Assessment of Structural Intolerance and Durability
General Structure Information 2dk7 TCERG1 solution structure of ww domain in transcription elongation regulator 1 -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF WW DOMAIN IN TRANSCRIPTIONTITL 2 ELONGATION REGULATOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1x2l CUX2 solution structure of the cut domain of human homeobox protein cux-2 (cut-like 2) -1.0Å AUTH Y.O.KAMATARI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CUT DOMAIN OF HUMANTITL 2 HOMEOBOX PROTEIN CUX-2 (CUT-LIKE 2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2k4p INPPL1 solution structure of ship2-sam -1.0Å AUTH M.LEONE,J.CELLITTI,M.PELLECCHIATITL NMR STUDIES OF A HETEROTYPIC SAM-SAM DOMAINTITL 2 ASSOCIATION: THE INTERACTION BETWEEN THE LIPIDTITL 3 PHOSPHATASE SHIP2 AND THE EPHA2 RECEPTOR.REF BIOCHEMISTRY V. 47 12721 2008REFN ISSN 0006-2960PMID 18991394DOI 10.1021/BI801713F Variant Set Distributions Mapped Variants
General Structure Information 4j8s CNOT1 crystal structure of human cnot1 mif4g domain in complex with a ttp peptide 1.55Å AUTH M.R.FABIAN,F.FRANK,C.ROUYA,N.SIDDIQUI,W.S.LAI,A.KARETNIKOV,AUTH 2 P.J.BLACKSHEAR,B.NAGAR,N.SONENBERGTITL STRUCTURAL BASIS FOR THE RECRUITMENT OF THE HUMAN CCR4-NOTTITL 2 DEADENYLASE COMPLEX BY TRISTETRAPROLIN.REF NAT.STRUCT.MOL.BIOL. V. 20 735 2013REFN ISSN 1545-9993PMID 23644599DOI 10.1038/NSMB.2572 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2jju SIRPB1 structure of human signal regulatory protein (sirp) beta 1.19Å AUTH D.HATHERLEY,S.C.GRAHAM,J.TURNER,K.HARLOS,AUTH 2 D.I.STUART,A.N.BARCLAYTITL PAIRED RECEPTOR SPECIFICITY EXPLAINED BYTITL 2 STRUCTURES OF SIGNAL REGULATORY PROTEINS ALONE ANDTITL 3 COMPLEXED WITH CD47.REF MOL.CELL V. 31 266 2008REFN ISSN 1097-2765PMID 18657508DOI 10.1016/J.MOLCEL.2008.05.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2f7s RAB27B the crystal structure of human rab27b bound to gdp 2.7Å AUTH J.WANG,S.ISMAIL,Y.SHEN,W.TEMPEL,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,A.BOCHKAREV,H.W.PARKTITL THE CRYSTAL STRUCTURE OF HUMAN RAB27BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1z3k NCK2 structural insight into the binding diversity between the tyr-phosphorylated human ephrinbs and nck2 sh2 domain -1.0Å AUTH X.RAN,J.SONGTITL STRUCTURAL INSIGHT INTO THE BINDING DIVERSITYTITL 2 BETWEEN THE TYR-PHOSPHORYLATED HUMAN EPHRINBS ANDTITL 3 NCK2 SH2 DOMAIN.REF J.BIOL.CHEM. V. 280 19205 2005REFN ISSN 0021-9258PMID 15764601DOI 10.1074/JBC.M500330200 Variant Set Distributions Mapped Variants
General Structure Information 2fim TULP1 structure of the c-terminal domain of human tubby-like protein 1 1.9Å AUTH C.PERSSON,D.OGG,A.G.THORSELL,C.ARROWSMITH,H.BERGLUND,AUTH 2 A.EDWARDS,M.EHN,S.FLODIN,S.GRASLUND,M.HAMMARSTROM,M.HOGBOM,AUTH 3 L.HOLMBERG-SCHIAVONE,T.KOTENYOVA,P.KURSULA,P.NILSSON-EHLE,AUTH 4 P.NORDLUND,T.NYMAN,J.SAGEMARK,P.STENMARK,M.SUNDSTROM,AUTH 5 S.VAN DEN BERG,J.WEIGELT,B.M.HALLBERGTITL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN TUBBY-LIKETITL 2 PROTEIN 1REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ihb RGS10 crystal structure of the heterodimeric complex of human rgs10 and activated gi alpha 3 2.71Å AUTH M.SOUNDARARAJAN,F.S.WILLARD,A.J.KIMPLE,A.P.TURNBULL,AUTH 2 L.J.BALL,G.A.SCHOCH,C.GILEADI,O.Y.FEDOROV,E.F.DOWLER,AUTH 3 V.A.HIGMAN,S.Q.HUTSELL,M.SUNDSTROM,D.A.DOYLE,D.P.SIDEROVSKITITL STRUCTURAL DIVERSITY IN THE RGS DOMAIN AND ITS INTERACTIONTITL 2 WITH HETEROTRIMERIC G PROTEIN ALPHA-SUBUNITS.REF PROC.NATL.ACAD.SCI.USA V. 105 6457 2008REFN ISSN 0027-8424PMID 18434541DOI 10.1073/PNAS.0801508105 Variant Set Distributions Mapped Variants
General Structure Information 3hfh TCERG1 crystal structure of tandem ff domains 2.7Å AUTH M.LU,J.YANG,Z.REN,S.SABUI,A.ESPEJO,M.T.BEDFORD,AUTH 2 R.H.JACOBSON,D.JERUZALMI,J.S.MCMURRAY,X.CHENTITL CRYSTAL STRUCTURE OF THE THREE TANDEM FF DOMAINS OFTITL 2 THE TRANSCRIPTION ELONGATION REGULATOR CA150.REF J.MOL.BIOL. V. 393 397 2009REFN ISSN 0022-2836PMID 19660470DOI 10.1016/J.JMB.2009.07.086 Variant Set Distributions Mapped Variants