Assessment of Structural Intolerance and Durability
General Structure Information 3pnw TDRD3 crystal structure of the tudor domain of human tdrd3 in complex with an anti-tdrd3 fab 2.05Å AUTH H.PERSSON,W.YE,A.WERNIMONT,J.J.ADAMS,A.KOIDE,S.KOIDE,R.LAM,AUTH 2 S.S.SIDHUTITL CDR-H3 DIVERSITY IS NOT REQUIRED FOR ANTIGEN RECOGNITION BYTITL 2 SYNTHETIC ANTIBODIES.REF J.MOL.BIOL. V. 425 803 2013REFN ISSN 0022-2836PMID 23219464DOI 10.1016/J.JMB.2012.11.037 Variant Set Distributions Mapped Variants
General Structure Information 2eeh PDZD7 solution structure of first pdz domain of pdz domain containing protein 7 -1.0Å AUTH T.N.NIRAULA,N.TOCHIO,T.TOMIZAWA,K.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF FIRST PDZ DOMAIN OF PDZTITL 2 DOMAIN CONTAINING PROTEIN 7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3zhp CAB39L human mst3 (stk24) in complex with mo25beta 2.9Å AUTH Y.MEHELLOU,D.R.ALESSI,T.J.MACARTNEY,M.SZKLARZ,S.KNAPP,AUTH 2 J.M.ELKINSTITL STRUCTURAL INSIGHTS INTO THE ACTIVATION OF MST3 BY MO25.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 431 604 2013REFN ISSN 0006-291XPMID 23296203DOI 10.1016/J.BBRC.2012.12.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gwf RNF41 structure of a usp8-nrdp1 complex 2.3Å AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,F.MACKENZIE,AUTH 2 E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESE INTERACTION,TITL 2 AND INHIBITED CATALYTIC DOMAIN CONFORMATION OF THETITL 3 UBIQUITIN-SPECIFIC PROTEASE 8 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2gi7 GP6 crystal structure of human platelet glycoprotein vi (gpvi) 2.4Å AUTH K.HORII,M.L.KAHN,A.B.HERRTITL STRUCTURAL BASIS FOR PLATELET COLLAGEN RESPONSES BY THETITL 2 IMMUNE-TYPE RECEPTOR GLYCOPROTEIN VI.REF BLOOD V. 108 936 2006REFN ISSN 0006-4971PMID 16861347DOI 10.1182/BLOOD-2006-01-010215 Variant Set Distributions Mapped Variants
General Structure Information 4kt1 LGR4 complex of r-spondin 1 with lgr4 extracellular domain 2.5Å AUTH D.L.WANG,B.HUANG,S.ZHANG,X.YU,W.WU,X.Q.WANGTITL STRUCTURAL BASIS FOR R-SPONDIN RECOGNITION BY LGR4/5/6TITL 2 RECEPTORSREF GENES DEV. V. 27 1339 2013REFN ISSN 0890-9369PMID 23756652DOI 10.1101/GAD.219360.113 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hai PACSIN1 crystal structure of human pacsin1 f-bar domain (p21 lattice) 2.88Å AUTH Q.WANG,M.V.NAVARRO,G.PENG,E.MOLINELLI,S.LIN GOH,AUTH 2 B.L.JUDSON,K.R.RAJASHANKAR,H.SONDERMANNTITL MOLECULAR MECHANISM OF MEMBRANE CONSTRICTION ANDTITL 2 TUBULATION MEDIATED BY THE F-BAR PROTEINTITL 3 PACSIN/SYNDAPIN.REF PROC.NATL.ACAD.SCI.USA V. 106 12700 2009REFN ISSN 0027-8424PMID 19549836DOI 10.1073/PNAS.0902974106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2ex4 NTMT1 crystal structure of human methyltransferase ad-003 in complex with s-adenosyl-l-homocysteine 1.75Å AUTH J.MIN,H.WU,H.ZENG,P.LOPPNAU,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN AD-003 PROTEIN INTITL 2 COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yra SEZ6L solution structure of the zinc finger domains (1-87) from human f-box only protein -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZINC FINGER DOMAINSTITL 2 (1-87) FROM HUMAN F-BOX ONLY PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mop MYD88 the ternary death domain complex of myd88, irak4, and irak2 3.4Å AUTH S.C.LIN,Y.C.LO,H.WUTITL HELICAL ASSEMBLY IN THE MYD88-IRAK4-IRAK2 COMPLEX INTITL 2 TLR/IL-1R SIGNALLING.REF NATURE V. 465 885 2010REFN ISSN 0028-0836PMID 20485341DOI 10.1038/NATURE09121 Variant Set Distributions Mapped Variants