Assessment of Structural Intolerance and Durability
General Structure Information 2atv RERG the crystal structure of human rerg in the gdp bound state 1.9Å AUTH A.P.TURNBULL,E.SALAH,G.SCHOCH,J.ELKINS,N.BURGESS,O.GILEADI,AUTH 2 F.VON DELFT,J.WEIGELT,A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,AUTH 3 D.DOYLETITL THE CRYSTAL STRUCTURE OF HUMAN RERG IN THE GDP BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3f1i STAM human escrt-0 core complex 2.3Å AUTH X.REN,D.P.KLOER,Y.C.KIM,R.GHIRLANDO,L.F.SAIDI,G.HUMMER,AUTH 2 J.H.HURLEYTITL HYBRID STRUCTURAL MODEL OF THE COMPLETE HUMAN ESCRT-0TITL 2 COMPLEX.REF STRUCTURE V. 17 406 2009REFN ISSN 0969-2126PMID 19278655DOI 10.1016/J.STR.2009.01.012 Variant Set Distributions Mapped Variants
General Structure Information 1so0 GALM crystal structure of human galactose mutarotase complexed with galactose 2.3Å AUTH J.B.THODEN,D.J.TIMSON,R.J.REECE,H.M.HOLDENTITL MOLECULAR STRUCTURE OF HUMAN GALACTOSE MUTAROTASEREF J.BIOL.CHEM. V. 279 23431 2004REFN ISSN 0021-9258PMID 15026423DOI 10.1074/JBC.M402347200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1x6f ZNF462 solution structures of the c2h2 type zinc finger domain of human zinc finger protein 462 -1.0Å AUTH M.SATO,K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURES OF THE C2H2 TYPE ZINC FINGERTITL 2 DOMAIN OF HUMAN ZINC FINGER PROTEIN 462REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2eax PGLYRP4 crystal structure of human pgrp-ibetac in complex with glycosamyl muramyl pentapeptide 2.1Å AUTH S.CHO,Q.WANG,C.P.SWAMINATHAN,D.HESEK,M.LEE,G.J.BOONS,AUTH 2 S.MOBASHERY,R.A.MARIUZZATITL STRUCTURAL INSIGHTS INTO THE BACTERICIDAL MECHANISM OF HUMANTITL 2 PEPTIDOGLYCAN RECOGNITION PROTEINSREF PROC.NATL.ACAD.SCI.USA V. 104 8761 2007REFN ISSN 0027-8424PMID 17502600DOI 10.1073/PNAS.0701453104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1shz ARHGEF1 crystal structure of the p115rhogef rgrgs domain in a complex with galpha(13):galpha(i1) chimera 2.85Å AUTH Z.CHEN,W.D.SINGER,P.C.STERNWEIS,S.R.SPRANGTITL STRUCTURE OF THE P115RHOGEF RGRGSTITL 2 DOMAIN-GALPHA13/I1 CHIMERA COMPLEX SUGGESTSTITL 3 CONVERGENT EVOLUTION OF A GTPASE ACTIVATOR.REF NAT.STRUCT.MOL.BIOL. V. 12 191 2005REFN ISSN 1545-9993PMID 15665872DOI 10.1038/NSMB888 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2rnx KAT2B the structural basis for site-specific lysine-acetylated histone recognition by the bromodomains of the human transcriptional co-activators pcaf and cbp -1.0Å AUTH L.ZENG,Q.ZHANG,G.GERONA-NAVARRO,N.MOSHKINA,M.M.ZHOUTITL STRUCTURAL BASIS OF SITE-SPECIFIC HISTONETITL 2 RECOGNITION BY THE BROMODOMAINS OF HUMANTITL 3 COACTIVATORS PCAF AND CBP/P300REF STRUCTURE V. 16 643 2008REFN ISSN 0969-2126PMID 18400184DOI 10.1016/J.STR.2008.01.010 Variant Set […]
General Structure Information 2m17 UBLCP1 ubiquitin-like domain-containing c-terminal domain phosphatase (ublcp1) -1.0Å AUTH J.H.YUN,S.KO,C.K.LEE,H.K.CHEONG,C.CHEONG,J.B.YOON,W.LEETITL SOLUTION STRUCTURE AND RPN1 INTERACTION OF THE UBL DOMAIN OFTITL 2 HUMAN RNA POLYMERASE II C-TERMINAL DOMAIN PHOSPHATASE.REF PLOS ONE V. 8 62981 2013REFN ESSN 1932-6203PMID 23667555DOI 10.1371/JOURNAL.PONE.0062981 Variant Set Distributions Mapped Variants
General Structure Information 1wf6 TOPBP1 the third brca1 c-terminus (brct) domain of similar to s.pombe rad4+/cut5+ product -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL THE THIRD BRCA1 C-TERMINUS (BRCT) DOMAIN OFTITL 2 SIMILAR TO S.POMBE RAD4+/CUT5+ PRODUCTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2idx MMAB structure of human atp:cobalamin adenosyltransferase bound to atp. 2.5Å AUTH H.L.SCHUBERT,C.P.HILLTITL STRUCTURE OF ATP-BOUND HUMAN ATP:COBALAMINTITL 2 ADENOSYLTRANSFERASE.REF BIOCHEMISTRY V. 45 15188 2006REFN ISSN 0006-2960PMID 17176040DOI 10.1021/BI061396F Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants