General Structure Information
| PDB ID | 4e90 |
| HGNC Gene Label(s) | PDE9A |
| Structure Name | human phosphodiesterase 9 in complex with inhibitors |
| Resolution | 2.5Å |
| Reference | AUTH M.M.CLAFFEY,C.J.HELAL,P.R.VERHOEST,Z.KANG,K.S.FORS,S.JUNG,AUTH 2 J.ZHONG,M.W.BUNDESMANN,X.HOU,S.LUI,R.J.KLEIMAN,AUTH 3 M.VANASE-FRAWLEY,A.W.SCHMIDT,F.MENNITI,C.J.SCHMIDT,AUTH 4 W.E.HOFFMAN,M.HAJOS,L.MCDOWELL,R.E.OCONNOR,AUTH 5 M.MACDOUGALL-MURPHY,K.R.FONSECA,S.L.BECKER,F.R.NELSON,AUTH 6 S.LIRASTITL APPLICATION OF STRUCTURE-BASED DRUG DESIGN AND PARALLELTITL 2 CHEMISTRY TO IDENTIFY SELECTIVE, BRAIN PENETRANT, IN VIVOTITL 3 ACTIVE PHOSPHODIESTERASE 9A INHIBITORS.REF J.MED.CHEM. V. 55 9055 2012REFN ISSN 0022-2623PMID 23025719DOI 10.1021/JM3009635 |
Variant Set Distributions
ExAC Variants
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 76 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.215 |
| p-value | 0.325 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
