISCOVERY OF POTENT MCL-1/BCL-XL DUAL INHIBITORS BY USING ATITL 2 HYBRIDIZATION STRATEGY BASED ON STRUCTURAL ANALYSIS OFTITL 3 TARGET PROTEINS.REF J.MED.CHEM. V. 56 9635 2013REFN ISSN 0022-2623PMID 24215352DOI 10.1021/JM401170C Variant Set Distributions Mapped Variants
General Structure Information 3jui EIF2B5 crystal structure of the c-terminal domain of human translation initiation factor eif2b epsilon subunit 2.0Å AUTH J.WEI,H.XU,C.ZHANG,M.WANG,F.GAO,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMANTITL 2 TRANSLATION INITIATION FACTOR EIF2B EPSILON SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants