Assessment of Structural Intolerance and Durability
General Structure Information 3l46 ECT2 crystal structure of the second brct domain of epithelial cell transforming 2 (ect2) 1.48Å AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,L.CROMBET,H.WANG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE SECOND BRCT DOMAIN OF EPITHELIALTITL 2 CELL TRANSFORMING 2 (ECT2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2hz5 DYNLRB1 crystal structure of human dynein light chain dnlc2a 2.1Å AUTH J.-F.LIU,Z.-X.WANG,X.-Q.WANG,Q.TANG,X.-M.AN,L.-L.GUI,AUTH 2 D.-C.LIANGTITL CRYSTAL STRUCTURE OF HUMAN DYNEIN LIGHT CHAIN DNLC2A:TITL 2 STRUCTURAL INSIGHTS INTO THE INTERACTION WITH IC74REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 349 1125 2006REFN ISSN 0006-291XPMID 16970917DOI 10.1016/J.BBRC.2006.08.161 Variant Set Distributions Mapped Variants
General Structure Information 3pyc SMURF1 crystal structure of human smurf1 c2 domain 1.96Å AUTH X.LI,P.LITITL CRYSTAL STRUCTURE OF HUMAN SMURF1 C2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3mqm ASH1L crystal structure of the bromodomain of human ash1l 2.54Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 1upq PLEKHA4 crystal structure of the pleckstrin homology (ph) domain of pepp1 1.48Å AUTH C.C.MILBURN,D.KOMANDER,M.DEAK,D.R.ALESSI,AUTH 2 D.M.F.VAN AALTENTITL CRYSTAL STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF PEPP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4lg6 ANKRA2 crystal structure of ankra2-ccdc8 complex 1.8Å AUTH J.NIE,C.XU,J.JIN,J.A.AKA,W.TEMPEL,V.NGUYEN,L.YOU,R.WEIST,AUTH 2 J.MIN,T.PAWSON,X.J.YANGTITL ANKYRIN REPEATS OF ANKRA2 RECOGNIZE A PXLPXL MOTIF ON THE 3MTITL 2 SYNDROME PROTEIN CCDC8.REF STRUCTURE V. 23 700 2015REFN ISSN 0969-2126PMID 25752541DOI 10.1016/J.STR.2015.02.001 Variant Set Distributions Mapped Variants
General Structure Information 2ab1 AAMDC x-ray structure of gene product from homo sapiens hs.95870 2.59Å AUTH CENTER FOR EUKARYOTIC STRUCTURAL GENOMICS (CESG)TITL X-RAY STRUCTURE OF GENE PRODUCT FROM HOMO SAPIENS HS.95870REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ote THG1L crystal structure of human trnahis guanylyltransferase (thg1)- native i 2.56Å AUTH S.J.HYDE,B.E.ECKENROTH,B.A.SMITH,W.A.EBERLEY,N.H.HEINTZ,AUTH 2 J.E.JACKMAN,S.DOUBLIETITL TRNAHIS GUANYLYLTRANSFERASE (THG1), A UNIQUE 3-5TITL 2 NUCLEOTIDYL TRANSFERASE, SHARES UNEXPECTED STRUCTURALTITL 3 HOMOLOGY WITH CANONICAL 5-3 DNA POLYMERASES.REF PROC.NATL.ACAD.SCI.USA V. 107 20305 2010REFN ISSN 0027-8424PMID 21059936DOI 10.1073/PNAS.1010436107 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4dhx ENY2 eny2:ganp complex 2.1Å AUTH D.JANI,S.LUTZ,E.HURT,R.A.LASKEY,M.STEWART,V.O.WICKRAMASINGHETITL FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF THE MAMMALIANTITL 2 TREX-2 COMPLEX THAT LINKS TRANSCRIPTION WITH NUCLEARTITL 3 MESSENGER RNA EXPORT.REF NUCLEIC ACIDS RES. V. 40 4562 2012REFN ISSN 0305-1048PMID 22307388DOI 10.1093/NAR/GKS059 Variant Set Distributions Mapped Variants
General Structure Information 2ohf OLA1 crystal structure of human ola1 in complex with amppcp 2.7Å AUTH R.KOLLER-EICHHORN,T.MARQUARDT,R.GAIL,A.WITTINGHOFER,AUTH 2 D.KOSTREWA,U.KUTAY,C.KAMBACHTITL HUMAN OLA1 DEFINES AN ATPASE SUBFAMILY IN THE OBG FAMILY OFTITL 2 GTP-BINDING PROTEINSREF J.BIOL.CHEM. V. 282 19928 2007REFN ISSN 0021-9258PMID 17430889DOI 10.1074/JBC.M700541200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants