Assessment of Structural Intolerance and Durability
General Structure Information 3q3j PLXNA2 crystal structure of plexin a2 rbd in complex with rnd1 1.97Å AUTH H.WANG,W.TEMPEL,Y.TONG,X.GUAN,L.SHEN,L.BUREN,N.ZHANG,AUTH 2 A.K.WERNIMONT,L.CROMBET,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF PLEXIN A2 RBD IN COMPLEX WITH RND1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4e90 PDE9A human phosphodiesterase 9 in complex with inhibitors 2.5Å AUTH M.M.CLAFFEY,C.J.HELAL,P.R.VERHOEST,Z.KANG,K.S.FORS,S.JUNG,AUTH 2 J.ZHONG,M.W.BUNDESMANN,X.HOU,S.LUI,R.J.KLEIMAN,AUTH 3 M.VANASE-FRAWLEY,A.W.SCHMIDT,F.MENNITI,C.J.SCHMIDT,AUTH 4 W.E.HOFFMAN,M.HAJOS,L.MCDOWELL,R.E.OCONNOR,AUTH 5 M.MACDOUGALL-MURPHY,K.R.FONSECA,S.L.BECKER,F.R.NELSON,AUTH 6 S.LIRASTITL APPLICATION OF STRUCTURE-BASED DRUG DESIGN AND PARALLELTITL 2 CHEMISTRY TO IDENTIFY SELECTIVE, BRAIN PENETRANT, IN VIVOTITL 3 ACTIVE PHOSPHODIESTERASE 9A INHIBITORS.REF J.MED.CHEM. V. 55 9055 2012REFN ISSN 0022-2623PMID 23025719DOI 10.1021/JM3009635 […]
General Structure Information 2rpc ZIC3 solution structure of the tandem zf-c2h2 domains from the human zinc finger protein zic 3 -1.0Å AUTH M.HATAYAMA,T.TOMIZAWA,K.SAKAI-KATO,P.BOUVAGNET,AUTH 2 S.KOSE,N.IMAMOTO,S.YOKOYAMA,N.UTSUNOMIYA-TATE,AUTH 3 K.MIKOSHIBA,T.KIGAWA,J.ARUGATITL FUNCTIONAL AND STRUCTURAL BASIS OF THE NUCLEARTITL 2 LOCALIZATION SIGNAL IN THE ZIC3 ZINC FINGER DOMAINREF HUM.MOL.GENET. V. 17 3459 2008REFN ISSN 0964-6906PMID 18716025DOI 10.1093/HMG/DDN239 Variant Set Distributions […]
General Structure Information 1wh0 USP19 solution structure of the cs domain of human usp19 -1.0Å AUTH T.NAKANISHI,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CS DOMAIN OF HUMAN USP19REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cq0 EIF3G solution structure of rna binding domain in eukaryotic translation initiation factor 3 subunit 4 -1.0Å AUTH K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN INTITL 2 EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNITTITL 3 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1yo5 SPDEF analysis of the 2.0a crystal structure of the protein-dna complex of human pdef ets domain bound to the prostate specific antigen regulatory site 2.0Å AUTH Y.WANG,L.FENG,M.SAID,S.BALDERMAN,Z.FAYAZI,Y.LIU,AUTH 2 D.GHOSH,A.M.GULICKTITL ANALYSIS OF THE 2.0 A CRYSTAL STRUCTURE OF THETITL 2 PROTEIN-DNA COMPLEX OF THE HUMAN PDEF ETS DOMAINTITL 3 BOUND TO THE […]
General Structure Information 4ea4 MBD4 structure of the glycosylase domain of mbd4 bound to 5hmu-containing dna 2.0Å AUTH S.MORERA,I.GRIN,A.VIGOUROUX,S.COUVE,V.HENRIOT,M.SAPARBAEV,AUTH 2 A.A.ISHCHENKOTITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THETITL 2 GLYCOSYLASE DOMAIN OF MBD4 BOUND TO THYMINE ANDTITL 3 5-HYDROXYMETHYURACIL-CONTAINING DNA.REF NUCLEIC ACIDS RES. V. 40 9917 2012REFN ISSN 0305-1048PMID 22848106DOI 10.1093/NAR/GKS714 Variant Set Distributions Mapped Variants
General Structure Information 2z7x TLR2 crystal structure of the tlr1-tlr2 heterodimer induced by binding of a tri-acylated lipopeptide 2.1Å AUTH M.S.JIN,S.E.KIM,J.Y.HEO,M.E.LEE,H.M.KIM,S.G.PAIK,H.LEE,AUTH 2 J.O.LEETITL CRYSTAL STRUCTURE OF THE TLR1-TLR2 HETERODIMER INDUCED BYTITL 2 BINDING OF A TRI-ACYLATED LIPOPEPTIDEREF CELL(CAMBRIDGE,MASS.) V. 130 1071 2007REFN ISSN 0092-8674PMID 17889651DOI 10.1016/J.CELL.2007.09.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2nn2 ZBTB7A crystal structure of the btb domain from the lrf/zbtb7 transcriptional regulator 2.1Å AUTH P.J.STOGIOS,L.CHEN,G.G.PRIVETITL CRYSTAL STRUCTURE OF THE BTB DOMAIN FROM THETITL 2 LRF/ZBTB7 TRANSCRIPTIONAL REGULATOR.REF PROTEIN SCI. V. 16 336 2007REFN ISSN 0961-8368PMID 17189472DOI 10.1110/PS.062660907 Variant Set Distributions Mapped Variants
General Structure Information 3pt3 UBR5 crystal structure of the c-terminal lobe of the human ubr5 hect domain 1.97Å AUTH E.MATTA-CAMACHO,G.KOZLOV,M.MENADE,K.GEHRINGTITL STRUCTURE OF THE HECT C-LOBE OF THE UBR5 E3 UBIQUITINTITL 2 LIGASE.REF ACTA CRYSTALLOGR.,SECT.F V. 68 1158 2012REFN ESSN 1744-3091PMID 23027739DOI 10.1107/S1744309112036937 Variant Set Distributions Mapped Variants