Assessment of Structural Intolerance and Durability
General Structure Information 3czh CYP2R1 crystal structure of cyp2r1 in complex with vitamin d2 2.3Å AUTH N.V.STRUSHKEVICH,W.TEMPEL,A.A.GILEP,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITHTITL 2 VITAMIN D2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1i1j MIA structure of melanoma inhibitory activity protein: a member of a new family of secreted proteins 1.39Å AUTH J.C.LOUGHEED,J.M.HOLTON,T.ALBER,J.F.BAZAN,AUTH 2 T.M.HANDELTITL STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN,TITL 2 A MEMBER OF A RECENTLY IDENTIFIED FAMILY OFTITL 3 SECRETED PROTEINS.REF PROC.NATL.ACAD.SCI.USA V. 98 5515 2001REFN ISSN 0027-8424PMID 11331761DOI 10.1073/PNAS.091601698 Variant Set Distributions […]
General Structure Information 2g59 PTPRO crystal structure of the catalytic domain of protein tyrosine phosphatase from homo sapiens 2.19Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3f4m TNFAIP8L2 crystal structure of tipe2 1.7Å AUTH X.ZHANG,J.WANG,C.FAN,H.LI,H.SUN,S.GONG,Y.H.CHEN,AUTH 2 Y.SHITITL CRYSTAL STRUCTURE OF TIPE2 PROVIDES INSIGHTS INTOTITL 2 IMMUNE HOMEOSTASISREF NAT.STRUCT.MOL.BIOL. V. 16 89 2009REFN ISSN 1545-9993PMID 19079267DOI 10.1038/NSMB.1522 Variant Set Distributions Mapped Variants
General Structure Information 3b9c LGALSL crystal structure of human grp crd 1.9Å AUTH D.ZHOU,H.GE,J.SUN,Y.GAO,M.TENG,L.NIUTITL CRYSTAL STRUCTURE OF THE C-TERMINAL CONSERVEDTITL 2 DOMAIN OF HUMAN GRP, A GALECTIN-RELATED PROTEIN,TITL 3 REVEALS A FUNCTION MODE DIFFERENT FROM THOSE OFTITL 4 GALECTINS.REF PROTEINS V. 71 1582 2008REFN ISSN 0887-3585PMID 18320588DOI 10.1002/PROT.22003 Variant Set Distributions Mapped Variants
General Structure Information 2dwp PFKFB3 a pseudo substrate complex of 6-phosphofructo-2-kinase of pfkfb 2.7Å AUTH S.G.KIM,M.CAVALIER,M.R.EL-MAGHRABI,Y.H.LEETITL A DIRECT SUBSTRATE-SUBSTRATE INTERACTION FOUND INTITL 2 THE KINASE DOMAIN OF THE BIFUNCTIONAL ENZYME,TITL 3 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-TITL 4 BISPHOSPHATASEREF J.MOL.BIOL. V. 370 14 2007REFN ISSN 0022-2836PMID 17499765DOI 10.1016/J.JMB.2007.03.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3kv5 KDM7A structure of kiaa1718, human jumonji demethylase, in complex with n-oxalylglycine 2.39Å AUTH J.R.HORTON,A.K.UPADHYAY,H.H.QI,X.ZHANG,Y.SHI,AUTH 2 X.CHENGTITL ENZYMATIC AND STRUCTURAL INSIGHTS FOR SUBSTRATETITL 2 SPECIFICITY OF A FAMILY OF JUMONJI HISTONE LYSINETITL 3 DEMETHYLASES.REF NAT.STRUCT.MOL.BIOL. V. 17 38 2010REFN ISSN 1545-9993PMID 20023638DOI 10.1038/NSMB.1753 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4at4 NTRK2 crystal structure of trkb kinase domain in complex with ex429 2.36Å AUTH T.BERTRAND,M.KOTHE,J.LIU,A.DUPUY,A.RAK,P.F.BERNE,S.DAVIS,AUTH 2 T.GLADYSHEVA,C.VALTRE,J.Y.CRENNE,M.MATHIEUTITL THE CRYSTAL STRUCTURES OF TRKA AND TRKB SUGGEST KEY REGIONSTITL 2 FOR ACHIEVING SELECTIVE INHIBITION.REF J.MOL.BIOL. V. 423 439 2012REFN ISSN 0022-2836PMID 22902478DOI 10.1016/J.JMB.2012.08.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1w7n CCBL1 crystal structure of human kynurenine aminotransferase i in pmp form 2.9Å AUTH F.ROSSI,Q.HAN,J.LI,J.LI,M.RIZZITITL CRYSTAL STRUCTURE OF HUMAN KYNURENINETITL 2 AMINOTRANSFERASE IREF J.BIOL.CHEM. V. 279 50214 2004REFN ISSN 0021-9258PMID 15364907DOI 10.1074/JBC.M409291200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3vpp CLEC9A crystal structure of the human clec9a c-type lectin-like domain 1.64Å AUTH J.G.ZHANG,P.E.CZABOTAR,A.N.POLICHENI,I.CAMINSCHI,S.S.WAN,AUTH 2 S.KITSOULIS,K.M.TULLETT,A.Y.ROBIN,R.BRAMMANANTH,AUTH 3 M.F.VAN DELFT,J.LU,L.A.OREILLY,E.C.JOSEFSSON,B.T.KILE,AUTH 4 W.J.CHIN,J.D.MINTERN,M.A.OLSHINA,W.WONG,J.BAUM,M.D.WRIGHT,AUTH 5 D.C.HUANG,N.MOHANDAS,R.L.COPPEL,P.M.COLMAN,N.A.NICOLA,AUTH 6 K.SHORTMAN,M.H.LAHOUDTITL THE DENDRITIC CELL RECEPTOR CLEC9A BINDS DAMAGED CELLS VIATITL 2 EXPOSED ACTIN FILAMENTS.REF IMMUNITY V. 36 646 2012REFN ISSN 1074-7613PMID 22483802DOI 10.1016/J.IMMUNI.2012.03.009 Variant Set Distributions Mapped Variants