Assessment of Structural Intolerance and Durability
General Structure Information 2lc3 HECTD1 solution nmr structure of a helical bundle domain from human e3 ligase hectd1. northeast structural genomics consortium (nesg) target ht6305a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,C.ARROWSMITH,AUTH 2 S.DHE-PAGANONTITL NMR SOLUTION STRUCTURE OF A HELICAL BUNDLE FROM THE E3TITL 2 LIGASE HECTD1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qtl MTRR crystal structure of the fad-containing fnr-like module of human methionine synthase reductase 1.9Å AUTH K.R.WOLTHERS,X.LOU,H.S.TOOGOOD,D.LEYS,N.S.SCRUTTONTITL MECHANISM OF COENZYME BINDING TO HUMAN METHIONINE SYNTHASETITL 2 REDUCTASE REVEALED THROUGH THE CRYSTAL STRUCTURE OF THETITL 3 FNR-LIKE MODULE AND ISOTHERMAL TITRATION CALORIMETRYREF BIOCHEMISTRY V. 46 11833 2007REFN ISSN 0006-2960PMID 17892308DOI 10.1021/BI701209P Variant Set […]
General Structure Information 2ee3 COL20A1 solution structures of the fn3 domain of human collagen alpha-1(xx) chain -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE FN3 DOMAIN OF HUMANTITL 2 COLLAGEN ALPHA-1(XX) CHAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4i6j FBXL3 a ubiquitin ligase-substrate complex 2.7Å AUTH W.XING,L.BUSINO,T.R.HINDS,S.T.MARIONNI,N.H.SAIFEE,M.F.BUSH,AUTH 2 M.PAGANO,N.ZHENGTITL SCFFBXL3 UBIQUITIN LIGASE TARGETS CRYPTOCHROMES AT THEIRTITL 2 COFACTOR POCKET.REF NATURE V. 496 64 2013REFN ISSN 0028-0836PMID 23503662DOI 10.1038/NATURE11964 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dzj TECR 2dzj/solution structure of the n-terminal ubiquitin-like domain in human synaptic glycoprotein sc2 -1.0Å AUTH C.ZHAO,M.YONEYAMA,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL 2DZJ/SOLUTION STRUCTURE OF THE N-TERMINALTITL 2 UBIQUITIN-LIKE DOMAIN IN HUMAN SYNAPTICTITL 3 GLYCOPROTEIN SC2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3aca NUDT5 crystal structure of human nudt5 complexed with 8-oxo-dadp and manganese 2.05Å AUTH T.ARIMORI,H.TAMAOKI,T.NAKAMURA,H.KAMIYA,S.IKEMIZU,Y.TAKAGI,AUTH 2 T.ISHIBASHI,H.HARASHIMA,M.SEKIGUCHI,Y.YAMAGATATITL DIVERSE SUBSTRATE RECOGNITION AND HYDROLYSIS MECHANISMS OFTITL 2 HUMAN NUDT5REF NUCLEIC ACIDS RES. V. 39 8972 2011REFN ISSN 0305-1048PMID 21768126DOI 10.1093/NAR/GKR575 Variant Set Distributions Mapped Variants
General Structure Information 1y8r UBA2 sumo e1 activating enzyme sae1-sae2-sumo1-mg-atp complex 2.75Å AUTH L.M.LOIS,C.D.LIMATITL STRUCTURES OF THE SUMO E1 PROVIDE MECHANISTICTITL 2 INSIGHTS INTO SUMO ACTIVATION AND E2 RECRUITMENTTITL 3 TO E1REF EMBO J. V. 24 439 2005REFN ISSN 0261-4189PMID 15660128DOI 10.1038/SJ.EMBOJ.7600552 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1y8r SAE1 sumo e1 activating enzyme sae1-sae2-sumo1-mg-atp complex 2.75Å AUTH L.M.LOIS,C.D.LIMATITL STRUCTURES OF THE SUMO E1 PROVIDE MECHANISTICTITL 2 INSIGHTS INTO SUMO ACTIVATION AND E2 RECRUITMENTTITL 3 TO E1REF EMBO J. V. 24 439 2005REFN ISSN 0261-4189PMID 15660128DOI 10.1038/SJ.EMBOJ.7600552 Variant Set Distributions Mapped Variants
General Structure Information 4afl ING4 the crystal structure of the ing4 dimerization domain reveals the functional organization of the ing family of chromatin binding proteins. 2.28Å AUTH S.CULURGIONI,I.G.MUNOZ,A.MORENO,A.PALACIOS,M.VILLATE,AUTH 2 I.PALMERO,G.MONTOYA,F.J.BLANCOTITL CRYSTAL STRUCTURE OF INHIBITOR OF GROWTH 4 (ING4)TITL 2 DIMERIZATION DOMAIN REVEALS FUNCTIONAL ORGANIZATION OF INGTITL 3 FAMILY OF CHROMATIN-BINDING PROTEINS.REF J.BIOL.CHEM. V. 287 10876 […]
General Structure Information 2boa CPA4 human procarboxypeptidase a4. 2.2Å AUTH R.GARCIA-CASTELLANOS,R.BONET-FIGUEREDO,I.PALLARES,AUTH 2 S.VENTURA,F.X.AVILES,J.VENDRELL,F.X.GOMIS-RUTHTITL DETAILED MOLECULAR COMPARISON BETWEEN THETITL 2 INHIBITION MODE OF A/B-TYPE CARBOXYPEPTIDASES INTITL 3 THE ZYMOGEN STATE AND BY THE ENDOGENOUS INHIBITORTITL 4 LATEXIN.REF CELL.MOL.LIFE SCI. V. 62 1996 2005REFN ISSN 1420-682XPMID 16091843DOI 10.1007/S00018-005-5174-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]