Assessment of Structural Intolerance and Durability
General Structure Information 3a03 TLX2 crystal structure of hox11l1 homeodomain 1.54Å AUTH K.MIYAZONO,Y.ZHI,Y.TAKAMURA,K.NAGATA,K.SAIGO,T.KOJIMA,AUTH 2 M.TANOKURATITL COOPERATIVE DNA-BINDING AND SEQUENCE-RECOGNITION MECHANISMTITL 2 OF ARISTALESS AND CLAWLESSREF EMBO J. V. 29 1613 2010REFN ISSN 0261-4189PMID 20389279DOI 10.1038/EMBOJ.2010.53 Variant Set Distributions Mapped Variants
General Structure Information 4lg7 MBD4 crystal structure mbd4 mbd domain in complex with methylated cpg dna 2.5Å AUTH C.XU,W.TEMPEL,A.K.WERNIMONT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,J.MINTITL CRYSTAL STRUCTURE MBD4 MBD DOMAIN IN COMPLEX WITH METHYLATEDTITL 2 CPG DNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2opg MPDZ the crystal structure of the 10th pdz domain of mpdz 1.5Å AUTH C.GILEADI,C.PHILLIPS,J.ELKINS,E.PAPAGRIGORIOU,AUTH 2 E.UGOCHUKWU,F.GORREC,P.SAVITSKY,C.UMEANO,AUTH 3 G.BERRIDGE,O.GILEADI,E.SALAH,A.EDWARDS,AUTH 4 C.H.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,D.A.DOYLE,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF THE 10TH PDZ DOMAIN OFTITL 2 MPDZREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1x3c ZNF292 solution structure of the c2h2 type zinc-binding domain of human zinc finger protein 292 -1.0Å AUTH M.YONEYAMA,T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC-BINDINGTITL 2 DOMAIN OF HUMAN ZINC FINGER PROTEIN 292REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2wwe PIK3C2G crystal structure of the phox homology domain of human phosphoinositide-3-kinase-c2-gamma 1.25Å AUTH A.K.ROOS,L.TRESAUGUES,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 A.KALLAS,T.KARLBERG,T.KOTYENOVA,A.KOTZCH,P.KRAULIS,AUTH 5 N.MARKOVA,M.MOCHE,T.K.NIELSEN,T.NYMAN,C.PERSSON,AUTH 6 H.SCHULER,P.SCHUTZ,M.I.SIPONEN,L.SVENSSON,AUTH 7 A.G.THORSELL,S.VAN DEN BERG,E.WAHLBERG,J.WEIGELT,AUTH 8 M.WELIN,M.WISNIEWSKA,P.NORDLUND,AUTH 9 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE PHOX HOMOLOGY DOMAIN OFTITL 2 HUMAN PHOSPHOINOSITIDE-3-KINASE-C2-GAMMAREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3ikk VAPB crystal structure analysis of msp domain 2.5Å AUTH J.SHI,S.LUA,J.S.TONG,J.SONGTITL ELIMINATION OF THE NATIVE STRUCTURE AND SOLUBILITY OF THETITL 2 HVAPB MSP DOMAIN BY THE PRO56SER MUTATION THAT CAUSESTITL 3 AMYOTROPHIC LATERAL SCLEROSIS.REF BIOCHEMISTRY V. 49 3887 2010REFN ISSN 0006-2960PMID 20377183DOI 10.1021/BI902057A Variant Set Distributions Mapped Variants
General Structure Information 4j2c STX6 garp-snare interaction 1.8Å AUTH G.ABASCAL-PALACIOS,C.SCHINDLER,A.L.ROJAS,J.S.BONIFACINO,AUTH 2 A.HIERROTITL STRUCTURAL BASIS FOR THE INTERACTION OF THE GOLGI-ASSOCIATEDTITL 2 RETROGRADE PROTEIN COMPLEX WITH THE T-SNARE SYNTAXIN 6.REF STRUCTURE V. 21 1698 2013REFN ISSN 0969-2126PMID 23932592DOI 10.1016/J.STR.2013.06.025 Variant Set Distributions Mapped Variants
General Structure Information 2diy GLRX3 the solution structure of the thioredoxin domain of human thioredoxin-like protein 2 -1.0Å AUTH N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE THIOREDOXIN DOMAINTITL 2 OF HUMAN THIOREDOXIN-LIKE PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1fyx TLR2 crystal structure of p681h mutant of tir domain of human tlr2 2.8Å AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2qkk RNASEH1 human rnase h catalytic domain mutant d210n in complex with 14-mer rna/dna hybrid 3.2Å AUTH M.NOWOTNY,S.A.GAIDAMAKOV,R.GHIRLANDO,AUTH 2 S.M.CERRITELLI,R.J.CROUCH,W.YANGTITL STRUCTURE OF HUMAN RNASE H1 COMPLEXED WITH ANTITL 2 RNA/DNA HYBRID: INSIGHT INTO HIV REVERSETITL 3 TRANSCRIPTIONREF MOL.CELL V. 28 264 2007REFN ISSN 1097-2765PMID 17964265DOI 10.1016/J.MOLCEL.2007.08.015 Variant Set Distributions Mapped Variants