Assessment of Structural Intolerance and Durability
General Structure Information 2lgx FERMT2 nmr structure for kindle-2 n-terminus -1.0Å AUTH H.D.PERERA,Y.Q.MA,J.YANG,J.HIRBAWI,E.F.PLOW,J.QINTITL MEMBRANE BINDING OF THE N-TERMINAL UBIQUITIN-LIKE DOMAIN OFTITL 2 KINDLIN-2 IS CRUCIAL FOR ITS REGULATION OF INTEGRINTITL 3 ACTIVATION.REF STRUCTURE V. 19 1664 2011REFN ISSN 0969-2126PMID 22078565DOI 10.1016/J.STR.2011.08.012 Variant Set Distributions Mapped Variants
General Structure Information 1l2j ESR2 human estrogen receptor beta ligand-binding domain in complex with (r, r)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol 2.95Å AUTH A.K.SHIAU,D.BARSTAD,J.T.RADEK,M.J.MEYERS,K.W.NETTLES,AUTH 2 B.S.KATZENELLENBOGEN,J.A.KATZENELLENBOGEN,D.A.AGARD,AUTH 3 G.L.GREENETITL STRUCTURAL CHARACTERIZATION OF A SUBTYPE-SELECTIVE LIGANDTITL 2 REVEALS A NOVEL MODE OF ESTROGEN RECEPTOR ANTAGONISM.REF NAT.STRUCT.BIOL. V. 9 359 2002REFN ISSN 1072-8368PMID 11953755 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3d3k EDC3 crystal structure of human edc3p 2.2Å AUTH S.H.M.LING,C.J.DECKER,M.A.WALSH,M.SHE,R.PARKER,H.SONGTITL CRYSTAL STRUCTURE OF HUMAN EDC3 AND ITS FUNCTIONALTITL 2 IMPLICATIONSREF MOL.CELL.BIOL. V. 28 5965 2008REFN ISSN 0270-7306PMID 18678652DOI 10.1128/MCB.00761-08 Variant Set Distributions Mapped Variants
General Structure Information 4nsq KAT2B crystal structure of pcaf 2.31Å AUTH S.SHI,J.LIN,Y.CAI,J.YU,H.HONG,K.JI,J.S.DOWNEY,X.LU,R.CHEN,AUTH 2 J.HAN,A.HANTITL DIMERIC STRUCTURE OF P300/CBP ASSOCIATED FACTOR.REF BMC STRUCT.BIOL. V. 14 2 2014REFN ESSN 1472-6807PMID 24423233DOI 10.1186/1472-6807-14-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2eaq LMO7 crystal structure of pdz domain of kiaa0858 (lim), ms0793 from homo sapiens 1.46Å AUTH Y.XIE,S.KISHISHITA,K.MURAYAMA,C.TAKEMOTO,M.SHIROZU,AUTH 2 S.YOKOYAMATITL CRYSTAL STRUCTURE OF PDZ DOMAIN OF KIAA0858 (LIM),TITL 2 MS0793 FROM HOMO SAPIENSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2a7l UBE2W structure of the human hypothetical ubiquitin-conjugating enzyme, loc55284 1.82Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 4hc4 PRMT6 human hmt1 hnrnp methyltransferase-like protein 6 (s. cerevisiae) 1.97Å AUTH H.ZENG,A.DONG,H.HE,M.EL BAKKOURI,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,H.WUTITL THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNPTITL 2 METHYLTRANSFERASE-LIKE PROTEIN 6 IN COMPLEX WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2a5j RAB2B crystal structure of human rab2b 1.5Å AUTH J.WANG,A.DONG,Y.SHEN,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,A.BOCHKAREV,H.W.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB2BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2yus SMARCC1 solution structure of the sant domain of human swi/snf- related matrix-associated actin-dependent regulator of chromatin subfamily c member 1 -1.0Å AUTH N.TOCHIO,S.KOSHIBA,K.SATIO,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SANT DOMAIN OF HUMANTITL 2 SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENTTITL 3 REGULATOR OF CHROMATIN SUBFAMILY C MEMBER 1REF TO BE PUBLISHEDREFN Variant Set Distributions […]
General Structure Information 1z4r KAT2A human gcn5 acetyltransferase 1.74Å AUTH A.SCHUETZ,G.BERNSTEIN,A.DONG,T.ANTOSHENKO,H.WU,AUTH 2 P.LOPPNAU,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF A BINARY COMPLEX BETWEENTITL 2 HUMAN GCN5 HISTONE ACETYLTRANSFERASE DOMAIN ANDTITL 3 ACETYL COENZYME AREF PROTEINS V. 68 403 2007REFN ISSN 0887-3585PMID 17410582DOI 10.1002/PROT.21407 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants