Assessment of Structural Intolerance and Durability
General Structure Information 2w8r ALDH5A1 the crystal structure of human ssadh in complex with nad+ 2.4Å AUTH Y.-G.KIM,S.LEE,O.-S.KWON,S.-Y.PARK,S.-J.LEE,AUTH 2 B.-J.PARK,K.-J.KIMTITL REDOX-SWITCH MODULATION OF HUMAN SSADH BY DYNAMICTITL 2 CATALYTIC LOOP.REF EMBO J. V. 28 959 2009REFN ISSN 0261-4189PMID 19300440DOI 10.1038/EMBOJ.2009.40 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fby COMP the crystal structure of the signature domain of cartilage oligomeric matrix protein. 3.15Å AUTH K.TAN,M.DUQUETTE,A.JOACHIMIAK,J.LAWLERTITL THE CRYSTAL STRUCTURE OF THE SIGNATURE DOMAIN OF CARTILAGETITL 2 OLIGOMERIC MATRIX PROTEIN: IMPLICATIONS FOR COLLAGEN,TITL 3 GLYCOSAMINOGLYCAN AND INTEGRIN BINDING.REF FASEB J. V. 23 2490 2009REFN ISSN 0892-6638PMID 19276170DOI 10.1096/FJ.08-128090 Variant Set Distributions Ripley’s […]
General Structure Information 2vxo GMPS human gmp synthetase in complex with xmp 2.5Å AUTH M.WELIN,L.LEHTIO,A.JOHANSSON,S.FLODIN,T.NYMAN,AUTH 2 L.TRESAUGUES,M.HAMMARSTROM,S.GRASLUND,P.NORDLUNDTITL SUBSTRATE SPECIFICITY AND OLIGOMERIZATION OF HUMANTITL 2 GMP SYNTHETASEREF J.MOL.BIOL. V. 425 4323 2013REFN ISSN 0022-2836PMID 23816837DOI 10.1016/J.JMB.2013.06.032 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2rr8 IQGAP1 solution structure of calponin homology domain of iqgap1 -1.0Å AUTH R.UMEMOTO,N.NISHIDA,S.OGINO,I.SHIMADATITL NMR STRUCTURE OF THE CALPONIN HOMOLOGY DOMAIN OF HUMANTITL 2 IQGAP1 AND ITS IMPLICATIONS FOR THE ACTIN RECOGNITION MODE.REF J.BIOMOL.NMR V. 48 59 2010REFN ISSN 0925-2738PMID 20644981DOI 10.1007/S10858-010-9434-8 Variant Set Distributions Mapped Variants
General Structure Information 1qk9 MECP2 the solution structure of the domain from mecp2 that binds to methylated dna -1.0Å AUTH R.I.D.WAKEFIELD,B.O.SMITH,X.NAN,A.FREE,A.SOTERIOU,AUTH 2 D.UHRIN,A.P.BIRD,P.N.BARLOWTITL THE SOLUTION STRUCTURE OF THE DOMAIN FROM MECP2TITL 2 THAT BINDS TO METHYLATED DNAREF J.MOL.BIOL. V. 291 1055 1999REFN ISSN 0022-2836 70PMID 10518942DOI 10.1006/JMBI.1999.3023 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1bqq MMP14 crystal structure of the mt1-mmp–timp-2 complex 2.75Å AUTH C.FERNANDEZ-CATALAN,W.BODE,R.HUBER,D.TURK,AUTH 2 J.J.CALVETE,A.LICHTE,H.TSCHESCHE,K.MASKOSTITL CRYSTAL STRUCTURE OF THE COMPLEX FORMED BY THETITL 2 MEMBRANE TYPE 1-MATRIX METALLOPROTEINASE WITH THETITL 3 TISSUE INHIBITOR OF METALLOPROTEINASES-2, THETITL 4 SOLUBLE PROGELATINASE A RECEPTOR.REF EMBO J. V. 17 5238 1998REFN ISSN 0261-4189PMID 9724659DOI 10.1093/EMBOJ/17.17.5238 Variant Set Distributions […]
General Structure Information 3nbn NOTCH1 crystal structure of a dimer of notch transcription complex trimers on hes1 dna 3.45Å AUTH K.L.ARNETT,M.HASS,D.G.MCARTHUR,M.X.ILAGAN,J.C.ASTER,R.KOPAN,AUTH 2 S.C.BLACKLOWTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO COOPERATIVETITL 2 ASSEMBLY OF DIMERIC NOTCH TRANSCRIPTION COMPLEXES.REF NAT.STRUCT.MOL.BIOL. V. 17 1312 2010REFN ISSN 1545-9993PMID 20972443DOI 10.1038/NSMB.1938 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3fay IQGAP1 crystal structure of the gap-related domain of iqgap1 2.2Å AUTH V.B.KURELLA,J.M.RICHARD,C.L.PARKE,L.F.LECOUR,AUTH 2 H.D.BELLAMY,D.K.WORTHYLAKETITL CRYSTAL STRUCTURE OF THE GTPASE-ACTIVATINGTITL 2 PROTEIN-RELATED DOMAIN FROM IQGAP1.REF J.BIOL.CHEM. V. 284 14857 2009REFN ISSN 0021-9258PMID 19321438DOI 10.1074/JBC.M808974200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4m4r EPHA4 epha4 ectodomain complex with ephrin a5 3.13Å AUTH K.XU,D.TZVETKOVA-ROBEV,Y.XU,Y.GOLDGUR,Y.P.CHAN,J.P.HIMANEN,AUTH 2 D.B.NIKOLOVTITL INSIGHTS INTO EPH RECEPTOR TYROSINE KINASE ACTIVATION FROMTITL 2 CRYSTAL STRUCTURES OF THE EPHA4 ECTODOMAIN AND ITS COMPLEXTITL 3 WITH EPHRIN-A5.REF PROC.NATL.ACAD.SCI.USA V. 110 14634 2013REFN ISSN 0027-8424PMID 23959867DOI 10.1073/PNAS.1311000110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4go6 HCFC1 crystal structure of hcf-1 self-association sequence 1 2.7Å AUTH J.PARK,F.LAMMERS,W.HERR,J.SONGTITL HCF-1 SELF-ASSOCIATION VIA AN INTERDIGITATED FN3 STRUCTURETITL 2 FACILITATES TRANSCRIPTIONAL REGULATORY COMPLEX FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 109 17430 2012REFN ISSN 0027-8424PMID 23045687DOI 10.1073/PNAS.1208378109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants