Assessment of Structural Intolerance and Durability
General Structure Information 2yrg TRIM5 solution structure of the b-box domain from tripartite motif-containing protein 5 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE B-BOX DOMAIN FROMTITL 2 TRIPARTITE MOTIF-CONTAINING PROTEIN 5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1jh4 PAIP1 solution structure of the c-terminal pabc domain of human poly(a)-binding protein in complex with the peptide from paip1 -1.0Å AUTH G.KOZLOV,G.DE CRESCENZO,N.S.LIM,N.SIDDIQUI,AUTH 2 D.FANTUS,A.KAHVEJIAN,J.F.TREMPE,D.ELIAS,I.EKIEL,AUTH 3 N.SONENBERG,M.OCONNOR-MCCOURT,K.GEHRINGTITL STRUCTURAL BASIS OF LIGAND RECOGNITION BY PABC, ATITL 2 HIGHLY SPECIFIC PEPTIDE-BINDING DOMAIN FOUND INTITL 3 POLY(A)-BINDING PROTEIN AND A HECT UBIQUITIN LIGASEREF EMBO […]
General Structure Information 3jw0 NEDD4L e2~ubiquitin-hect 3.1Å AUTH H.B.KAMADURAI,J.SOUPHRON,D.C.SCOTT,D.M.DUDA,D.J.MILLER,AUTH 2 D.STRINGER,R.C.PIPER,B.A.SCHULMANTITL INSIGHTS INTO UBIQUITIN TRANSFER CASCADES FROM A STRUCTURETITL 2 OF A UBCH5B APPROXIMATELY UBIQUITIN-HECT(NEDD4L) COMPLEX.REF MOL.CELL V. 36 1095 2009REFN ISSN 1097-2765PMID 20064473DOI 10.1016/J.MOLCEL.2009.11.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4b04 DUSP26 crystal structure of the catalytic domain of human dusp26 (c152s) 2.2Å AUTH E.-Y.WON,Y.XIE,C.TAKEMOTO,L.CHEN,Z.-J.LIU,B.C.WANG,D.LEE,AUTH 2 E.-J.WOO,S.G.PARK,M.SHIROUZU,S.YOKOYAMA,S.J.KIM,S.-W.CHITITL HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE CATALYTIC DOMAINTITL 2 OF HUMAN DUAL-SPECIFICITY PHOSPHATASE 26REF ACTA CRYSTALLOGR.,SECT.D V. 69 1160 2013REFN ISSN 0907-4449PMID 23695260DOI 10.1107/S0907444913004770 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4ldq MRI1 crystal structure of the mediator of rho dependent invasion 2.5Å AUTH P.D.TEMPLETON,E.S.LITMAN,S.I.METZNER,N.G.AHN,M.C.SOUSATITL STRUCTURE OF MEDIATOR OF RHOA-DEPENDENT INVASION (MRDI)TITL 2 EXPLAINS ITS DUAL FUNCTION AS A METABOLIC ENZYME AND ATITL 3 MEDIATOR OF CELL INVASION.REF BIOCHEMISTRY V. 52 5675 2013REFN ISSN 0006-2960PMID 23859498DOI 10.1021/BI400556E Variant Set Distributions Mapped Variants
General Structure Information 2yqm RUFY1 solution structure of the fyve domain in zinc finger fyve domain-containing protein 12 -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FYVE DOMAIN IN ZINCTITL 2 FINGER FYVE DOMAIN-CONTAINING PROTEIN 12REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2bo9 LXN human carboxypeptidase a4 in complex with human latexin. 1.6Å AUTH I.PALLARES,R.BONET,R.GARCIA-CASTELLANOS,S.VENTURA,AUTH 2 F.X.AVILES,J.VENDRELL,F.X.GOMIS-RUETHTITL STRUCTURE OF HUMAN CARBOXYPEPTIDASE A4 WITH ITSTITL 2 ENDOGENOUS PROTEIN INHIBITOR, LATEXIN.REF PROC.NATL.ACAD.SCI.USA V. 102 3978 2005REFN ISSN 0027-8424PMID 15738388DOI 10.1073/PNAS.0500678102 Variant Set Distributions Mapped Variants
General Structure Information 2kdb HERPUD2 solution structure of human ubiquitin-like domain of herpud2_9_85, northeast structural genomics consortium (nesg) target ht53a -1.0Å AUTH R.DOHERTY,B.WU,C.FARES,A.LEMAK,A.GUTMANAS,A.SEMESI,A.YEE,AUTH 2 C.H.ARROWSMITH,S.DHE-PAGANONTITL STRUCTURE OF HUMAN HOMOCYSTEINE-INDUCIBLE, ENDOPLASMICTITL 2 RETICULUM STRESS-INDUCIBLE, UBIQUITIN-LIKE DOMAIN MEMBER 2TITL 3 (HERPUD2 OR HERP)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wl4 ACAT2 human cytosolic acetoacetyl-coa thiolase complexed with coa 1.55Å AUTH P.KURSULA,H.SIKKILA,T.FUKAO,N.KONDO,R.K.WIERENGATITL HIGH RESOLUTION CRYSTAL STRUCTURES OF HUMAN CYTOSOLICTITL 2 THIOLASE (CT): A COMPARISON OF THE ACTIVE SITES OF HUMAN CT,TITL 3 BACTERIAL THIOLASE, AND BACTERIAL KAS IREF J.MOL.BIOL. V. 347 189 2005REFN ISSN 0022-2836PMID 15733928DOI 10.1016/J.JMB.2005.01.018 Variant Set Distributions Ripley’s K […]
General Structure Information 2jam CAMK1G crystal structure of human calmodulin-dependent protein kinase i g 1.7Å AUTH J.E.DEBRECZENI,A.BULLOCK,T.KEATES,F.H.NIESEN,AUTH 2 E.SALAH,L.SHRESTHA,C.SMEE,F.SOBOTT,A.C.W.PIKE,AUTH 3 G.BUNKOCZI,F.VON DELFT,A.TURNBULL,J.WEIGELT,AUTH 4 C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE I GREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants