Assessment of Structural Intolerance and Durability
General Structure Information 4hlj ROBO1 axon guidance receptor 1.8Å AUTH R.BARAK,Y.OPATOWSKYTITL CRYSTAL STRUCTURE OF AXON GUIDANCE RECEPTORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lq3 CHKB crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide 1.42Å AUTH B.S.HONG,A.ALLALI-HASSANI,W.TEMPEL,P.J.FINERTY,F.MACKENZIE,AUTH 2 S.DIMOV,M.VEDADI,H.W.PARKTITL CRYSTAL STRUCTURES OF HUMAN CHOLINE KINASE ISOFORMS INTITL 2 COMPLEX WITH HEMICHOLINIUM-3: SINGLE AMINO ACID NEAR THETITL 3 ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY.REF J.BIOL.CHEM. V. 285 16330 2010REFN ISSN 0021-9258PMID […]
General Structure Information 2d2z CLIC4 crystal structure of soluble form of clic4 2.2Å AUTH Y.F.LI,D.F.LI,Z.H.ZENG,D.C.WANGTITL TRIMERIC STRUCTURE OF THE WILD SOLUBLE CHLORIDETITL 2 INTRACELLULAR ION CHANNEL CLIC4 OBSERVED INTITL 3 CRYSTALSREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 343 1272 2006REFN ISSN 0006-291XPMID 16581025DOI 10.1016/J.BBRC.2006.03.099 Variant Set Distributions Mapped Variants
General Structure Information 3e0l GDA computationally designed ammelide deaminase 2.37Å AUTH P.M.MURPHY,J.M.BOLDUC,J.L.GALLAHER,B.L.STODDARD,AUTH 2 D.BAKERTITL ALTERATION OF ENZYME SPECIFICITY BY COMPUTATIONALTITL 2 LOOP REMODELING AND DESIGN.REF PROC.NATL.ACAD.SCI.USA V. 106 9215 2009REFN ISSN 0027-8424PMID 19470646DOI 10.1073/PNAS.0811070106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vpd PYGO1 decoding of methylated histone h3 tail by the pygo-bcl9 wnt signaling complex 2.77Å AUTH M.FIEDLER,M.J.SANCHEZ-BARRENA,M.NEKRASOV,AUTH 2 J.MIESZCZANEK,V.RYBIN,J.MULLER,P.EVANS,M.BIENZTITL DECODING OF METHYLATED HISTONE H3 TAIL BY THETITL 2 PYGO- BCL9 WNT SIGNALING COMPLEX.REF MOL.CELL V. 30 507 2008REFN ISSN 1097-2765PMID 18498752DOI 10.1016/J.MOLCEL.2008.03.011 Variant Set Distributions Mapped Variants
General Structure Information 2z6e DAAM1 crystal structure of human daam1 fh2 2.8Å AUTH M.YAMASHITA,T.HIGASHI,S.SUETSUGU,Y.SATO,T.IKEDA,AUTH 2 R.SHIRAKAWA,T.KITA,T.TAKENAWA,H.HORIUCHI,S.FUKAI,AUTH 3 O.NUREKITITL CRYSTAL STRUCTURE OF HUMAN DAAM1 FORMIN HOMOLOGY 2TITL 2 DOMAINREF GENES CELLS V. 12 1255 2007REFN ISSN 1356-9597PMID 17986009DOI 10.1111/J.1365-2443.2007.01132.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1inz EPN1 solution structure of the epsin n-terminal homology (enth) domain of human epsin -1.0Å AUTH S.KOSHIBA,T.KIGAWA,A.KIKUCHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE EPSIN N-TERMINALTITL 2 HOMOLOGY (ENTH) DOMAIN OF HUMAN EPSINREF J.STRUCT.FUNCT.GENOM. V. 2 1 2001REFN ISSN 1345-711XPMID 12836669DOI 10.1023/A:1011397007366 Variant Set Distributions Mapped Variants
General Structure Information 1x5n USH1C solution structure of the second pdz domain of harmonin protein -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND PDZ DOMAIN OFTITL 2 HARMONIN PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2qfe CAPN7 distal c2-like domain of human calpain-7 1.45Å AUTH J.R.WALKER,D.CUERRIER,R.RAVULAPALLI,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL STRUCTURE OF THE C2 DOMAIN OF HUMAN CALPAIN-7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3r8k HEBP2 crystal structure of human soul protein (hexagonal form) 2.85Å AUTH E.AMBROSI,S.CAPALDI,M.BOVI,G.SACCOMANI,M.PERDUCA,H.L.MONACOTITL STRUCTURAL CHANGES IN THE BH3 DOMAIN OF SOUL PROTEIN UPONTITL 2 INTERACTION WITH THE ANTI-APOPTOTIC PROTEIN BCL-XL.REF BIOCHEM.J. V. 438 291 2011REFN ISSN 0264-6021PMID 21639858DOI 10.1042/BJ20110257 Variant Set Distributions Mapped Variants