Assessment of Structural Intolerance and Durability
General Structure Information 2vyt SCML2 the mbt repeats of human scml2 bind to peptides containing mono methylated lysine. 1.9Å AUTH C.M.SANTIVERI,B.C.LECHTENBERG,M.D.ALLEN,AUTH 2 A.SATHYAMURTHY,A.M.JAULENT,S.M.V.FREUND,M.BYCROFTTITL THE MALIGNANT BRAIN TUMOR REPEATS OF HUMAN SCML2TITL 2 BIND TO PEPTIDES CONTAINING MONOMETHYLATED LYSINE.REF J.MOL.BIOL. V. 382 1107 2008REFN ISSN 0022-2836PMID 18706910DOI 10.1016/J.JMB.2008.07.081 Variant Set Distributions Mapped Variants
General Structure Information 4bzc SAMHD1 crystal structure of the tetrameric dgtp-bound wild type samhd1 catalytic core 2.88Å AUTH X.JI,Y.WU,J.YAN,J.MEHRENS,H.YANG,M.DELUCIA,C.HAO,AUTH 2 A.M.GRONENBORN,J.SKOWRONSKI,J.AHN,Y.XIONGTITL MECHANISM OF ALLOSTERIC ACTIVATION OF SAMHD1 BY DGTPREF NAT.STRUCT.MOL.BIOL. V. 20 1304 2013REFN ISSN 1545-9993PMID 24141705DOI 10.1038/NSMB.2692 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3qor NUDC crystal structure of human nuclear migration protein nudc 1.75Å AUTH M.ZHENG,T.CIERPICKI,A.J.BURDETTE,D.UTEPBERGENOV,P.L.JANCZYK,AUTH 2 U.DEREWENDA,P.T.STUKENBERG,K.A.CALDWELL,Z.S.DEREWENDATITL STRUCTURAL FEATURES AND CHAPERONE ACTIVITY OF THE NUDCTITL 2 PROTEIN FAMILY.REF J.MOL.BIOL. V. 409 722 2011REFN ISSN 0022-2836PMID 21530541DOI 10.1016/J.JMB.2011.04.018 Variant Set Distributions Mapped Variants
General Structure Information 4hlj ROBO1 axon guidance receptor 1.8Å AUTH R.BARAK,Y.OPATOWSKYTITL CRYSTAL STRUCTURE OF AXON GUIDANCE RECEPTORREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lq3 CHKB crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide 1.42Å AUTH B.S.HONG,A.ALLALI-HASSANI,W.TEMPEL,P.J.FINERTY,F.MACKENZIE,AUTH 2 S.DIMOV,M.VEDADI,H.W.PARKTITL CRYSTAL STRUCTURES OF HUMAN CHOLINE KINASE ISOFORMS INTITL 2 COMPLEX WITH HEMICHOLINIUM-3: SINGLE AMINO ACID NEAR THETITL 3 ACTIVE SITE INFLUENCES INHIBITOR SENSITIVITY.REF J.BIOL.CHEM. V. 285 16330 2010REFN ISSN 0021-9258PMID […]
General Structure Information 2d2z CLIC4 crystal structure of soluble form of clic4 2.2Å AUTH Y.F.LI,D.F.LI,Z.H.ZENG,D.C.WANGTITL TRIMERIC STRUCTURE OF THE WILD SOLUBLE CHLORIDETITL 2 INTRACELLULAR ION CHANNEL CLIC4 OBSERVED INTITL 3 CRYSTALSREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 343 1272 2006REFN ISSN 0006-291XPMID 16581025DOI 10.1016/J.BBRC.2006.03.099 Variant Set Distributions Mapped Variants
General Structure Information 3e0l GDA computationally designed ammelide deaminase 2.37Å AUTH P.M.MURPHY,J.M.BOLDUC,J.L.GALLAHER,B.L.STODDARD,AUTH 2 D.BAKERTITL ALTERATION OF ENZYME SPECIFICITY BY COMPUTATIONALTITL 2 LOOP REMODELING AND DESIGN.REF PROC.NATL.ACAD.SCI.USA V. 106 9215 2009REFN ISSN 0027-8424PMID 19470646DOI 10.1073/PNAS.0811070106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vpd PYGO1 decoding of methylated histone h3 tail by the pygo-bcl9 wnt signaling complex 2.77Å AUTH M.FIEDLER,M.J.SANCHEZ-BARRENA,M.NEKRASOV,AUTH 2 J.MIESZCZANEK,V.RYBIN,J.MULLER,P.EVANS,M.BIENZTITL DECODING OF METHYLATED HISTONE H3 TAIL BY THETITL 2 PYGO- BCL9 WNT SIGNALING COMPLEX.REF MOL.CELL V. 30 507 2008REFN ISSN 1097-2765PMID 18498752DOI 10.1016/J.MOLCEL.2008.03.011 Variant Set Distributions Mapped Variants
General Structure Information 2z6e DAAM1 crystal structure of human daam1 fh2 2.8Å AUTH M.YAMASHITA,T.HIGASHI,S.SUETSUGU,Y.SATO,T.IKEDA,AUTH 2 R.SHIRAKAWA,T.KITA,T.TAKENAWA,H.HORIUCHI,S.FUKAI,AUTH 3 O.NUREKITITL CRYSTAL STRUCTURE OF HUMAN DAAM1 FORMIN HOMOLOGY 2TITL 2 DOMAINREF GENES CELLS V. 12 1255 2007REFN ISSN 1356-9597PMID 17986009DOI 10.1111/J.1365-2443.2007.01132.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1inz EPN1 solution structure of the epsin n-terminal homology (enth) domain of human epsin -1.0Å AUTH S.KOSHIBA,T.KIGAWA,A.KIKUCHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE EPSIN N-TERMINALTITL 2 HOMOLOGY (ENTH) DOMAIN OF HUMAN EPSINREF J.STRUCT.FUNCT.GENOM. V. 2 1 2001REFN ISSN 1345-711XPMID 12836669DOI 10.1023/A:1011397007366 Variant Set Distributions Mapped Variants