Assessment of Structural Intolerance and Durability
General Structure Information 4lu3 CA14 the crystal structure of the human carbonic anhydrase xiv 2.0Å AUTH V.ALTERIO,P.PAN,S.PARKKILA,M.BUONANNO,C.T.SUPURAN,S.M.MONTI,AUTH 2 G.DE SIMONETITL THE STRUCTURAL COMPARISON BETWEEN MEMBRANE-ASSOCIATED HUMANTITL 2 CARBONIC ANHYDRASES PROVIDES INSIGHTS INTO DRUG DESIGN OFTITL 3 SELECTIVE INHIBITORS.REF BIOPOLYMERS V. 101 769 2014REFN ISSN 0006-3525PMID 24374484DOI 10.1002/BIP.22456 Variant Set Distributions Mapped Variants
General Structure Information 2lkt RARRES3 solution structure of n-terminal domain of human tig3 in 2 m urea -1.0Å AUTH L.WANG,W.YU,X.REN,J.LIN,C.JIN,B.XIATITL (1)H, (13)C, AND (15)N RESONANCE ASSIGNMENTS OF THETITL 2 N-TERMINAL DOMAIN OF HUMAN TIG3REF BIOMOL.NMR ASSIGN. V. 6 201 2012REFN ISSN 1874-2718PMID 22290676DOI 10.1007/S12104-012-9357-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4g34 EIF2AK3 crystal structure of gsk6924 bound to perk (r587-r1092, delete a660- t867) at 2.70 a resolution 2.7Å AUTH J.M.AXTEN,J.R.MEDINA,Y.FENG,A.SHU,S.P.ROMERIL,S.W.GRANT,AUTH 2 W.H.LI,D.A.HEERDING,E.MINTHORN,T.MENCKEN,C.ATKINS,Q.LIU,AUTH 3 S.RABINDRAN,R.KUMAR,X.HONG,A.GOETZ,T.STANLEY,J.D.TAYLOR,AUTH 4 S.D.SIGETHY,G.H.TOMBERLIN,A.M.HASSELL,K.M.KAHLER,AUTH 5 L.M.SHEWCHUK,R.T.GAMPETITL DISCOVERY OFTITL 2 7-METHYL-5-(1-{[3-(TRIFLUOROMETHYL)PHENYL]ACETYL}-2,3-TITL 3 DIHYDRO-1H-INDOL-5-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINETITL 4 (GSK2606414), A POTENT AND SELECTIVE FIRST-IN-CLASSTITL 5 INHIBITOR OF PROTEIN KINASE R (PKR)-LIKE ENDOPLASMICTITL 6 RETICULUM KINASE […]
General Structure Information 3rzn GLTP crystal structure of human glycolipid transfer protein complexed with 3-o-sulfo-galactosylceramide containing nervonoyl acyl chain (24:1) 1.1Å AUTH V.R.SAMYGINA,A.N.POPOV,A.CABO-BILBAO,B.OCHOA-LIZARRALDE,AUTH 2 F.GONI-DE-CERIO,X.ZHAI,J.G.MOLOTKOVSKY,D.J.PATEL,R.E.BROWN,AUTH 3 L.MALININATITL ENHANCED SELECTIVITY FOR SULFATIDE BY ENGINEERED HUMANTITL 2 GLYCOLIPID TRANSFER PROTEIN.REF STRUCTURE V. 19 1644 2011REFN ISSN 0969-2126PMID 22078563DOI 10.1016/J.STR.2011.09.011 Variant Set Distributions Mapped Variants
General Structure Information 2kdg MYOT solution structure of the 1st ig domain of myotilin -1.0Å AUTH O.HEIKKINEN,P.PERMI,H.KOSKELA,O.CARPEN,J.YLANNE,AUTH 2 I.KILPELAINENTITL SOLUTION STRUCTURE OF THE FIRST IMMUNOGLOBULINTITL 2 DOMAIN OF HUMAN MYOTILINREF J.BIOMOL.NMR V. 44 107 2009REFN ISSN 0925-2738PMID 19418025DOI 10.1007/S10858-009-9320-4 Variant Set Distributions Mapped Variants
General Structure Information 4ch9 KLHL3 crystal structure of the human klhl3 kelch domain in complex with a wnk4 peptide 1.84Å AUTH F.SCHUMACHER,F.J.SORRELL,D.R.ALESSI,A.N.BULLOCK,T.KURZTITL STRUCTURAL AND BIOCHEMICAL CHARACTERISATION OF THE KLHL3-TITL 2 WNK KINASE INTERACTION IMPORTANT IN BLOOD PRESSURETITL 3 REGULATION.REF BIOCHEM.J. V. 460 237 2014REFN ISSN 0264-6021PMID 24641320DOI 10.1042/BJ20140153 Variant Set Distributions Mapped Variants
General Structure Information 1iur SACS dnaj domain of human kiaa0730 protein -1.0Å AUTH N.KOBAYASHI,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF DNAJ DOMAIN OF HUMANTITL 2 KIAA0730 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3u10 HCN2 tetramerization dynamics of the c-terminus underlies isoform-specific camp-gating in hcn channels 2.3Å AUTH M.LOLICATO,M.NARDINI,S.GAZZARRINI,S.MOLLER,D.BERTINETTI,AUTH 2 F.W.HERBERG,M.BOLOGNESI,H.MARTIN,M.FASOLINI,J.A.BERTRAND,AUTH 3 C.ARRIGONI,G.THIEL,A.MORONITITL TETRAMERIZATION DYNAMICS OF C-TERMINAL DOMAIN UNDERLIESTITL 2 ISOFORM-SPECIFIC CAMP GATING IN HYPERPOLARIZATION-ACTIVATEDTITL 3 CYCLIC NUCLEOTIDE-GATED CHANNELS.REF J.BIOL.CHEM. V. 286 44811 2011REFN ISSN 0021-9258PMID 22006928DOI 10.1074/JBC.M111.297606 Variant Set Distributions Mapped Variants
General Structure Information 2los TMEM14C backbone structure of human membrane protein tmem14c -1.0Å AUTH C.KLAMMT,I.MASLENNIKOV,M.BAYRHUBER,C.EICHMANN,N.VAJPAI,AUTH 2 E.J.CHIU,K.Y.BLAIN,L.ESQUIVIES,J.H.KWON,B.BALANA,U.PIEPER,AUTH 3 A.SALI,P.A.SLESINGER,W.KWIATKOWSKI,R.RIEK,S.CHOETITL FACILE BACKBONE STRUCTURE DETERMINATION OF HUMAN MEMBRANETITL 2 PROTEINS BY NMR SPECTROSCOPY.REF NAT.METHODS V. 9 834 2012REFN ISSN 1548-7091PMID 22609626DOI 10.1038/NMETH.2033 Variant Set Distributions Mapped Variants
General Structure Information 2ltm NFU1 solution nmr structure of nfu1 iron-sulfur cluster scaffold homolog from homo sapiens, northeast structural genomics consortium (nesg) target hr2876b -1.0Å AUTH G.LIU,R.XIAO,H.JANJUA,K.HAMILTON,R.SHASTRY,E.KOHAN,AUTH 2 T.B.ACTON,J.K.EVERETT,H.LEE,Y.J.HUANG,G.T.MONTELIONETITL SOLUTION NMR STRUCTURE OF NFU1 IRON-SULFUR CLUSTER SCAFFOLDTITL 2 HOMOLOG FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICSTITL 3 CONSORTIUM (NESG) TARGET HR2876BREF TO BE PUBLISHEDREFN Variant Set […]