Assessment of Structural Intolerance and Durability
General Structure Information 2ar5 PIK3C2A crystal structure of the mammalian c2alpha-pi3 kinase px-domain 1.8Å AUTH G.N.PARKINSON,D.VINES,P.C.DRISCOLL,S.DJORDJEVICTITL LIGAND-BINDING SPECIFICITY OF PI3KINASE C2ALPHA PX DOMAIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2w2i KDM4E crystal structure of the human 2-oxoglutarate oxygenase loc390245 2.1Å AUTH L.HILLRINGHAUS,W.W.YUE,N.R.ROSE,S.S.NG,C.GILEADI,C.LOENARZ,AUTH 2 S.H.BELLO,J.E.BRAY,C.J.SCHOFIELD,U.OPPERMANNTITL STRUCTURAL AND EVOLUTIONARY BASIS FOR THE DUAL SUBSTRATETITL 2 SELECTIVITY OF HUMAN KDM4 HISTONE DEMETHYLASE FAMILY.REF J.BIOL.CHEM. V. 286 41616 2011REFN ISSN 0021-9258PMID 21914792DOI 10.1074/JBC.M111.283689 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3q6o QSOX1 oxidoreductase fragment of human qsox1 2.05Å AUTH A.ALON,I.GROSSMAN,Y.GAT,V.K.KODALI,F.DIMAIO,T.MEHLMAN,AUTH 2 G.HARAN,D.BAKER,C.THORPE,D.FASSTITL THE DYNAMIC DISULPHIDE RELAY OF QUIESCIN SULPHYDRYL OXIDASE.REF NATURE V. 488 414 2012REFN ISSN 0028-0836PMID 22801504DOI 10.1038/NATURE11267 Variant Set Distributions Mapped Variants
General Structure Information 1nun FGF10 crystal structure analysis of the fgf10-fgfr2b complex 2.9Å AUTH B.K.YEH,M.IGARASHI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,AUTH 2 I.SHER,D.RON,S.A.AARONSON,M.MOHAMMADITITL STRUCTURAL BASIS BY WHICH ALTERNATIVE SPLICINGTITL 2 CONFERS SPECIFICITY IN FIBROBLAST GROWTH FACTORTITL 3 RECEPTORS.REF PROC.NATL.ACAD.SCI.USA V. 100 2266 2003REFN ISSN 0027-8424PMID 12591959DOI 10.1073/PNAS.0436500100 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2wim NCAM2 crystal structure of ncam2 ig1-3 3.0Å AUTH N.KULAHIN,O.KRISTENSEN,K.K.RASMUSSEN,L.OLSEN,P.RYDBERG,AUTH 2 B.VESTERGAARD,J.S.KASTRUP,V.BEREZIN,E.BOCK,P.S.WALMOD,AUTH 3 M.GAJHEDETITL STRUCTURAL MODEL AND TRANS-INTERACTION OF THE ENTIRETITL 2 ECTODOMAIN OF THE OLFACTORY CELL ADHESION MOLECULE.REF STRUCTURE V. 19 203 2011REFN ISSN 0969-2126PMID 21300289DOI 10.1016/J.STR.2010.12.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3rn5 AIM2 structural basis of cytosolic dna recognition by innate immune receptors 2.5Å AUTH T.JIN,A.PERRY,J.JIANG,P.SMITH,J.A.CURRY,L.UNTERHOLZNER,AUTH 2 Z.JIANG,G.HORVATH,V.A.RATHINAM,R.W.JOHNSTONE,V.HORNUNG,AUTH 3 E.LATZ,A.G.BOWIE,K.A.FITZGERALD,T.S.XIAOTITL STRUCTURES OF THE HIN DOMAIN:DNA COMPLEXES REVEAL LIGANDTITL 2 BINDING AND ACTIVATION MECHANISMS OF THE AIM2 INFLAMMASOMETITL 3 AND IFI16 RECEPTOR.REF IMMUNITY V. 36 561 2012REFN ISSN 1074-7613PMID 22483801DOI 10.1016/J.IMMUNI.2012.02.014 Variant Set Distributions […]
General Structure Information 2jll NCAM2 crystal structure of ncam2 igiv-fn3ii 2.3Å AUTH N.KULAHIN,O.KRISTENSEN,K.K.RASMUSSEN,L.OLSEN,P.RYDBERG,AUTH 2 B.VESTERGAARD,J.S.KASTRUP,V.BEREZIN,E.BOCK,P.S.WALMOD,AUTH 3 M.GAJHEDETITL STRUCTURAL MODEL AND TRANS-INTERACTION OF THE ENTIRETITL 2 ECTODOMAIN OF THE OLFACTORY CELL ADHESION MOLECULE.REF STRUCTURE V. 19 203 2011REFN ISSN 0969-2126PMID 21300289DOI 10.1016/J.STR.2010.12.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4kax CYTH3 crystal structure of the grp1 ph domain in complex with arf6-gtp 1.85Å AUTH A.W.MALABY,B.VAN DEN BERG,D.G.LAMBRIGHTTITL STRUCTURAL BASIS FOR MEMBRANE RECRUITMENT AND ALLOSTERICTITL 2 ACTIVATION OF CYTOHESIN FAMILY ARF GTPASE EXCHANGE FACTORS.REF PROC.NATL.ACAD.SCI.USA V. 110 14213 2013REFN ISSN 0027-8424PMID 23940353DOI 10.1073/PNAS.1301883110 Variant Set Distributions Mapped Variants
General Structure Information 2xik STK25 structure of human ysk1 (yeast sps1-ste20-related kinase 1) 1.97Å AUTH J.R.C.MUNIZ,P.RELLOS,M.VOLLMAR,C.ALLERSTON,A.CHAIKUAD,AUTH 2 P.SAVITSKY,G.BERRIDGE,B.BRENNER,J.M.ELKINS,N.DAGA,O.GILEADI,AUTH 3 P.MAHAJAN,B.SHRESTHA,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 4 J.WEIGELT,C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN YSK1 (YEAST SPS1-STE20-RELATED KINASE 1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ekp BCAT2 crystal structure of human branched chain amino acid aminotransferase (mitochondrial) complexed with pyridoxal-5-phosphate at 2.5 angstroms (monoclinic form). 2.5Å AUTH N.YENNAWAR,J.DUNBAR,M.CONWAY,S.HUTSON,G.FARBERTITL THE STRUCTURE OF HUMAN MITOCHONDRIAL BRANCHED-CHAINTITL 2 AMINOTRANSFERASE.REF ACTA CRYSTALLOGR.,SECT.D V. 57 506 2001REFN ISSN 0907-4449PMID 11264579DOI 10.1107/S0907444901001925 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]