Assessment of Structural Intolerance and Durability
General Structure Information 3e0j POLD3 x-ray structure of the complex of regulatory subunits of human dna polymerase delta 3.0Å AUTH A.G.BARANOVSKIY,N.D.BABAYEVA,V.G.LISTON,AUTH 2 I.B.ROGOZIN,E.V.KOONIN,Y.I.PAVLOV,D.G.VASSYLYEV,AUTH 3 T.H.TAHIROVTITL X-RAY STRUCTURE OF THE COMPLEX OF REGULATORYTITL 2 SUBUNITS OF HUMAN DNA POLYMERASE DELTA.REF CELL CYCLE V. 7 3026 2008REFN ISSN 1538-4101PMID 18818516 Variant Set Distributions Mapped Variants
General Structure Information 2q8h PDK1 structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (dca) 2.0Å AUTH M.KATO,J.LI,J.L.CHUANG,D.T.CHUANGTITL DISTINCT STRUCTURAL MECHANISMS FOR INHIBITION OF PYRUVATETITL 2 DEHYDROGENASE KINASE ISOFORMS BY AZD7545, DICHLOROACETATE,TITL 3 AND RADICICOL.REF STRUCTURE V. 15 992 2007REFN ISSN 0969-2126PMID 17683942DOI 10.1016/J.STR.2007.07.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4o2w HERC1 crystal structure of the third rcc1-like domain of herc1 2.0Å AUTH J.HU,A.DONG,Y.LI,J.R.WALKER,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,Y.TONG,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE THIRD RCC1-LIKE DOMAIN OF HERC1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2d07 TDG crystal structure of sumo-3-modified thymine-dna glycosylase 2.1Å AUTH D.BABA,N.MAITA,J.G.JEE,Y.UCHIMURA,H.SAITOH,AUTH 2 K.SUGASAWA,F.HANAOKA,H.TOCHIO,H.HIROAKI,M.SHIRAKAWATITL CRYSTAL STRUCTURE OF SUMO-3-MODIFIED THYMINE-DNATITL 2 GLYCOSYLASEREF J.MOL.BIOL. V. 359 137 2006REFN ISSN 0022-2836PMID 16626738DOI 10.1016/J.JMB.2006.03.036 Variant Set Distributions Mapped Variants
General Structure Information 1wgm UBE4A solution structure of the u-box in human ubiquitin conjugation factor e4a -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE U-BOX IN HUMAN UBIQUITINTITL 2 CONJUGATION FACTOR E4AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wgm UBE4A solution structure of the u-box in human ubiquitin conjugation factor e4a -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE U-BOX IN HUMAN UBIQUITINTITL 2 CONJUGATION FACTOR E4AREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2hlq BMPR2 crystal structure of the extracellular domain of the type ii bmp receptor 1.45Å AUTH P.D.MACE,J.F.CUTFIELD,S.M.CUTFIELDTITL HIGH RESOLUTION STRUCTURES OF THE BONETITL 2 MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN TWOTITL 3 CRYSTAL FORMS: IMPLICATIONS FOR LIGAND BINDINGREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 351 831 2006REFN ISSN 0006-291XPMID 17094948DOI 10.1016/J.BBRC.2006.10.109 Variant Set Distributions Mapped Variants
General Structure Information 3pe0 PLEC structure of the central region of the plakin domain of plectin 2.95Å AUTH E.ORTEGA,R.M.BUEY,A.SONNENBERG,J.M.DE PEREDATITL THE STRUCTURE OF THE PLAKIN DOMAIN OF PLECTIN REVEALS ATITL 2 NON-CANONICAL SH3 DOMAIN INTERACTING WITH ITS FOURTHTITL 3 SPECTRIN REPEAT.REF J.BIOL.CHEM. V. 286 12429 2011REFN ISSN 0021-9258PMID 21288893DOI 10.1074/JBC.M110.197467 Variant Set Distributions Ripley’s K […]
General Structure Information 1wyr ARHGEF6 solution structure of the ch domain of human rho guanine nucleotide exchange factor 6 -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN OF HUMAN RHOTITL 2 GUANINE NUCLEOTIDE EXCHANGE FACTOR 6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2c5d GAS6 structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants