Assessment of Structural Intolerance and Durability
General Structure Information 3hzj RABGAP1L crystal structure of the rabgap domain of the rabgap1l protein 2.3Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,N.ZHONG,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RABGAP DOMAIN OF THETITL 2 RABGAP1L PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i1y PTPRN crystal structure of the phosphatase domain of human ptp ia-2 2.23Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,T.P.DILORENZO,AUTH 2 V.MALASHKEVICH,S.R.WASSERMAN,S.SWAMINATHAN,S.ESWARAMOORTHY,AUTH 3 R.AGARWAL,D.KUMARAN,M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,AUTH 4 J.ALVARADO,U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 5 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASESREF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2edt OBSCN solution structure of the ig-like domain (3449-3537) from human obscurin -1.0Å AUTH K.SEIMIYA,K IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IG-LIKE DOMAINTITL 2 (3449-3537) FROM HUMAN OBSCURINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2g6z DUSP5 crystal structure of human dusp5 2.7Å AUTH D.G.JEONG,Y.H.CHO,T.S.YOON,J.H.KIM,S.E.RYU,S.J.KIMTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMANTITL 2 DUSP5, A DUAL SPECIFICITY MAP KINASE PROTEINTITL 3 PHOSPHATASEREF PROTEINS V. 66 253 2007REFN ISSN 0887-3585PMID 17078075DOI 10.1002/PROT.21224 Variant Set Distributions Mapped Variants
General Structure Information 2ox8 COLEC12 human scavenger receptor c-type lectin carbohydrate- recognition domain. 2.5Å AUTH H.FEINBERG,M.E.TAYLOR,W.I.WEISTITL SCAVENGER RECEPTOR C-TYPE LECTIN BINDS TO THETITL 2 LEUKOCYTE CELL SURFACE GLYCAN LEWIS(X) BY A NOVELTITL 3 MECHANISM.REF J.BIOL.CHEM. V. 282 17250 2007REFN ISSN 0021-9258PMID 17420244DOI 10.1074/JBC.M701624200 Variant Set Distributions Mapped Variants
General Structure Information 3nbq UPP1 human uridine phosphorylase 1 (hupp1) with 5-fluorouracil 2.3Å AUTH T.P.ROOSILD,S.CASTRONOVOTITL ACTIVE SITE CONFORMATIONAL DYNAMICS IN HUMAN URIDINETITL 2 PHOSPHORYLASE 1.REF PLOS ONE V. 5 E1274 2010REFN ESSN 1932-6203PMID 20856879DOI 10.1371/JOURNAL.PONE.0012741 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2mdg ZNF423 solution nmr structure of zinc finger protein 423 from homo sapiens, northeast structural genomics consortium (nesg) target hr7298f -1.0Å AUTH K.PEDERSON,D.LEE,E.KOHAN,H.JANJUA,R.XIAO,J.K.EVERETT,AUTH 2 T.B.ACTON,G.T.MONTELIONE,J.H.PRESTEGARDTITL SOLUTION NMR STRUCTURE OF ZINC FINGER PROTEIN 423 FROM HOMOTITL 2 SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG)TITL 3 TARGET HR7298FREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 4bkf EFNB3 crystal structure of the human epha4 ectodomain in complex with human ephrinb3 4.65Å AUTH E.SEIRADAKE,A.SCHAUPP,D.DEL TORO RUIZ,R.KAUFMANN,AUTH 2 N.MITAKIDIS,K.HARLOS,A.R.ARICESCU,R.KLEIN,E.Y.JONESTITL STRUCTURALLY ENCODED INTRACLASS DIFFERENCES IN EPHATITL 2 CLUSTERS DRIVE DISTINCT CELL RESPONSESREF NAT.STRUCT.MOL.BIOL. V. 20 958 2013REFN ISSN 1545-9993PMID 23812375DOI 10.1038/NSMB.2617 Variant Set Distributions Mapped Variants
General Structure Information 4ad9 LACTB2 crystal structure of human lactb2. 2.6Å AUTH C.K.ALLERSTON,T.KROJER,O.GILEADITITL CRYSTAL STRUCTURE OF HUMAN LACTB2.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vpj KLHL12 crystal structure of the kelch domain of human klhl12 1.85Å AUTH P.CANNING,C.D.O.COOPER,T.KROJER,J.W.MURRAY,A.C.W.PIKE,AUTH 2 A.CHAIKUAD,T.KEATES,C.THANGARATNARAJAH,V.HOJZAN,B.D.MARSDEN,AUTH 3 O.GILEADI,S.KNAPP,F.VON DELFT,A.N.BULLOCKTITL STRUCTURAL BASIS FOR CUL3 ASSEMBLY WITH THE BTB-KELCHTITL 2 FAMILY OF E3 UBIQUITIN LIGASES.REF J.BIOL.CHEM. V. 288 7803 2013REFN ISSN 0021-9258PMID 23349464DOI 10.1074/JBC.M112.437996 Variant Set Distributions Mapped Variants