Assessment of Structural Intolerance and Durability
General Structure Information 2d9n CPSF4 solution structure of ccch type zinc-finger domain 2 in cleavage and polyadenylation specificity factor -1.0Å AUTH C.ABE,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,M.SHIROUZU,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF CCCH TYPE ZINC-FINGER DOMAINTITL 2 2 IN CLEAVAGE AND POLYADENYLATION SPECIFICITYTITL 3 FACTORREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 6rlx RLN2 x-ray structure of human relaxin at 1.5 angstroms. comparison to insulin and implications for receptor binding determinants 1.5Å AUTH C.EIGENBROT,M.RANDAL,C.QUAN,J.BURNIER,L.OCONNELL,AUTH 2 E.RINDERKNECHT,A.A.KOSSIAKOFFTITL X-RAY STRUCTURE OF HUMAN RELAXIN AT 1.5 A. COMPARISON TOTITL 2 INSULIN AND IMPLICATIONS FOR RECEPTOR BINDING DETERMINANTS.REF J.MOL.BIOL. V. 221 15 1991REFN ISSN 0022-2836PMID 1656049 Variant Set […]
General Structure Information 1lq8 SERPINA5 crystal structure of cleaved protein c inhibitor 2.4Å AUTH J.A.HUNTINGTON,M.KJELLBERG,J.STENFLOTITL CRYSTAL STRUCTURE OF PROTEIN C INHIBITOR PROVIDES INSIGHTSTITL 2 INTO HORMONE BINDING AND HEPARIN ACTIVATIONREF STRUCTURE V. 11 205 2003REFN ISSN 0969-2126PMID 12575940DOI 10.1016/S0969-2126(02)00944-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1lq8 SERPINA5 crystal structure of cleaved protein c inhibitor 2.4Å AUTH J.A.HUNTINGTON,M.KJELLBERG,J.STENFLOTITL CRYSTAL STRUCTURE OF PROTEIN C INHIBITOR PROVIDES INSIGHTSTITL 2 INTO HORMONE BINDING AND HEPARIN ACTIVATIONREF STRUCTURE V. 11 205 2003REFN ISSN 0969-2126PMID 12575940DOI 10.1016/S0969-2126(02)00944-9 Variant Set Distributions Mapped Variants
General Structure Information 2uzp PRKCG crystal structure of the c2 domain of human protein kinase c gamma. 2.0Å AUTH A.C.W.PIKE,A.AMOS,C.JOHANSSON,F.SOBOTT,P.SAVITSKY,AUTH 2 G.BERRIDGE,O.FEDOROV,C.UMEANO,F.GORREC,G.BUNKOCZI,AUTH 3 J.DEBRECZENI,F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,J.WEIGELT,AUTH 4 M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF C2 DOMAIN OF PROTEIN KINASE C GAMMAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4f0x MLYCD crystal structure of human malonyl-coa decarboxylase (peroxisomal isoform) 3.29Å AUTH D.APARICIO,R.PEREZ-LUQUE,X.CARPENA,M.DIAZ,J.C.FERRER,AUTH 2 P.C.LOEWEN,I.FITATITL STRUCTURAL ASYMMETRY AND DISULFIDE BRIDGES AMONG SUBUNITSTITL 2 MODULATE THE ACTIVITY OF HUMAN MALONYL-COA DECARBOXYLASE.REF J.BIOL.CHEM. V. 288 11907 2013REFN ISSN 0021-9258PMID 23482565DOI 10.1074/JBC.M112.443846 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3se4 IFNW1 human ifnw-ifnar ternary complex 3.5Å AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 Variant Set Distributions Mapped Variants
General Structure Information 1tpg PLAT f1-g module pair residues 1-91 (c83s) of tissue-type plasminogen activator (t-pa) (nmr, 298k, ph2.95, representative structure) -1.0Å AUTH B.O.SMITH,A.K.DOWNING,P.C.DRISCOLL,T.J.DUDGEON,AUTH 2 I.D.CAMPBELLTITL THE SOLUTION STRUCTURE AND BACKBONE DYNAMICS OFTITL 2 THE FIBRONECTIN TYPE I AND EPIDERMAL GROWTHTITL 3 FACTOR-LIKE PAIR OF MODULES OF TISSUE-TYPETITL 4 PLASMINOGEN ACTIVATOR.REF STRUCTURE V. 3 823 […]
General Structure Information 3rsw FABP3 crystal structure of heart fatty acid binding protein (fabp3) 2.6Å AUTH D.F.CARNEY,B.SHANKARAN,P.H.ZWART,J.W.STEBBINS,G.S.PRASADTITL CRYSTAL STRUCTURE OF HEART FATTY ACID BINDING PROTEINTITL 2 (FABP3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ruk CYP17A1 human cytochrome p450 cyp17a1 in complex with abiraterone 2.6Å AUTH N.M.DEVORE,E.E.SCOTTTITL STRUCTURES OF CYTOCHROME P450 17A1 WITH PROSTATE CANCERTITL 2 DRUGS ABIRATERONE AND TOK-001.REF NATURE V. 482 116 2012REFN ISSN 0028-0836PMID 22266943DOI 10.1038/NATURE10743 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants