Assessment of Structural Intolerance and Durability
General Structure Information 4ijd PRDM9 crystal structure of methyltransferase domain of human pr domain- containing protein 9 2.15Å AUTH L.DOMBROVSKI,A.DONG,Y.LI,W.TEMPEL,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,P.J.BROWN,H.WU,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN PRTITL 2 DOMAIN-CONTAINING PROTEIN 9REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2cmw CSNK1G1 structure of human casein kinase 1 gamma-1 in complex with 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9- isopropylpurine (casp target) 1.75Å AUTH G.BUNKOCZI,P.RELLOS,S.DAS,P.SAVITSKY,F.NIESEN,F.SOBOTT,AUTH 2 O.FEDOROV,A.C.W.PIKE,F.VON DELFT,M.SUNDSTROM,C.ARROWSMITH,AUTH 3 A.EDWARDS,J.WEIGELT,S.KNAPPTITL STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITHTITL 2 2-(2-HYDROXYETHYLAMINO)-6-TITL 3 (3-CHLOROANILINO)-9-ISOPROPYLPURINE (CASP TARGET)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3zdk DCLRE1B crystal structure of human 5 exonuclease apollo 2.16Å AUTH C.K.ALLERSTON,M.VOLLMAR,T.KROJER,A.C.W.PIKE,E.CARPENTER,AUTH 2 A.QUIGLEY,P.MAHAJAN,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 A.EDWARDS,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN 5 EXONUCLEASE APOLLOREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vhf CYLD structure of the cyld usp domain 2.8Å AUTH D.KOMANDER,C.J.LORD,H.SCHEEL,S.SWIFT,K.HOFMANN,AUTH 2 A.ASHWORTH,D.BARFORDTITL THE STRUCTURE OF THE CYLD USP DOMAIN EXPLAINS ITSTITL 2 SPECIFICITY FOR LYS63-LINKED POLYUBIQUITIN ANDTITL 3 REVEALS A B-BOX MODULEREF MOL.CELL.BIOL. V. 29 451 2008REFN ISSN 0270-7306PMID 18313383DOI 10.1016/J.MOLCEL.2007.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2dl6 CHD8 solution structure of the first brk domain from human chromodomain-helicase-dna-binding protein 8 -1.0Å AUTH T.SUETAKE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST BRK DOMAIN FROMTITL 2 HUMAN CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2fe4 RAB6B the crystal structure of human neuronal rab6b in its inactive gdp-bound form 2.3Å AUTH I.GARCIA-SAEZ,S.TCHERNIUK,F.KOZIELSKITITL THE STRUCTURE OF HUMAN NEURONAL RAB6B IN THETITL 2 ACTIVE AND INACTIVE FORM.REF ACTA CRYSTALLOGR.,SECT.D V. 62 725 2006REFN ISSN 0907-4449PMID 16790928DOI 10.1107/S0907444906015319 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2z0b GPCPD1 crystal structure of cbm20 domain of human putative glycerophosphodiester phosphodiesterase 5 (kiaa1434) 2.0Å AUTH S.SAIJO,A.NISHINO,S.KISHISHITA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF CBM20 DOMAIN OF HUMAN PUTATIVETITL 2 GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE 5 (KIAA1434)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ek1 RBM12 crystal structure of rna-binding motif of human rna-binding protein 12 2.0Å AUTH IHSANAWATI,Y.BESSHO,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF RNA-BINDING MOTIF OF HUMANTITL 2 RNA-BINDING PROTEIN 12REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1whm CYLD solution structure of the 2nd cap-gly domain in human cylindromatosis tumor suppressor cyld -1.0Å AUTH K.SAITOK,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 2ND CAP-GLY DOMAIN INTITL 2 HUMAN CYLINDROMATOSIS TUMOR SUPPRESSOR CYLDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ux3 FAM96A crystal structure of domain-swapped fam96a minor dimer 1.8Å AUTH K.-E.CHEN,A.A.RICHARDS,J.K.ARIFFIN,I.L.ROSS,M.J.SWEET,AUTH 2 S.KELLIE,B.KOBE,J.L.MARTINTITL THE MAMMALIAN DUF59 PROTEIN FAM96A FORMS TWO DISTINCT TYPESTITL 2 OF DOMAIN-SWAPPED DIMERREF ACTA CRYSTALLOGR.,SECT.D V. 68 637 2012REFN ISSN 0907-4449DOI 10.1107/S0907444912006592 Variant Set Distributions Mapped Variants