Assessment of Structural Intolerance and Durability
General Structure Information 2ec1 NUP50 solution structure of the ranbd1 domain from human nucleoporin 50 kda -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RANBD1 DOMAIN FROM HUMANTITL 2 NUCLEOPORIN 50 KDAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wi1 CADPS solution structure of the ph domain of human calcium- dependent activator protein for secretion (caps) -1.0Å AUTH M.YONEYAMA,K.IZUMI,M.YOSHIDA,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF HUMANTITL 2 CALCIUM-DEPENDENT ACTIVATOR PROTEIN FOR SECRETIONTITL 3 (CAPS)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fnw ALK crystal structure of the apo f1174l anaplastic lymphoma kinase catalytic domain 1.75Å AUTH L.F.EPSTEIN,H.CHEN,R.EMKEY,D.A.WHITTINGTONTITL THE R1275Q NEUROBLASTOMA MUTANT AND CERTAIN ATP-COMPETITIVETITL 2 INHIBITORS STABILIZE ALTERNATIVE ACTIVATION LOOPTITL 3 CONFORMATIONS OF ANAPLASTIC LYMPHOMA KINASE.REF J.BIOL.CHEM. V. 287 37447 2012REFN ISSN 0021-9258PMID 22932897DOI 10.1074/JBC.M112.391425 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4f9b DBF4 human cdc7 kinase in complex with dbf4 and pha767491 2.5Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Mapped Variants
General Structure Information 3wh2 CLEC4E human mincle in complex with citrate 1.3Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3in5 POLK structure of human dna polymerase kappa inserting datp opposite an 8-oxog dna lesion 3.2Å AUTH R.VASQUEZ-DEL CARPIO,T.D.SILVERSTEIN,S.LONE,AUTH 2 M.K.SWAN,J.R.CHOUDHURY,R.E.JOHNSON,S.PRAKASH,AUTH 3 L.PRAKASH,A.K.AGGARWALTITL STRUCTURE OF HUMAN DNA POLYMERASE KAPPA INSERTINGTITL 2 DATP OPPOSITE AN 8-OXOG DNA LESIONREF PLOS ONE V. 4 E5766 2009REFN ESSN 1932-6203PMID 19492058DOI 10.1371/JOURNAL.PONE.0005766 Variant Set Distributions Pathogenic Proximity […]
General Structure Information 1d4b CIDEB cide-n domain of human cide-b -1.0Å AUTH A.A.LUGOVSKOY,P.ZHOU,J.J.CHOU,J.S.MCCARTY,P.LI,AUTH 2 G.WAGNERTITL SOLUTION STRUCTURE OF THE CIDE-N DOMAIN OF CIDE-BTITL 2 AND A MODEL FOR CIDE-N/CIDE-N INTERACTIONS IN THETITL 3 DNA FRAGMENTATION PATHWAY OF APOPTOSIS.REF CELL(CAMBRIDGE,MASS.) V. 99 747 1999REFN ISSN 0092-8674PMID 10619428DOI 10.1016/S0092-8674(00)81672-4 Variant Set Distributions Mapped Variants
General Structure Information 1j0w DOK5 crystal structure analysis of the dok-5 ptb domain 2.5Å AUTH N.SHI,Y.DING,B.Q.QIANG,J.G.YUAN,Z.H.RAOTITL CRYSTAL STRUCTURE ANALYSIS OF THE DOK-5 PTB DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ss6 NSFL1C solution structure of sep domain from human p47 -1.0Å AUTH M.SOUKENIK,A.DIEHL,M.LEIDERT,V.SIEVERT,K.BUESSOW,AUTH 2 D.LEITNER,D.LABUDDE,L.J.BALL,A.LECHNER,D.K.NAGLER,AUTH 3 H.OSCHKINATTITL THE SEP DOMAIN OF P47 ACTS AS A REVERSIBLETITL 2 COMPETITIVE INHIBITOR OF CATHEPSIN LREF FEBS LETT. V. 576 358 2004REFN ISSN 0014-5793PMID 15498563DOI 10.1016/J.FEBSLET.2004.09.037 Variant Set Distributions Mapped Variants
General Structure Information 2xph SENP1 crystal structure of human senp1 with the bound cobalt 2.4Å AUTH V.RIMSA,T.EADSFORTH,R.T.HAY,W.N.HUNTERTITL THE ROLE OF CO2+ IN THE CRYSTALLIZATION OF HUMAN SENP1 ANDTITL 2 COMMENTS ON THE LIMITATIONS OF AUTOMATED REFINEMENTTITL 3 PROTOCOLSREF ACTA CRYSTALLOGR.,SECT.F V. 67 442 2011REFN ISSN 1744-3091PMID 21505236DOI 10.1107/S1744309111005835 Variant Set Distributions Mapped Variants