Assessment of Structural Intolerance and Durability
General Structure Information 3t6g SH2D3C structure of the complex between nsp3 (shep1) and p130cas 2.5Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Mapped Variants
General Structure Information 2ypa LDB1 structure of the scl:e47:lmo2:ldb1 complex bound to dna 2.8Å AUTH K.EL OMARI,S.J.HOOSDALLY,K.TULADHAR,D.KARIA,E.HALL-PONSELE,AUTH 2 O.PLATONOVA,P.VYAS,R.PATIENT,C.PORCHER,E.J.MANCINITITL STRUCTURAL BASIS FOR LMO2-DRIVEN RECRUITMENT OF THETITL 2 SCL:E47BHLH HETERODIMER TO HEMATOPOIETIC-SPECIFICTITL 3 TRANSCRIPTIONAL TARGETS.REF CELL REP. V. 4 135 2013REFN ISSN 2211-1247PMID 23831025DOI 10.1016/J.CELREP.2013.06.008 Variant Set Distributions Mapped Variants
General Structure Information 4nf9 CASC5 structure of the knl1/nsl1 complex 2.8Å AUTH A.PETROVIC,S.MOSALAGANTI,J.KELLER,M.MATTIUZZO,K.OVERLACK,AUTH 2 V.KRENN,A.DE ANTONI,S.WOHLGEMUTH,V.CECATIELLO,S.PASQUALATO,AUTH 3 S.RAUNSER,A.MUSACCHIOTITL MODULAR ASSEMBLY OF RWD DOMAINS ON THE MIS12 COMPLEXTITL 2 UNDERLIES OUTER KINETOCHORE ORGANIZATION.REF MOL.CELL V. 53 591 2014REFN ISSN 1097-2765PMID 24530301DOI 10.1016/J.MOLCEL.2014.01.019 Variant Set Distributions Mapped Variants
General Structure Information 4fp9 MTERFD2 human mterf4-nsun4 protein complex 2.9Å AUTH H.SPAHR,B.HABERMANN,C.M.GUSTAFSSON,N.G.LARSSON,B.M.HALLBERGTITL STRUCTURE OF THE HUMAN MTERF4-NSUN4 PROTEIN COMPLEX THATTITL 2 REGULATES MITOCHONDRIAL RIBOSOME BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 109 15253 2012REFN ISSN 0027-8424PMID 22949673DOI 10.1073/PNAS.1210688109 Variant Set Distributions Mapped Variants
General Structure Information 2m5v NLRP10 three-dimensional structure of human nlrp10/pynod pyrin domain -1.0Å AUTH M.Y.SU,C.I.KUO,C.F.CHANG,C.I.CHANGTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN NLRP10/PYNOD PYRINTITL 2 DOMAIN REVEALS A HOMOTYPIC INTERACTION SITE DISTINCT FROMTITL 3 ITS MOUSE HOMOLOGUE.REF PLOS ONE V. 8 67843 2013REFN ESSN 1932-6203PMID 23861819DOI 10.1371/JOURNAL.PONE.0067843 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3p2t LILRB4 crystal structure of leukocyte ig-like receptor lilrb4 (ilt3/lir- 5/cd85k) 1.7Å AUTH H.CHENG,F.MOHAMMED,G.NAM,Y.CHEN,J.QI,L.I.GARNER,R.L.ALLEN,AUTH 2 J.YAN,B.E.WILLCOX,G.F.GAOTITL CRYSTAL STRUCTURE OF LEUKOCYTE IG-LIKE RECEPTOR LILRB4TITL 2 (ILT3/LIR-5/CD85K): A MYELOID INHIBITORY RECEPTOR INVOLVEDTITL 3 IN IMMUNE TOLERANCEREF J.BIOL.CHEM. V. 286 18013 2011REFN ISSN 0021-9258PMID 21454581DOI 10.1074/JBC.M111.221028 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2rgn ARHGEF25 crystal structure of p63rhogef complex with galpha-q and rhoa 3.5Å AUTH S.LUTZ,A.SHANKARANARAYANAN,C.COCO,M.RIDILLA,M.R.NANCE,AUTH 2 C.VETTEL,D.BALTUS,C.R.EVELYN,R.R.NEUBIG,T.WIELAND,J.J.TESMERTITL STRUCTURE OF GALPHAQ-P63RHOGEF-RHOA COMPLEX REVEALS ATITL 2 PATHWAY FOR THE ACTIVATION OF RHOA BY GPCRS.REF SCIENCE V. 318 1923 2007REFN ISSN 0036-8075PMID 18096806DOI 10.1126/SCIENCE.1147554 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4lla LILRB2 crystal structure of d3d4 domain of the lilrb2 molecule 2.5Å AUTH G.NAM,Y.SHI,M.RYU,Q.WANG,H.SONG,J.LIU,J.YAN,J.QI,G.F.GAOTITL CRYSTAL STRUCTURES OF THE TWO MEMBRANE-PROXIMAL IG-LIKETITL 2 DOMAINS (D3D4) OF LILRB1/B2: ALTERNATIVE MODELS FOR THEIRTITL 3 INVOLVEMENT IN PEPTIDE-HLA BINDINGREF PROTEIN CELL V. 4 761 2013REFN ISSN 1674-800XPMID 23955630DOI 10.1007/S13238-013-3908-X Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4ll9 LILRB1 crystal structure of d3d4 domain of the lilrb1 molecule 2.69Å AUTH G.NAM,Y.SHI,M.RYU,Q.WANG,H.SONG,J.LIU,J.YAN,J.QI,G.F.GAOTITL CRYSTAL STRUCTURES OF THE TWO MEMBRANE-PROXIMAL IG-LIKETITL 2 DOMAINS (D3D4) OF LILRB1/B2: ALTERNATIVE MODELS FOR THEIRTITL 3 INVOLVEMENT IN PEPTIDE-HLA BINDINGREF PROTEIN CELL V. 4 761 2013REFN ISSN 1674-800XPMID 23955630DOI 10.1007/S13238-013-3908-X Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3t30 NPM2 human nucleoplasmin (npm2): a histone chaperone in oocytes and early embryos 1.9Å AUTH O.PLATONOVA,I.V.AKEY,J.F.HEAD,C.W.AKEYTITL CRYSTAL STRUCTURE AND FUNCTION OF HUMAN NUCLEOPLASMINTITL 2 (NPM2): A HISTONE CHAPERONE IN OOCYTES AND EMBRYOS.REF BIOCHEMISTRY V. 50 8078 2011REFN ISSN 0006-2960PMID 21863821DOI 10.1021/BI2006652 Variant Set Distributions Mapped Variants