Assessment of Structural Intolerance and Durability
General Structure Information 2qms GRB7 crystal structure of a signaling molecule 2.1Å AUTH C.J.PORTER,J.M.MATTHEWS,J.P.MACKAY,S.E.PURSGLOVE,AUTH 2 J.W.SCHMIDBERGER,P.J.LEEDMAN,S.C.PERO,D.N.KRAG,AUTH 3 M.C.WILCE,J.A.WILCETITL GRB7 SH2 DOMAIN STRUCTURE AND INTERACTIONS WITH ATITL 2 CYCLIC PEPTIDE INHIBITOR OF CANCER CELL MIGRATIONTITL 3 AND PROLIFERATION.REF BMC STRUCT.BIOL. V. 7 58 2007REFN ESSN 1472-6807PMID 17894853DOI 10.1186/1472-6807-7-58 Variant Set Distributions Mapped Variants
General Structure Information 2v7o CAMK2G crystal structure of human calcium-calmodulin-dependent protein kinase ii gamma 2.25Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4epu ANGPT1 ang1 fibrinogen-related domain (fred) 2.1Å AUTH C.C.YEYKAL,L.SUNDARESAN,M.MRKSICH,E.J.ADAMSTITL BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THE ANG1TITL 2 FIBRINOGEN-RELATED DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2i99 CRYM crystal structure of human mu_crystallin at 2.6 angstrom 2.6Å AUTH Z.CHENG,L.SUN,J.HE,W.GONGTITL CRYSTAL STRUCTURE OF HUMAN {MICRO}-CRYSTALLIN COMPLEXED WITHTITL 2 NADPHREF PROTEIN SCI. V. 16 329 2007REFN ISSN 0961-8368PMID 17242435DOI 10.1110/PS.062556907 Variant Set Distributions Mapped Variants
General Structure Information 2dll IRF4 solution structure of the irf domain of human interferon regulator factors 4 -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IRF DOMAIN OF HUMANTITL 2 INTERFERON REGULATOR FACTORS 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2y05 PTGR1 crystal structure of human leukotriene b4 12-hydroxydehydrogenase in complex with nadp and raloxifene 2.2Å AUTH W.W.YUE,N.SHAFQAT,T.KROJER,A.C.W.PIKE,F.VON DELFT,R.SETHI,AUTH 2 P.SAVITSKY,C.JOHANSSON,C.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 3 C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN LEUKOTRIENE B4TITL 2 12-HYDROXYDEHYDROGENASE IN COMPLEX WITH NADP AND RALOXIFENEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kgt PTK6 solution structure of sh3 domain of ptk6 -1.0Å AUTH W.LEE,S.KOTITL THE SOLUTION STRUCTURE OF SH3 DOMAIN OF PTK6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1y7q ZNF174 mammalian scan domain dimer is a domain-swapped homologue of the hiv capsid c-terminal domain -1.0Å AUTH D.IVANOV,J.R.STONE,J.L.MAKI,T.COLLINS,G.WAGNERTITL MAMMALIAN SCAN DOMAIN DIMER IS A DOMAIN-SWAPPEDTITL 2 HOMOLOG OF THE HIV CAPSID C-TERMINAL DOMAINREF MOL.CELL V. 17 137 2005REFN ISSN 1097-2765PMID 15629724DOI 10.1016/J.MOLCEL.2004.12.015 Variant Set Distributions Mapped Variants
General Structure Information 1wi5 PDCD11 solution structure of the s1 rna binding domain from human hypothetical protein baa11502 -1.0Å AUTH S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE S1 RNA BINDING DOMAINTITL 2 FROM HUMAN HYPOTHETICAL PROTEIN BAA11502REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4ku8 PRKG1 structures of pkgi reveal a cgmp-selective activation mechanism 1.99Å AUTH G.Y.HUANG,J.J.KIM,A.S.REGER,R.LORENZ,E.W.MOON,C.ZHAO,AUTH 2 D.E.CASTEEL,D.BERTINETTI,B.VANSCHOUWEN,R.SELVARATNAM,AUTH 3 J.W.PFLUGRATH,B.SANKARAN,G.MELACINI,F.W.HERBERG,C.KIMTITL STRUCTURAL BASIS FOR CYCLIC-NUCLEOTIDE SELECTIVITY ANDTITL 2 CGMP-SELECTIVE ACTIVATION OF PKG I.REF STRUCTURE V. 22 116 2014REFN ISSN 0969-2126PMID 24239458DOI 10.1016/J.STR.2013.09.021 Variant Set Distributions Mapped Variants