Assessment of Structural Intolerance and Durability
General Structure Information 4k92 CLASP1 a cryptic tog domain with a distinct architecture underlies clasp- dependent bipolar spindle formation 2.0Å AUTH J.B.LEANO,S.L.ROGERS,K.C.SLEPTITL A CRYPTIC TOG DOMAIN WITH A DISTINCT ARCHITECTURE UNDERLIESTITL 2 CLASP-DEPENDENT BIPOLAR SPINDLE FORMATION.REF STRUCTURE V. 21 939 2013REFN ISSN 0969-2126PMID 23727231DOI 10.1016/J.STR.2013.04.018 Variant Set Distributions Mapped Variants
General Structure Information 2crr SMAP1 solution structure of arfgap domain from human smap1 -1.0Å AUTH T.SUETAKE,M.SATO,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF ARFGAP DOMAIN FROM HUMANTITL 2 SMAP1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3iu6 PBRM1 crystal structure of the sixth bromodomain of human poly-bromodomain containing protein 1 (pb1) 1.79Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4hae CDYL2 crystal structure of the cdyl2-chromodomain 2.0Å AUTH S.QIN,L.DOMBROVSKI,W.TEMPEL,A.DONG,C.XU,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,H.WUTITL CRYSTAL STRUCTURE OF THE CDYL2-CHROMODOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2m76 CPT1C structure of the regulatory domain of human brain carnitine palmitoyltransferase 1 -1.0Å AUTH S.SAMANTA,A.J.SITU,T.S.ULMERTITL STRUCTURAL CHARACTERIZATION OF THE REGULATORY DOMAIN OFTITL 2 BRAIN CARNITINE PALMITOYLTRANSFERASE 1.REF BIOPOLYMERS V. 101 398 2014REFN ISSN 0006-3525PMID 24037959DOI 10.1002/BIP.22396 Variant Set Distributions Mapped Variants
General Structure Information 2wqz NLGN4X crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement 3.9Å AUTH I.P.FABRICHNY,P.LEONE,G.SULZENBACHER,D.COMOLETTI,M.T.MILLER,AUTH 2 P.TAYLOR,Y.BOURNE,P.MARCHOTTITL STRUCTURAL ANALYSIS OF THE SYNAPTIC PROTEIN NEUROLIGIN ANDTITL 2 ITS BETA-NEUREXIN COMPLEX: DETERMINANTS FOR FOLDING ANDTITL 3 CELL ADHESION.REF NEURON V. 56 979 2007REFN ISSN 0896-6273PMID 18093521DOI 10.1016/J.NEURON.2007.11.013 Variant Set Distributions Ripley’s […]
General Structure Information 3evi PDCL2 crystal structure of the thioredoxin-fold domain of human phosducin- like protein 2 2.7Å AUTH X.LOU,R.BAO,C.Z.ZHOU,Y.CHENTITL STRUCTURE OF THE THIOREDOXIN-FOLD DOMAIN OF HUMANTITL 2 PHOSDUCIN-LIKE PROTEIN 2REF ACTA CRYSTALLOGR.,SECT.F V. 65 67 2009REFN ESSN 1744-3091PMID 19193988DOI 10.1107/S1744309108037342 Variant Set Distributions Mapped Variants
General Structure Information 3kt9 APTX aprataxin fha domain 1.65Å AUTH O.J.BECHEREL,B.JAKOB,A.L.CHERRY,N.GUEVEN,M.FUSSER,AUTH 2 A.W.KIJAS,C.PENG,S.KATYAL,P.J.MCKINNON,J.CHEN,AUTH 3 B.EPE,S.J.SMERDON,G.TAUCHER-SCHOLZ,M.F.LAVINTITL CK2 PHOSPHORYLATION-DEPENDENT INTERACTION BETWEENTITL 2 APRATAXIN AND MDC1 IN THE DNA DAMAGE RESPONSE.REF NUCLEIC ACIDS RES. V. 38 1489 2010REFN ISSN 0305-1048PMID 20008512DOI 10.1093/NAR/GKP1149 Variant Set Distributions Mapped Variants
General Structure Information 4fmw TRMT10A crystal structure of methyltransferase domain of human rna (guanine-9- ) methyltransferase domain containing protein 2 2.0Å AUTH H.ZENG,A.DONG,P.LOPPNAU,W.TEMPEL,C.BOUNTRA,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,H.WUTITL CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMAN RNATITL 2 (GUANINE-9-) METHYLTRANSFERASE DOMAIN CONTAINING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4n48 CMTR1 cap-specific mrna (nucleoside-2-o-)-methyltransferase 1 protein in complex with capped rna fragment 2.7Å AUTH M.SMIETANSKI,M.WERNER,E.PURTA,K.H.KAMINSKA,J.STEPINSKI,AUTH 2 E.DARZYNKIEWICZ,M.NOWOTNY,J.M.BUJNICKITITL STRUCTURAL ANALYSIS OF HUMAN 2-O-RIBOSE METHYLTRANSFERASESTITL 2 INVOLVED IN MRNA CAP STRUCTURE FORMATION.REF NAT COMMUN V. 5 3004 2014REFN ESSN 2041-1723PMID 24402442DOI 10.1038/NCOMMS4004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]