Assessment of Structural Intolerance and Durability
General Structure Information 2q5a PIN1 human pin1 bound to l-peptide 1.5Å AUTH Y.ZHANG,S.DAUM,D.WILDEMANN,X.Z.ZHOU,M.A.VERDECIA,M.E.BOWMAN,AUTH 2 C.LUCKE,T.HUNTER,K.P.LU,G.FISCHER,J.P.NOELTITL STRUCTURAL BASIS FOR HIGH-AFFINITY PEPTIDE INHIBITION OFTITL 2 HUMAN PIN1.REF ACS CHEM.BIOL. V. 2 320 2007REFN ISSN 1554-8929PMID 17518432DOI 10.1021/CB7000044 Variant Set Distributions Mapped Variants
General Structure Information 2yqg DSG2 solution structure of the first cadherin domain from human desmoglein-2 -1.0Å AUTH R.SANO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST CADHERIN DOMAINTITL 2 FROM HUMAN DESMOGLEIN-2REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dbr NAE1 structural dissection of a gating mechanism preventing misactivation of ubiquitin by nedd8s e1 (appbp1- uba3arg190gln-nedd8ala72arg) 3.05Å AUTH J.SOUPHRON,M.B.WADDELL,A.PAYDAR,Z.TOKGOZ-GROMLEY,AUTH 2 M.F.ROUSSEL,B.A.SCHULMANTITL STRUCTURAL DISSECTION OF A GATING MECHANISMTITL 2 PREVENTING MISACTIVATION OF UBIQUITIN BY NEDD8STITL 3 E1.REF BIOCHEMISTRY V. 47 8961 2008REFN ISSN 0006-2960PMID 18652489DOI 10.1021/BI800604C Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2yw5 BRD3 solution structure of the bromodomain from human bromodomain containing protein 3 -1.0Å AUTH M.FURUE,S.SUZUKI,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BROMODOMAIN FROM HUMANTITL 2 BROMODOMAIN CONTAINING PROTEIN 3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1upt GOLGA4 structure of a complex of the golgin-245 grip domain with arl1 1.7Å AUTH B.PANIC,O.PERISIC,D.B.VEPRINTSEV,R.L.WILLIAMS,AUTH 2 S.MUNROTITL STRUCTURAL BASIS FOR ARL1-DEPENDENT TARGETING OFTITL 2 HOMODIMERIC GRIP DOMAINS TO THE GOLGI APPARATUSREF MOL.CELL V. 12 863 2003REFN ISSN 1097-2765PMID 14580338DOI 10.1016/S1097-2765(03)00356-3 Variant Set Distributions Mapped Variants
General Structure Information 2v7c NR1D2 crystal structure of rev-erb beta 2.4Å AUTH E.-J.WOO,D.G.JEONG,M.-Y.LIM,S.J.KIM,K.-J.KIM,AUTH 2 S.-M.YOON,B.-C.PARK,S.E.RYUTITL STRUCTURAL INSIGHT INTO THE CONSTITUTIVETITL 2 REPRESSION FUNCTION OF THE NUCLEAR RECEPTORTITL 3 REV-ERBBETAREF J.MOL.BIOL. V. 373 735 2007REFN ISSN 0022-2836PMID 17870090DOI 10.1016/J.JMB.2007.08.037 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ldj CUL1 structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex 3.0Å AUTH N.ZHENG,B.A.SCHULMAN,L.SONG,J.J.MILLER,P.D.JEFFREY,AUTH 2 P.WANG,C.CHU,D.M.KOEPP,S.J.ELLEDGE,M.PAGANO,AUTH 3 R.C.CONAWAY,J.W.CONAWAY,J.W.HARPER,N.P.PAVLETICHTITL STRUCTURE OF THE CUL1-RBX1-SKP1-F BOXSKP2 SCFTITL 2 UBIQUITIN LIGASE COMPLEX.REF NATURE V. 416 703 2002REFN ISSN 0028-0836PMID 11961546DOI 10.1038/416703A Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2i6k IDI1 crystal structure of human type i ipp isomerase complexed with a substrate analog 2.0Å AUTH C.ZHANG,L.LIU,H.XU,Z.WEI,Y.WANG,Y.LIN,W.GONGTITL CRYSTAL STRUCTURES OF HUMAN IPP ISOMERASE: NEWTITL 2 INSIGHTS INTO THE CATALYTIC MECHANISMREF J.MOL.BIOL. V. 366 1437 2007REFN ISSN 0022-2836PMID 17137593DOI 10.1016/J.JMB.2006.10.092 Variant Set Distributions Mapped Variants
General Structure Information 2nxp TAF5 structure of ntd2 domain of the human taf5 subunit of tfiid 2.17Å AUTH S.BHATTACHARYA,S.TAKADA,R.H.JACOBSONTITL STRUCTURAL ANALYSIS AND DIMERIZATION POTENTIAL OFTITL 2 THE HUMAN TAF5 SUBUNIT OF TFIID.REF PROC.NATL.ACAD.SCI.USA V. 104 1189 2007REFN ISSN 0027-8424PMID 17227857DOI 10.1073/PNAS.0610297104 Variant Set Distributions Mapped Variants
General Structure Information 4bl1 MELK crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex with amp-pnp 2.6Å AUTH G.CANEVARI,S.RE-DEPAOLINI,U.CUCCHI,B.FORTE,P.CARPINELLI,AUTH 2 J.A.BERTRANDTITL CRYSTAL STRUCTURE OF UNPHOSPHORYLATED MATERNAL EMBRYONICTITL 2 LEUCINE ZIPPER KINASEREF TO BE PUBLISHED Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants