Assessment of Structural Intolerance and Durability
General Structure Information 4g2v FRMPD1 structure complex of lgn binding with frmpd1 2.4Å AUTH Z.PAN,Y.SHANG,M.JIA,L.ZHANG,C.XIA,M.ZHANG,W.WANG,W.WENTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THETITL 2 INTERACTION BETWEEN LGN AND FRMPD1REF J.MOL.BIOL. V. 425 1039 2013REFN ISSN 0022-2836PMID 23318951DOI 10.1016/J.JMB.2013.01.003 Variant Set Distributions Mapped Variants
General Structure Information 2i6l MAPK6 crystal structure of human mitogen activated protein kinase 6 (mapk6) 2.25Å AUTH P.FILIPPAKOPOULOS,A.P.TURNBULL,P.SAVITSKY,AUTH 2 O.FEDOROV,G.BERRIDGE,S.DAS,J.ELKINS,AUTH 3 M.SOUNDARARAJAN,X.W.YANG,D.DOYLE,E.PAPAGRIGORIOU,AUTH 4 A.C.W.PIKE,G.BUNKONCZI,E.UGOCHUKWU,J.DEBRECZENI,AUTH 5 F.VON DELFT,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 6 S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN MITOGEN ACTIVATEDTITL 2 PROTEIN KINASE 6REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1hzm DUSP6 structure of erk2 binding domain of mapk phosphatase mkp-3: structural insights into mkp-3 activation by erk2 -1.0Å AUTH A.FAROOQ,G.CHATURVEDI,S.MUJTABA,O.PLOTNIKOVA,AUTH 2 L.ZENG,C.DHALLUIN,R.ASHTON,M.M.ZHOUTITL SOLUTION STRUCTURE OF ERK2 BINDING DOMAIN OF MAPKTITL 2 PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3TITL 3 ACTIVATION BY ERK2.REF MOL.CELL V. 7 387 2001REFN ISSN 1097-2765PMID 11239467DOI 10.1016/S1097-2765(01)00186-1 Variant […]
General Structure Information 2f9m RAB11B 3d structure of active human rab11b gtpase 1.95Å AUTH S.M.SCAPIN,F.R.CARNEIRO,A.C.ALVES,F.J.MEDRANO,AUTH 2 B.G.GUIMARAES,N.I.ZANCHINTITL THE CRYSTAL STRUCTURE OF THE SMALL GTPASE RAB11BTITL 2 REVEALS CRITICAL DIFFERENCES RELATIVE TO THETITL 3 RAB11A ISOFORM.REF J.STRUCT.BIOL. V. 154 260 2006REFN ISSN 1047-8477PMID 16545962DOI 10.1016/J.JSB.2006.01.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2ekh SH3PXD2A solution structures of the sh3 domain of human kiaa0418 -1.0Å AUTH M.SATO,N.TOCHIO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SH3 DOMAIN OF HUMANTITL 2 KIAA0418REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yqp DDX59 solution structure of the zf-hit domain in dead (asp-glu- ala-asp) box polypeptide 59 -1.0Å AUTH F.HE,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TARADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZF-HIT DOMAIN IN DEADTITL 2 (ASP-GLU-ALA-ASP) BOX POLYPEPTIDE 59REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2enk SLC30A9 solution structure of a putativ dna-binding domain of the humansolute carrier family 30 (zinc transporter) protein -1.0Å AUTH A.K.GORONCY,N.TOCHIO,T.TOMIZAWA,S.KOSHIBA,AUTH 2 S.WATANABE,T.HARADA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF A PUTATIV DNA-BINDING DOMAINTITL 2 OF THE HUMANSOLUTE CARRIER FAMILY 30 (ZINCTITL 3 TRANSPORTER) PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4abl PARP14 human parp14 (artd8, bal2) – macro domain 3 1.15Å AUTH A.H.FORST,T.KARLBERG,N.HERZOG,A.G.THORSELL,A.GROSS,AUTH 2 K.L.H.FEIJS,P.VERHEUGD,P.KURSULA,B.NIJMEIJER,E.KREMMER,AUTH 3 H.KLEINE,A.G.LADURNER,H.SCHULER,B.LUSCHERTITL RECOGNITION OF MONO-ADP-RIBOSYLATED ARTD10 SUBSTRATES BYTITL 2 ARTD8 MACRODOMAINSREF STRUCTURE V. 21 462 2013REFN ISSN 0969-2126PMID 23473667DOI 10.1016/J.STR.2012.12.019 Variant Set Distributions Mapped Variants
General Structure Information 2iag PTGIS crystal structure of human prostacyclin synthase 2.15Å AUTH C.-W.CHIANG,H.-C.YEH,L.-H.WANG,N.-L.CHANTITL CRYSTAL STRUCTURE OF THE HUMAN PROSTACYCLINTITL 2 SYNTHASEREF J.MOL.BIOL. V. 364 266 2006REFN ISSN 0022-2836PMID 17020766DOI 10.1016/J.JMB.2006.09.039 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3u21 NFRKB crystal structure of a fragment of nuclear factor related to kappa-b- binding protein (residues 370-495) (nfrkb) from homo sapiens at 2.18 a resolution 2.18Å AUTH A.KUMAR,S.MOCKLINGHOFF,F.YUMOTO,L.JAROSZEWSKI,C.L.FARR,AUTH 2 A.GRZECHNIK,P.NGUYEN,C.X.WEICHENBERGER,H.J.CHIU,H.E.KLOCK,AUTH 3 M.A.ELSLIGER,A.M.DEACON,A.GODZIK,S.A.LESLEY,B.R.CONKLIN,AUTH 4 R.J.FLETTERICK,I.A.WILSONTITL STRUCTURE OF A NOVEL WINGED-HELIX LIKE DOMAIN FROM HUMANTITL 2 NFRKB PROTEIN.REF PLOS ONE V. 7 43761 2012REFN […]