Assessment of Structural Intolerance and Durability
General Structure Information 1fgg B3GAT3 crystal structure of 1,3-glucuronyltransferase i (glcat-i) complexed with gal-gal-xyl, udp, and mn2+ 2.3Å AUTH L.C.PEDERSEN,K.TSUCHIDA,H.KITAGAWA,K.SUGAHARA,AUTH 2 T.A.DARDEN,M.NEGISHITITL HEPARAN/CHONDROITIN SULFATE BIOSYNTHESIS.TITL 2 STRUCTURE AND MECHANISM OF HUMANTITL 3 GLUCURONYLTRANSFERASE I.REF J.BIOL.CHEM. V. 275 34580 2000REFN ISSN 0021-9258PMID 10946001DOI 10.1074/JBC.M007399200 Variant Set Distributions Mapped Variants
General Structure Information 1wrd TOM1 crystal structure of tom1 gat domain in complex with ubiquitin 1.75Å AUTH M.AKUTSU,M.KAWASAKI,Y.KATOH,T.SHIBA,Y.YAMAGUCHI,R.KATO,AUTH 2 K.KATO,K.NAKAYAMA,S.WAKATSUKITITL STRUCTURAL BASIS FOR RECOGNITION OF UBIQUITINATED CARGO BYTITL 2 TOM1-GAT DOMAIN.REF FEBS LETT. V. 579 5385 2005REFN ISSN 0014-5793PMID 16199040DOI 10.1016/J.FEBSLET.2005.08.076 Variant Set Distributions Mapped Variants
General Structure Information 3g65 HUS1 crystal structure of the human rad9-rad1-hus1 dna damage checkpoint complex 2.9Å AUTH A.S.DORE,M.L.KILKENNY,N.J.RZECHORZEK,L.H.PEARLTITL CRYSTAL STRUCTURE OF THE RAD9-RAD1-HUS1 DNA DAMAGETITL 2 CHECKPOINT COMPLEX–IMPLICATIONS FOR CLAMP LOADING ANDTITL 3 REGULATION.REF MOL.CELL V. 34 735 2009REFN ISSN 1097-2765PMID 19446481DOI 10.1016/J.MOLCEL.2009.04.027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2gf0 DIRAS1 the crystal structure of the human diras1 gtpase in the inactive gdp bound state 1.9Å AUTH A.P.TURNBULL,E.PAPAGRIGORIOU,X.YANG,G.SCHOCH,AUTH 2 J.ELKINS,O.GILEADI,E.SALAH,J.BRAY,L.WEN-HWA,AUTH 3 O.FEDOROV,F.E.NIESEN,F.VON DELFT,J.WEIGELT,AUTH 4 A.EDWARDS,C.ARROWSMITH,M.SUNDSTROM,D.DOYLETITL THE CRYSTAL STRUCTURE OF THE HUMAN DIRAS1 GTPASETITL 2 IN THE INACTIVE GDP BOUND STATEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3kuz PLXNC1 crystal structure of the ubiquitin like domain of plxnc1 2.3Å AUTH H.WANG,B.LI,W.TEMPEL,Y.TONG,X.GUAN,N.ZHONG,AUTH 2 L.CROMBET,F.MACKENZIE,M.BUCK,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE UBIQUITIN LIKE DOMAIN OFTITL 2 PLXNC1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1iyf PARK2 solution structure of ubiquitin-like domain of human parkin -1.0Å AUTH E.SAKATA,Y.YAMAGUCHI,E.KURIMOTO,J.KIKUCHI,AUTH 2 S.YOKOYAMA,S.YAMADA,H.KAWAHARA,H.YOKOSAWA,AUTH 3 N.HATTORI,Y.MIZUNO,K.TANAKA,K.KATOTITL PARKIN BINDS THE RPN10 SUBUNIT OF 26S PROTEASOMESTITL 2 THROUGH ITS UBIQUITIN-LIKE DOMAINREF EMBO REP. V. 4 301 2003REFN ISSN 1469-221XPMID 12634850DOI 10.1038/SJ.EMBOR.EMBOR764 Variant Set Distributions Mapped Variants
General Structure Information 3v6c USP2 crystal structure of usp2 in complex with mutated ubiquitin 1.7Å AUTH M.NECULAI,A.ERNST,S.SIDHU,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 C.BOUNTRA,J.WEIGELT,S.DHE-PAGANONTITL CRYSTAL STRUCTURE OF USP2 IN COMPLEX WITH MUTATED UBIQUITINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ecm PDE8A crystal structure of the unliganded pde8a catalytic domain 1.9Å AUTH H.WANG,Z.YAN,S.YANG,J.CAI,H.ROBINSON,H.KETITL KINETIC AND STRUCTURAL STUDIES OFTITL 2 PHOSPHODIESTERASE-8A AND IMPLICATION ON THETITL 3 INHIBITOR SELECTIVITYREF BIOCHEMISTRY V. 47 12760 2008REFN ISSN 0006-2960PMID 18983167DOI 10.1021/BI801487X Variant Set Distributions Mapped Variants
General Structure Information 2f15 PRKAB2 glycogen-binding domain of the amp-activated protein kinase beta2 subunit 2.0Å AUTH J.R.WALKER,L.WYBENGA-GROOT,P.J.FINERTY JR.,AUTH 2 E.NEWMAN,F.M.MACKENZIE,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.ARROWSMITH,A.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF THE GLYCOGEN-BINDING DOMAIN OF THETITL 2 AMP-ACTIVATED PROTEIN KINASE BETA2 SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3nby SNUPN crystal structure of the pki nes-crm1-rangtp nuclear export complex 3.42Å AUTH T.GUTTLER,T.MADL,P.NEUMANN,D.DEICHSEL,L.CORSINI,T.MONECKE,AUTH 2 R.FICNER,M.SATTLER,D.GORLICHTITL NES CONSENSUS REDEFINED BY STRUCTURES OF PKI-TYPE ANDTITL 2 REV-TYPE NUCLEAR EXPORT SIGNALS BOUND TO CRM1.REF NAT.STRUCT.MOL.BIOL. V. 17 1367 2010REFN ISSN 1545-9993PMID 20972448DOI 10.1038/NSMB.1931 Variant Set Distributions Mapped Variants